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| 1 | Rapid and sensitive liquid chromatography–tandem mass spectrometric method for the quantitative determination of potentially harmful substance 5,5′-oxydimethylenebis (2-furfural) in traditional Chinese medicine injections显示文摘With the rapid development and wide application of traditional Chinese medicine injection(TCMI), a number of adverse events of some TCMIs have incessantly been reported and have drawn broad attention in recent years. Establishing effective and practical analytical methods for safety evaluation and quality control of TCMI can help to improve the safety of TCMIs in clinical applications. In this study, a sensitive and rapid high-performance liquid chromatography–tandem mass spectrometry(HPLC–MS/MS)method has been developed and validated for the quantitative determination of potentially harmful substance5,5′-oxydimethylenebis(2-furfural, OMBF) in TCMI samples. Chromatographic separation was performed on a C18 reversed-phase column(150 mm × 2.1 mm, 5 μm) by gradient elution, using methanol–water containing 0.1% formic acid as mobile phase at the flow rate of 0.3 m L/min. MS/MS detection was performed on a triple quadrupole mass spectrometer with positive electrospray ionization in the multiple reaction-monitoring mode. The method was sensitive with a limit of quantification of 0.3 ng/m L and linear over the range of 0.3–30 ng/m L(r = 0.9998). Intra-and inter-day precision for analyte was o9.52% RSD withrecoveries in the range 88.0–109.67% at three concentration levels. The validated method was successfully applied to quantitatively determine the compound OMBF in TCMIs and glucose injections. Our study indicates that this method is simple, sensitive, practicable and reliable, and could be applied for safety evaluation and quality control of TCMIs and glucose injections. | Qingce Zang Yang Gao Luojiao Huang Jiuming He Sheng Lin Hongtao Jin Ruiping Zhang Zeper Abliz | 2018 | Acta Pharmaceutica Sinica B2018，8，2： | 4 |
| 2 | Elastic Scattering of 7Be on Pb Target显示文摘 | Yang Yanyun Wang Jiansong Wang Qi Huang Meirong Ma Junbing Ma Peng Cao Xiguang Han Jianlong Bai Zhen Jin Shilong Hu Qiang Jin Lei Chen Jiangbo Zhang Xueying Chen Ruofu Hu Zhengguo Xu Shiwei Zhen Chuan Xu Zhiguo Xu Hushan Duan Liming Sun Zhiyu Chen Zhiqiang He Jianjun Li Songlin Lei Xiangguo Fu Fen Zhang Xueheng Yuan Xiaohua Du Chengming Yan Xinshuang Hu Jun Tang Shuwen Ye Ruiping Yang Kun Shi Fudong Zhang Wei Chen Ze Li Long Xu Xing Liu Longxiang Zhang Liyong Lin Qingyun Gou Boxing Xu Ge Zhou Xionghong Zhang Yuhu Xiao Guoqing | 2011 | IMP & HIRFL Annual Report2011，，1： | 4 |
| 3 | Health-related quality of life among rural residents aged 45-69 years in Hua County, Henan Province, China: Results of ESECC Trial for esophageal cancer screening with endoscopy显示文摘Objective: There have been few population-based studies evaluating health related quality of life(HRQOL) in rural populations in China, and this study aimed to assess the current status of and risk factors for HRQOL in a general rural population in high risk region of esophageal cancer in China.Methods: From November 2015 to September 2016, 12,085 permanent residents aged 45–69 years from 257 villages in the Endoscopic Screening for Esophageal Cancer in China(ESECC) trial(Clinical Trials.gov:NCT01688908) randomly selected from Hua County, Henan Province, China were interviewed. The EQ-5 D-3 L,a generic measure of HRQOL, and a questionnaire were used to assess their HRQOL and potential risk factors.Results: Among all the participants, 30.62% of the participants reported problems in at least one EQ-5 D dimension. Pain/discomfort(25.52%) was the most frequently reported problem followed by anxiety/depression(7.97%), mobility(5.82%), usual activities(2.61%) and self-care(1%). These rural residents had a mean EQ-5 D index score of 0.948, and lower EQ-5 D index scores were associated with older age, female gender, lower levels of household annual per capita income, living alone, using shallow wells as main source of drinking water, exposure to family members smoking, testiness, unhealthy dietary habits, overweight or obesity, upper gastrointestinal cancer related symptoms and chronic diseases.Conclusions: Rural residents in China have a relatively low quality of life. Health promotion programs in this population should focus on the elderly, especially elderly women and the elderly living alone. Improving basic living circumstances and primary medical care services should be priorities. Results of this study will also serve as the basis for the cost-utility evaluation in our ESECC screening trial. | Hui Wang Yaqi Pan Chuanhai Guo Fenglei Li Ruiping Xu Mengfei Liu Zhen Liu Fangfang Liu Hong Cai Yang Ke Zhonghu He | 2018 | Chinese Journal of Cancer Research2018，30，2： | 3 |
