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| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | Electron beam lithography-resolution limits显示文摘 | Broers A N Hoole A C F Ryan J M | 1996 | Microelectronic Engineering1996，32，： | 1 |
| 3 | Inhibitory effects of nordihydroguaiaretic acid (NDGA) on the IGF-1 receptor and androgen dependent growth of LAPC-4 prostate cancer cells 显示文摘 | Ryan C J Zavodovskaya M Youngren J F | 2008 | Prostate2008，68，11： | 1 |
| 4 | Oligosaccharide signals in plants: A current assessment 显示文摘 | Ryan C A Farmer E F | 1991 | Annu Rev Phy-Siol Mol Biol1991，42，651： | 1 |
| 5 | The Siberian Lithosphere Traverse: Mantle Terranes and the Assembly of the Siberian Craton显示文摘 | GRIFFIN W L RYAN C G KAMINSKY F V | 1999 | Tectono- physics1999，310，1234： | 1 |
| 6 | Evaluating MBA- Program Admissions Criteria: The Relationship Between Pre-MBA Work Experience and Post-MBA Career Outcomes显示文摘 | George F Dreher and Katherine C Ryan | 2003 | Research in Higher Education2003，，06： | 1 |
| 7 | Mechanical properties of the velopharynx in obese patients with obstructive sleep apnea显示文摘 | Ryan C F Love L L | | 0，，3： | 1 |
| 8 | Temperature prediction in stratified reservoirs 显示文摘 | Huber W C Harleman D R F Ryan P J | 1972 | Journal of the Hydraulics Division1972，98，4： | 1 |
| 9 | Evaluating Policies and Mechanisms to Support Distributed Real-Time Applications with CORBA显示文摘 | C O'Ryan D C Schmidt F Kuhns | 2001 | Concurrency and Computing:Practice and Experience2001，13，2： | 1 |
| 10 | GDNF protects the cochlea against noise damage显示文摘 | Keithley E M Ma C L Ryan A F | 1998 | Neuroreport1998，13，： | 1 |
| 11 | Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning显示文摘 | Samuel Davis Thomas H Aldrich Pamela F Jones Ann Acheson Debra L Compton Vivek Jain Terence E Ryan Joanne Bruno Czeslaw Radziejewski Peter C Maisonpierre George D Yancopoulos | 1996 | Cell1996，，7： | 1 |
| 12 | Aspergillus-related lung disease显示文摘 | A1-Alawi A Ryan C F Flint J D Mailer N L | 2005 | Can Respir J2005，12，： | 1 |
| 13 | Sedimentary features associated with channel overbank flow: Examples from the Monterey Fan 显示文摘 | McHugh C M G Ryan W B F | 2000 | Marine Geology2000，163，： | 1 |
| 14 | Thermal State and Composition of the Lithospheric Mantle Beneath the Daldyn Kimberlite Field, Yakutia 显示文摘 | GRIFFIN W L KAMINSKY F V RYAN C G | 1996 | Tectonophysies1996，262，1234： | 1 |
| 15 | Effects of COX inhibitors on neurodegeneration and survival in mice exposed to the marine neurotoxin domoic acid显示文摘 | Ryan J C Cross C A Van Dolah F M | | 0，，01： | 1 |
| 16 | Sedimentary features associated with channel overbank flow:examples from the Monterey Fan显示文摘 | MCHUGH C M G RYAN W B F | 2000 | Mar Geol2000，163，： | 1 |
| 17 | Programming infant gut microbiota: influence of dietary and environmental factors显示文摘 | Tatiana Milena Marques Rebecca Wall R Paul Ross Gerald F Fitzgerald C Anthony Ryan Catherine Stanton | 2010 | Current Opinion in Biotechnology2010，，2： | 1 |
| 18 | The effects of increasedmilking frequency during early lactation on milk yield and milk compositionon commercial dairy farms显示文摘 | Soberon F Ryan C M Nydam D V | 2011 | Dairy Sci2011，94，9： | 1 |
| 19 | Electron beam lithography-resolution limits显示文摘 | BROERS A N HOOLE A C F RYAN J M | 1996 | Mieroelectronic Engineering1996，32，14： | 1 |
| 20 | Prevalence of osteonecrosis of the jaw in patients with oral bisphosphonate exposure显示文摘 | LO J C G'RYAN F S GORDON N P | 2010 | J Oral Maxillofac Surg2010，68，2： | 1 |
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