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| 1 | 肿瘤出芽和PDC分级是错配修复缺陷的结直肠癌临床转归分期的独立预测因子显示文摘错配修复缺陷(dMMR)的结直肠癌(CRC)在临床、病理及分子特征方面与无错配修复缺陷(pMMR)的CRC存在区别,其好发于右半结肠,具有低分化、多黏液成分、大量肿瘤细胞浸润淋巴组织及克罗恩样的宿主反应等特征。已有研究显示dMMR CRC预后比pMMR CRC好。dMMR CRC很少发生淋巴结转移(LNM)及同期肝脏转移。dMMR CRC虽具有高级别肿瘤特征,却有较好的预后,对这种违背常理的情况,有学者提出传统的WHO分级可能无法明确判断其预后。 | Ryan E Khaw Y L Creavin B 黄爱清 余英豪 | 2018 | 临床与实验病理学杂志2018，34，9： | 14 |
| 2 | The impact of minimally invasive surgeries for the treatment of symptomatic benign prostatic hyperplasia on male sexual function: a systematic review显示文摘使随机化的控制试用和队研究的系统的评论被进行在男性功能上为征兆的良性的 prostatic 增生(BPH ) 的处理为最低限度地侵略的过程的效果评估数据。寻找的研究是与征兆的 BPH 注册了人的试用与激光手术,经尿道的微波治疗( TUMT ),前列腺(金枪鱼)的经尿道的针脱离,前列腺( TEAP )的经尿道的乙醇脱离和高紧张的频率超声( HIFU )被对待,与前列腺( TURP )或假冒的操作的传统的经尿道的切除术比较。72 研究的一个总数被识别,哪个 33 满足了包括标准。33 研究, 21 涉及了激光手术,六与 TUMT,四与金枪鱼并且二与包含信息考虑的 TEAP 男性功能。没有学习关于为男性功能上的 BPH 的 HIFU 的效果是可得到的。我们的分析证明为 BPH 的最低限度地侵略的手术在男可勃起的功能上 TURP 有可比较的效果到那些。一起,分别地,不到 15.4% 病人或 15.2% 将在激光过程, TUMT 和金枪鱼以后可勃起的功能有减少或增加。是与 TURP 观察了,射精的机能障碍(EjD ) 的高发生在有钬, potassium-titanyl-phosphate 和铥激光治疗的 BPH 的治疗以后是普通的(>33.6%) 。TUMT,金枪鱼和 neodymium:yttrium 铝石榴石为 BPH 的视觉激光脱离或空隙的激光凝结有更少的发生 EjD,而是这些过程为 BPH 治疗被认为更少有效什么时候与 TURP 相比。 | Ryan W. Frieben Hao-Cheng Lin Peter E Hinh Francesco Berardinelli Steven E. Canfield Run Wang | 2010 | Asian Journal of Andrology2010，12，4： | 13 |
| 3 | Nat Chem Biol:利用CRISPR-Cas9激活细菌中沉默的基因簇,有望发现新的药物显示文摘为了抵抗疾病,很多医药库中的武器是从细菌当中获得的。如今,利用CRISPR-Cas9基因编辑技术。研究人员揭示出沉默基因中隐藏着的更多潜在的宝藏。作为一类常见的细菌。链霉菌被用来产生很多作为抗生素、抗癌试剂和其他药物的化合物。在一项新的研究中。来自美国伊利诺伊大学和新加坡科技研究局的研究人员利用CRISPR-Cas9技术激活链霉菌中不表达的或者说沉默的基因簇。 | Mingzi M Zhang, Wan Lin Yeo, Ee Lui Ang, Huimin Zhao Fong Tian Wong, Elena Heng Yajie Wang, Shangwen Luo, Ryan E Cobb, Behnam Enghiad, Huimin Zhao Yee Hwee Lim | 2017 | 现代生物医学进展2017，17，17： | 12 |
| 4 | Augmented reality assisted surgery: a urologic training tool显示文摘扩充现实广泛地在航空学被使用并且是在外科以内的一个发展中的概念。在这个预研项目,我们在古格尔·格拉斯 ® 上为使用开发了一个应用程序训练在怎么放可膨胀的阴茎修复术的泌尿学居民的光装头的显示。我们使用扩充的短语现实帮助了外科在外科的设置描述扩充现实的这个新奇应用程序。应用程序表明可膨胀的阴茎修复术放置的外科的过程的步。它也包含允许的软件用一个照相机的点从光装头的显示喂使教师能在阴茎修复术的放置期间与居民一起交往的兴趣的察觉。自愿参加学习的泌尿学受训练者和教师被给时间经历技术在起作用或 perioperative 背景并且要求完成反馈调查。从用 10 点规模的 30 个全部的参加者,教育实用性被评估 8.6,航行的容易被评估 7.6,到使用的可能性的被评估 7.4,并且在操作空间的分心被评估 4.9。当在受训练者和教师之间成层时,受训练者发现技术更教育有用,并且少些分散。总的来说, 81% 参加者在他们的住处程序想要这种技术,并且 93% 以后在操作房间里看见这种技术。这种技术的进一步的开发在完整的版本前被保证,并且进一步的研究是必要的更好描绘扩充现实的有效性在泌尿科的外科的训练的帮助外科。 | Ryan M Dickey Neel Srikishen Larry I Lipshultz Philippe E Spiess Rafael E Carrion Tariq S Hakky | 2016 | Asian Journal of Andrology2016，18，5： | 6 |
