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| 1 | Saliva: potential diagnostic value and transmission of 2019-nCoV显示文摘2019-n Co V epidemic was firstly reported at late December of 2019 and has caused a global outbreak of COVID-19 now.Saliva,a biofluid largely generated from salivary glands in oral cavity,has been reported 2019-n Co V nucleic acid positive.Besides lungs,salivary glands and tongue are possibly another hosts of 2019-n Co V due to expression of ACE2.Close contact or short-range transmission of infectious saliva droplets is a primary mode for 2019-n Co V to disseminate as claimed by WHO,while long-distance saliva aerosol transmission is highly environment dependent within indoor space with aerosol-generating procedures such as dental practice.So far,no direct evidence has been found that 2019-n Co V is vital in air flow for long time.Therefore,to prevent formation of infectious saliva droplets,to thoroughly disinfect indoor air and to block acquisition of saliva droplets could slow down2019-n Co V dissemination.This review summarizes diagnostic value of saliva for 2019-n Co V,possibly direct invasion into oral tissues,and close contact transmission of 2019-n Co V by saliva droplets,expecting to contribute to 2019-n Co V epidemic control. | Ruoshi Xu Bomiao Cui Xiaobo Duan Ping Zhang Xuedong Zhou Quan Yuan | 2020 | International Journal of Oral Science2020，12，2： | 9 |
| 2 | Ratiometric delivery of doxorubicin and berberine by liposome enables superior therapeutic index than Doxil?显示文摘Although the appearance of Doxil alleviated the cardiotoxicity of DOX, the progression-free survival of patients was not prolonged compared with traditional medication regimens, and side effects such as hand-foot syndrome has occurred. In order to solve this dilemma, we have designed a novel co-delivery strategy to construct a co-loaded liposome of berberine(BER) and doxorubicin(DOX), which was called Lipo Be Do. The optimal synergistic ratio of the two drugs was screened by cell cytotoxicity experiments in vitro, and the optimal attenuation ratio was further determined by in vivo cardiac H&E staining pathological sections. The optimal combination treatment caused a robust increase in apoptotic cells of 4T1, as compared to drug alone treatment. The prepared co-loaded liposome, Lipo Be Do, had high encapsulation efficiency and good stability. The nanoliposome carrier controlled the biological fate of the drugs and maintained a pre-defined optimal ratio in vivo. The Lipo Be Do significantly inhibited tumor growth in 4T1 murine mammary carcinoma model compared with Doxil(P < 0.05), and completely overcame the myocardial rupture toxicity caused by Doxil in mice. Our co-loaded liposome delivery platform technology provided a new direction for the clinical treatment of triple-negative breast cancer and the safe application of DOX. | Ruoshi Zhang Yingxi Zhang Yue Zhang Xin Wang Xuanming Gao Yuyan Liu Xuanbo Zhang Zhonggui He Dun Wang Yongjun Wang | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，3： | 4 |
| 3 | AFF4 regulates osteogenic differentiation of human dental follicle cells显示文摘As a member of the AFF(AF4/FMR2)family,AFF4 is a transcription elongation factor that is a component of the super elongation complex.AFF4 serves as a scaffolding protein that connects transcription factors and promotes gene transcription through elongation and chromatin remodelling.Here,we investigated the effect of AFF4 on human dental follicle cells(DFCs)in osteogenic differentiation.In this study,we found that small interfering RNA-mediated depletion of AFF4 resulted in decreased alkaline phosphatase(ALP)activity and impaired mineralization.In addition,the expression of osteogenic-related genes(DLX5,SP7,RUNX2 and BGLAP)was significantly downregulated.In contrast,lentivirus-mediated overexpression of AFF4 significantly enhanced the osteogenic potential of human DFCs.Mechanistically,we found that both the mRNA and protein levels of ALKBH1,a critical regulator of epigenetics,changed in accordance with AFF4 expression levels.Overexpression of ALKBH1 in AFF4-depleted DFCs partially rescued the impairment of osteogenic differentiation.Our data indicated that AFF4 promoted the osteogenic differentiation of DFCs by upregulating the transcription of ALKBH1. | Qingyue Xiao Yuning Zhang Xingying Qi Yaqian Chen Rui Sheng Ruoshi Xu Quan Yuan Chenchen Zhou | 2020 | International Journal of Oral Science2020，12，4： | 4 |