| 4 | Oral microbiome and risk of malignant esophageal lesions in a high-risk area of China:A nested case-control study显示文摘Objective:We aimed to prospectively evaluate the association of oral microbiome with malignant esophageal lesions and its predictive potential as a biomarker of risk.Methods:We conducted a case-control study nested within a population-based cohort with up to 8 visits of oral swab collection for each subject over an 11-year period in a high-risk area for esophageal cancer in China.The oral microbiome was evaluated with 16 S ribosomal RNA(rRNA)gene sequencing in 428 pre-diagnostic oral specimens from 84 cases with esophageal lesions of severe squamous dysplasia and above(SDA)and 168 matched healthy controls.DESeq analysis was performed to identify taxa of differential abundance.Differential oral species together with subject characteristics were evaluated for their potential in predicting SDA risk by constructing conditional logistic regression models.Results:A total of 125 taxa including 37 named species showed significantly different abundance between SDA cases and controls(all P<0.05&false discovery rate-adjusted Q<0.10).A multivariate logistic model including 11 SDA lesion-related species and family history of esophageal cancer provided an area under the receiver operating characteristic curve(AUC)of 0.89(95%CI,0.84-0.93).Cross-validation and sensitivity analysis,excluding cases diagnosed within 1 year of collection of the baseline specimen and their matched controls,or restriction to screenendoscopic-detected or clinically diagnosed case-control triads,or using only bacterial data measured at the baseline,yielded AUCs>0.84.Conclusions:The oral microbiome may play an etiological and predictive role in esophageal cancer,and it holds promise as a non-invasive early warning biomarker for risk stratification for esophageal cancer screening programs. | Fangfang Liu Mengfei Liu Ying Liu Chuanhai Guo Yunlai Zhou Fenglei Li Ruiping Xu Zhen Liu Qiuju Deng Xiang Li Chaoting Zhang Yaqi Pan Tao Ning Xiao Dong Zhe Hu Huanyu Bao Hong Cai Isabel Dos Santos Silva Zhonghu He Yang Ke | 2020 | Chinese Journal of Cancer Research2020，32，6： | 3 |
| 5 | Identification of cancer patients using claims data from health insurance systems: A real-world comparative study显示文摘Objective: To evaluate the accuracy of identifying cancer patients by use of medical claims data in a health insurance system in China, and provide the basis for establishing the claims-based cancer surveillance system in China.Methods: We chose Hua County, Henan Province as the study site, and randomly selected 300 and 1,200 qualified inpatient electronic medical records(EMRs) as well as the New Rural Cooperative Medical Scheme(NCMS) claims records for cancer patients in Hua County People’s Hospital(HCPH) and Anyang Cancer Hospital(ACH) in 2017. Diagnostic information for NCMS claims was evaluated on an individual level, and sensitivity and positive predictive value(PPV) were calculated taking the EMRs as the gold standard.Results: The sensitivity of NCMS was 95.2%(93.8%-96.3%) and 92.0%(88.3%-94.8%) in ACH and HCPH,respectively. The PPV of the NCMS was 97.8%(96.7%-98.5%) in ACH and 89.0%(84.9%-92.3%) in HCPH.Overall, the weighted and combined sensitivity and PPV of NCMS in Hua County was 93.1% and 92.1%,respectively. Significantly higher sensitivity and PPV in identifying patients with common cancers than noncommon cancers were detected in HCPH and ACH separately(P<0.01).Conclusions: Identification of cancer patients by use of the NCMS is accurate on individual level, and it is therefore feasible to conduct claims-based cancer surveillance in areas not covered by cancer registries in China. | Hongrui Tian Ruiping Xu Fenglei Li Chuanhai Guo Lixin Zhang Zhen Liu Mengfei Liu Yaqi Pan Zhonghu He Yang Ke | 2019 | Chinese Journal of Cancer Research2019，31，4： | 3 |