| 5 | The hypoxia-inducible factor-1α activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia显示文摘Tumor-induced osteomalacia(TIO) is a rare paraneoplastic syndrome in which ectopic production of fibroblast growth factor 23(FGF23) by non-malignant mesenchymal tumors causes phosphate wasting and bone fractures. Recent studies have implicated the hypoxia-inducible factor-1α(HIF-1α) in other phosphate wasting disorders caused by elevated FGF23, including X-linked hypophosphatemic rickets and autosomal dominant hypophosphatemia. Here we provide evidence that HIF-1α mediates aberrant FGF23 in TIO by transcriptionally activating its promoter. Immunohistochemical studies in phosphaturic mesenchymal tumors resected from patients with documented TIO showed that HIF-1α and FGF23 were co-localized in spindleshaped cells adjacent to blood vessels. Cultured tumor tissue produced high levels of intact FGF23 and demonstrated increased expression of HIF-1α protein. Transfection of MC3T3-E1 and Saos-2 cells with a HIF-1α expression construct induced the activity of a FGF23 reporter construct. Prior treatment of tumor organ cultures with HIF-1α inhibitors decreased HIF-1α and FGF23 protein accumulation and inhibited HIF-1α-induced luciferase reporter activity in transfected cells. Chromatin immunoprecipitation assays confirmed binding to a HIF-1α consensus sequence within the proximal FGF23 promoter, which was eliminated by treatment with a HIF-1α inhibitor. These results show for the first time that HIF-1α is a direct transcriptional activator of FGF23 and suggest that upregulation of HIF-1α activity in TIO contributes to the aberrant FGF23 production in these patients. | Qian Zhang Michele Doucet Ryan E Tomlinson Xiaobin Han L Darryl Quarles Michael T Collins Thomas L Clemens | 2016 | Bone Research2016，4，2： | 6 |
| 6 | Hzf and hCAS/CSEIL: making the right choice in p53-mediated tumour suppression显示文摘 | Katherine E Ewings Kevin M Ryan | 2007 | Cell Research2007，17，10： | 2 |
| 7 | Antagonism of miR-33 in mice promotes reverse cholesterol transport and regression of atherosclerosis显示文摘 | Rayner Katey J Sheedy Frederick J Esau Christine C Hussain Farah N Temel Ryan E Parathath Saj van Gils Janine M Rayner Alistair J Chang Aaron N Suarez Yajaira Fernandez-Hernando Carlos Fisher Edward A Moore Kathryn J | 2011 | Journal of Clinical Investigation2011，，7： | 2 |
| 8 | HIF-1α is required for solid tumor formation and embryonic vascularization显示文摘 | Ryan H E Lo J Johnson R S | 1998 | EMBO J1998，17，11： | 2 |
| 9 | Hypoxia in cartilage: HIF-1αis essential for chondrocyte growth arrest and survival显示文摘 | Schipani E Ryan H E Didrickson S | 2001 | Genes Develop2001，15，21： | 2 |
| 10 | A new framework for reverse cholesterol transport: Non-biliary contributions to reverse cholesterol transport显示文摘Reduction of low-density lipoprotein-cholesterol through statin therapy has only modestly decreased coronary heart disease (CHD)-associated mortality in developed countries, which has prompted the search for alternative therapeutic strategies for CHD. Major efforts are now focused on therapies that augment high-density lipoprotein (HDL)-mediated reverse cholesterol transport (RCT), and ultimately increase the fecal disposal of cholesterol. The process of RCT has long been thought to simply