| 4 | Ecosystem health towards sustainability显示文摘Ecosystems are becoming damaged or degraded as a result of stresses especially associated with human activities.A healthy ecosystem is essential to provide the services that humans and the natural environment require and has tremendous social and economic value.Exploration of the definition of ecosystem health includes what constitutes health and what it means to be healthy.To evaluate ecosystem health,it is necessary to quantify ecosystem conditions using a variety of indicators.In this paper,the main principles and criteria for indicator selection,classification of indicators for different kinds of ecosystems,the most appropriate indicators for measuring ecosystem sustainability,and various methods and models for the assessment of ecosystem health are presented.Drivers,sustainability,and resilience are considered to be critical factors for ecosystem health and its assessment.Effective integration of ecological understanding with socioeconomic,biophysical,biogeochemical,and public-policy dimensions is still the primary challenge in this field,and devising workable strategies to achieve and maintain ecosystem health is a key future challenge. | Yonglong Lu Ruoshi Wang Yueqing Zhang Hongqiao Su Pei Wang Alan Jenkins Rober C.Ferrier Mark Bailey Geoff Squire | 2015 | Ecosystem Health and Sustainability2015，1，1： | 3 |
| 5 | Genomic and transcriptomic analysis unveils population evolution and development of pesticide resistance in fall armyworm Spodoptera frugiperda显示文摘The fall armyworm(FAW),Spodoptera frugiperda,is a destructive pest native to America and has recently become an invasive insect pest in China.Because of its rapid spread and great risks in China,understanding of FAW genetic background and pesticide resistance is urgent and essential to develop effective management strategies.Here,we assembled a chromosome-level genome of a male FAW(SFynMstLFR)and compared re-sequencing results of the populations from America,Africa,and China.Strain identification of 163 individuals collected from America,Africa and China showed that both C and R strains were found in the American pop-ulations,while only C strain was found in the Chinese and African populations.Moreover,population geno-mics analysis showed that populations from Africa and China have close relationship with significantly genetic differentiation from American populations.Taken toge-ther,FAWs invaded into China were most likely origi-nated from Africa.Comparative genomics analysis displayed that the cytochrome p450 gene family is extremely expanded to 425 members in FAW,of which 283 genes are specific to FAW.Treatments of Chinese populations with twenty-three pesticides showed the variant patterns of transcriptome profiles,and several detoxification genes such as AOX,UGT and GST spe-cially responded to the pesticides.These findings will be useful in developing effective strategies for manage-ment of FAW in China and other invaded areas. | Furong Gui Tianming Lan Yue Zhao Wei Guo Yang Dong Dongming Fang Huan Liu Haimeng Li Hongli Wang Ruoshi Hao Xiaofang Cheng Yahong Li Pengcheng Yang Sunil Kumar Sahu Yaping Chen Le Cheng Shuqi He Ping Liu Guangyi Fan Haorong Lu Guohai Hu Wei Dong Bin Chen Yuan Jiang Yongwei Zhang Hanhong Xu Fei Lin Bernard Slippers Alisa Postma Matthew Jackson Birhan Addisie Abate Kassahun Tesfaye Aschalew Lemma Demie Meseret Destaw Bayeleygne Dawit Tesfaye Degefu Feng Chen Paul K.Kuria Zachary M.Kinyua Tong-Xian Liu Huanming Yang Fangneng Huang Xin Liu Jun Sheng Le Kang | 2022 | Protein & Cell2022，13，7： | 2 |
| 6 | METTL3-mediated m^(6)A RNA methylation regulates dorsal lingual epithelium homeostasis显示文摘The dorsal lingual epithelium,which is composed of taste buds and keratinocytes differentiated from K14^(+)basal cells,discriminates taste compounds and maintains the epithelial barrier.N6-methyladenosine(m^(6)A)is the most abundant mRNA modification in eukaryotic cells.How METTL3-mediated m^(6)A modification regulates K14^(+)basal cell fate during dorsal lingual epithelium formation and regeneration remains unclear.Here we show knockout of Mettl3 in K14^(+)cells reduced the taste buds and enhanced keratinocytes.Deletion of Mettl3 led to increased basal cell proliferation and decreased cell division in taste buds.Conditional Mettl3 knock-in mice showed little impact on taste buds or keratinization,but displayed increased proliferation of cells around taste buds in a protective manner during post-irradiation recovery.Mechanically,we revealed that the most frequent m^(6)A modifications were enriched in Hippo and Wnt signaling,and specific peaks were observed near the stop codons of Lats1 and FZD7.Our study elucidates that METTL3 is essential for taste bud formation and could promote the quantity recovery of taste bud after radiation. | Qiuchan Xiong Caojie Liu Xin Zheng Xinyi Zhou Kexin Lei Xiaohan Zhang Qian Wang Weimin Lin Ruizhan Tong Ruoshi Xu Quan Yuan | 2022 | International Journal of Oral Science2022，14，3： | 2 |
| 7 | Association of Sandstone-Type Uranium Mineralization in the Northern China with Tectonic Movements and Hydrocarbons显示文摘In the continental basins of Northern China(NC),a series of energy resources commonly co-exist in the same basin.As the three typical superimposed basins of different genesis in the NC,the Junggar,Ordos,and Songliao basins were chosen as the research objects.The favorable uraniumbearing structures are generally shown as a basin-margin slope or transition belt of uplifts with the development of faults,which are conducive to a fluid circulation system.The Hercynian,Indosinian,and Yanshanian movements resulted in the development of uranium-rich intrusions which acted as the significant uranium sources.The main hydrocarbon source rocks are developed in the Carboniferous,Permian,Jurassic and Cretaceous.The mature stage of source rocks is concentrated in the Jurassic–Cretaceous,followed by the multi-stage expulsion events.Influenced by the India-Eurasian collision and the subduction of the Pacific Plate,the tectonic transformation in the Late Yanshanian and Himalayan periods significantly influenced the sandstone-type uranium mineralization.The hydrocarbon reservoirs are spatially consistent with sandstone-type uranium deposits,while the hydrocarbon expulsion events occur in sequence with sandstone-type uranium mineralization.In the periphery of the faults or the uplifts,both fluids met and formed uranium concentration.The regional tectonic movements motivate the migration of hydrocarbon fluids and uranium mineralization,especially the Himalayan movement. | Yin Chen Peisen Miao Jianguo Li Ruoshi Jin Hualei Zhao Lulu Chen CongWang HaoyuYu Xiaoru Zhang | 2022 | Journal of Earth Science2022，33，2： | 2 |
| 8 | Characteristics of natural biopolymers and their derivative as sorbents for chromium adsorption:a review显示文摘Chromium is widely used in industry,and improper disposal of wastewater and industrial residues containing excessive chromium can contaminate water and soil,endangering both environmental and human health.Natural biopolymers and their derivatives have been investigated for removal of chromium(Cr)from wastewater.Cellulose,lignin,tannin,chitin,chitosan,and polypeptides are abundant in nature,and have high potential as adsorbents due to their easy access,low cost,and the recyclability of the captured heavy metals.In order to improve their mechanical strength,recyclability,specific surface area,binding site number,and adsorption rate as adsorbents,native materials have also been modified.This review discusses the source of chromium contamination and the main species of interest,as well as their toxicity.The structures of the aforementioned biopolymers were analyzed,and the adsorption mechanism of chromium and the main influencing factors on this process are discussed.The modification methods of various adsorbents and their adsorption effects on chromium are also detailed,and the developmental direction of research on the use of biopolymer adsorption remediation to control chromium contamination is discussed. | Ruoshi Zhang Yongqiang Tian | 2020 | Journal of Leather Science and Engineering2020，2，1： | 1 |
| 9 | Application of nano-patterned InGaN fabricated by selfassembled Ni nano-masks in green InGaN/GaN multiple quantum wells显示文摘The nano-patterned InGaN film was used in green InGaN/GaN multiple quantum wells(MQWs)structure,to relieve the unpleasantly existing mismatch between high indium content InGaN and GaN,as well as to enhance the light output.The different self-assembled nano-masks were formed on InGaN by annealing thin Ni layers of different thicknesses.Whereafter,the InGaN films were etched into nano-patterned films.Compared with the green MQWs structure grown on untreated InGaN film,which on nano-patterned InGaN had better luminous performance.Among them the MQWs performed best when 3 nm thick Ni film was used as mask,because that optimally balanced the effects of nano-patterned InGaN on the crystal quality and the light output. | Ruoshi Peng Shengrui Xu Xiaomeng Fan Hongchang Tao Huake Su Yuan Gao Jincheng Zhang Yue Hao | 2023 | Journal of Semiconductors2023，44，4： | 0 |