involve HDL-mediated delivery of peripheral cholesterol to the liver for biliary excretion out of the body. However, recent studies have revealed a novel pathway for RCT that does not rely on biliary secretion. This nonbiliary pathway rather involves the direct excretion of cholesterol by the proximal small intestine. Compared to RCT therapies that augment biliary sterol loss, modulation of non-biliary fecal sterol loss through the intestine is a much more attractive therapeutic strategy, given that excessive biliary cholesterol secretion can promote gallstone formation. However, we are at an early stage in understanding the molecular mechanisms regulating the non-biliary pathway for RCT, and much additional work is required in order to effectively target this pathway for CHD prevention. The purpose of this review is to discuss our current understanding of biliary and nonbiliary contributions to RCT with particular emphasis on the possibility of targeting the intestine as an inducible cholesterol secretory organ. | Ryan E Temel J Mark Brown | 2010 | World Journal of Gastroenterology2010，16，47： | 2 |
| 11 | The elemental composition of street dust from large and small urban areas related to city type,source and particle size显示文摘 | Fergusson J E Ryan D E | 1984 | Science of the Total Environment1984，34，： | 2 |
| 12 | Hypoxia-inducible factor-1 alpha is essential for cell cycle arrest during hypoxia 显示文摘 | Goda N Ryan H E Khadivi B | 2003 | Mol Cell Biol2003，23，1： | 1 |
| 13 | Low-gain integral control of continuous-time linear systems subject to input and output nonlinearities显示文摘 | FLIEGNER T LOGEMANN H RYAN E P | 2003 | Automatica2003，39，： | 1 |
| 14 | The inhibi- tion of aluminum alloy corrosion by cerium cations 显示文摘 | Hinton B R W Arnott D R Ryan N E | 1984 | Metals Forum1984，7，： | 1 |
| 15 | Cerium conversion coatings for the corrosion protection of aluminum 显示文摘 | Hinton B R W Aruott D R Ryan N E | 1986 | Materials Forum1986，9，3： | 1 |
| 16 | Regulation of expression of proteinase inhibitor genes by methyl jasmonate and jasmonic acid 显示文摘 | FARMER E E JOHNSON R R RYAN C A | 1992 | Plant Physio11992，98，： | 1 |
| 17 | Isolation,characterization andcom-parison of human endometrial and endometriosis cells in vitro 显示文摘 | Ryan IP Schriock E Taylor RN | 1994 | JClin Endocrinol Metab1994，78，3： | 1 |
| 18 | Self-determination theory and the facilitation of intrinsic motivation, social develop- ment, and well-being 显示文摘 | Ryan R M Deci E L | 2000 | American Psychologist2000，55，1： | 1 |
| 19 | The growth of silicon carbide needles by the vapor-liquid- solid method 显示文摘 | Berman Ryan C E | 1971 | Journal of Crystal Growth1971，9，： | 1 |
| 20 | Regulating of expression of proteinase inhibitor genes by methyl jasmonate and jasmonic acid 显示文摘 | Farmer E E Johnson R R Ryan C A | 1992 | Plant Physiol1992，98，： | 1 |
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