| 10 | Rumor recognition behavior of social media users in emergencies显示文摘Social media rumors not only affect the health of online social networks,but also reduce the quality of information accessed by its users.In the case of emergencies,the rapid spread of rumors often triggers mass anxiety and panic.This study integrates the planned behavior(TPB)and deterrence(TD)theories to study the factors affecting the rumor recognition behavior of social media users.The structural equation model(SEM)method is used to test the proposed model.Further,the interaction between various factors is analyzed to evaluate their impact on the rumor recognition behavior exhibited by social media users in emergencies.The results demonstrate that certainty and severity have significant positive effects on subjective norms.In addition,subjective norms,attitude,and perceived behavioral control all affect the rumor recognition behavior of social media users,and involvement negatively moderates the relationship between the subjective norms and attitude.Finally,insights into the formulation of rumor control strategies during emergencies are presented based on the empirical analysis. | Xuejun Ding Xiaxia Zhang Ruoshi Fan Qiaochu Xu Kyle Hunt Jun Zhuang | 2022 | Journal of Management Science and Engineering2022，7，1： | 0 |
| 11 | Enhancement of optical characteristic of InGaN/GaN multiple quantum-well structures by self-growing air voids显示文摘InGaN/GaN multiple quantum-well(MQW) structures with a wavelength range of green were successfully grown on a c-plane GaN template with SiO_2 stripe patterns along the [11-20] and [1-100] directions as a mask. The surface morphologies of both samples were investigated using scanning electron microscopy and demonstrated anisotropic growth characteristics of GaN. The optical characteristics were investigated using Raman spectra and photoluminescence(PL). The InGaN/GaN MQW structure grown on the GaN template with SiO_2 stripes along the [1-100] orientation exhibited less stress and higher PL intensity.Transmission electron microscopy results indicated that portions of MQWs were grown on an inclined semipolar plane, and air voids occurred only when the direction of the mask stripe was along the [1-100] orientation. The enhancement of the optical characteristic was due to the air-void structure and inclined semipolar quantum-well sidewalls. | DU JinJuan XU ShengRui PENG RuoShi FAN XiaoMeng ZHAO Ying TAO HongChang SU HuaKe NIU MuTong ZHANG JinCheng HAO Yue | 2021 | Science China(Technological Sciences)2021，64，7： | 0 |
| 12 | Integrating ergonomics data and emotional scale to analyze people’s emotional attachment to different landscape features in the Wudaokou Urban Park显示文摘Against the background of urban renewal,the landscape transformation of urban public space into urban parks has become an effective way of improving environmental quality and creating an emotional attachment for people.Meanwhile,existing studies have seldom adopted experimental methods to scientifically reveal the effect of different landscape features on emotional experience.Using a portable eye movement tracker,wearable wireless physiological sensor,and emotional attachment scale,this study collects participants’ergonomics data,and their degree and dimension of emotional attachment while experiencing different landscape features in Wudaokou Park in Beijing,China.The data were analyzed with the help of ErgoLab platform and IBM SPSS software.The results indicate that the artificial and natural landscape features and their specific characteristics have different effects on eye movement index,heart rate variability,skin conductance level,and attachment degree and dimension.The design of Wudaokou Park was proven to significantly promote emotional attachment.Natural features play an important role,among which the use of wild plants and gazebosdshowing the texture and structural logic of bamboo materialsdstand out.The research not only expands the practical scope of ergonomics instruments and improves the rationality of the emotional attachment scale,but also provides emotion-oriented design methods for urban researchers and designers to improve the emotional experience in urban parks in the future. | Ruoshi Zhang | 2023 | Frontiers of Architectural Research2023，12，1： | 0 |
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