| 6 | A high-performance bio-tissue imaging method using air flow-assisted desorption electrospray ionization coupled with a high-resolution mass spectrometer显示文摘Mass spectrometry imaging (MSI) technology can simultaneously obtain the spatial distribution of thousands of chemical compounds and has unique advantages compared to other techniques that allow mapping the surface of bio-tissue. Here, we combined an air flow-assisted desorption electrospray ionization (AFADESI) MSI device with a high-resolution mass spectrometer to optimize the system parameters and achieve more accurate spatial distribution characteristics for compounds of interest while investigating bio-tissue sections. The platform set-up, required instrumentation, sample pretreatment, parameter optimization and bio-tissue characterization are described and discussed.Finally, the parameter conditions that can provide optimal ionic intensity and enhanced resolution were confirmed. The reasonable resolution and sensitivity improvements of AFADESI-MSI have been achieved through tandem a high-resolution mass spectrometer system, therefore, it would be a promising technique for the bio-tissue imaging analysis. | Yiwei Lv Tiegang Li Chengan Guo Chenglong Sun Fei Tang Luojiao Huang Zhigang Luo Xin Li Ruiping Zhang Qingce Zang Jiuming He Zeper AbliZ | 2019 | Chinese Chemical Letters2019，30，2： | 2 |
| 7 | Utilization of aluminum hydroxide waste generated in fluoride adsorption and coagulation processes for adsorptive removal of cadmium ion显示文摘尽管基于 Al 的凝结和吸附过程为氟化物(F) 移动被证明高度有效,二个过程两个都产生大量艾尔(哦)3 固体废物包含 F (艾尔(哦)3-F) 。这研究试图调查利用艾尔的可行性(哦) 在艾尔产生的 3-F (哦)3 吸附(艾尔(哦)3-F 广告 ) 和凝结(艾尔(哦)3-F 为镉离子(Cd (II )) 的吸附的 coag ) 。艾尔的吸附能力(哦)3-F 广告 和艾尔(哦)3-F 为 Cd (II ) 的 coag 作为太古的铝氢氧化物的类似(艾尔(哦) 具有 24.39 和 19.90 mg 映慬Р的 3), | Jiawei JU Ruiping LIU Zan HE Huijuan LIU Xiwang ZHANG Jiuhui QU | 2016 | Frontiers of Environmental Science & Engineering2016，10，3： | 2 |
| 8 | Spatiotemporal pharmacometabolomics based on ambient mass spectrometry imaging to evaluate the metabolism and hepatotoxicity of amiodarone in HepG2 spheroids显示文摘Three-dimensional(3D)cell spheroid models combined with mass spectrometry imaging(MSI)enables innovative investigation of in vivo-like biological processes under different physiological and pathological conditions.Herein,airflow-assisted desorption electrospray ionization-MSI(AFADESI-MSI)was coupled with 3D HepG2 spheroids to assess the metabolism and hepatotoxicity of amiodarone(AMI).High-coverage imaging of>1100 endogenous metabolites in hepatocyte spheroids was achieved using AFADESI-MSI.Following AMI treatment at different times,15 metabolites of AMI involved in Ndesethylation,hydroxylation,deiodination,and desaturation metabolic reactions were identified,and according to their spatiotemporal dynamics features,the metabolic pathways of AMI were proposed.Subsequently,the temporal and spatial changes in metabolic disturbance within spheroids caused by drug exposure were obtained via metabolomic analysis.The main dysregulated metabolic pathways included arachidonic acid and glycerophospholipid metabolism,providing considerable evidence for the mechanism of AMI hepatotoxicity.In addition,a biomarker group of eight fatty acids was selected that provided improved indication of cell viability and could characterize the hepatotoxicity of AMI.The combination of AFADESI-MSI and HepG2 spheroids can simultaneously obtain spatiotemporal information for drugs,drug metabolites,and endogenous metabolites after AMI treatment,providing an effective tool for in vitro drug hepatotoxicity evaluation. | Limei Li Qingce Zang Xinzhu Li Ying Zhu Shanjing Wen Jiuming He Ruiping Zhang Zeper Abliz | 2023 | Journal of Pharmaceutical Analysis2023，13，5： | 2 |
| 9 | A self-standing,UV-cured semi-interpenetrating polymer network reinforced composite gel electrolytes for dendrite-suppressing lithium ion batteries显示文摘A self-standing,flexible and lithium dendrite growth-suppressing composite gel polymer electrolyte membrane was designed for the use of room-temperature lithium ion batteries.The multi-functional composite semi-interpenetrating polymer network(referred to as“Cs-IPN”)electrolyte membrane was fabricated by combining a UV-cured ethoxylated trimethylolpropane triacrylate(ETPTA)macromer with alumina nanoparticles in the presence of liquid electrolyte and thermoplastic linear poly(ethylene oxide)(PEO).The polymer electrolyte membrane exhibits a semi-interpenetrating polymer network structure and a higher room temperature ionic conductivity,which impart the electrolyte with a significant cycling(120 mAh g^(-1)after 200 cycles)and a remarkable rate(137 mAh g^(-1)at 0.1℃,130 mAh g^(-1)at 0.5℃,119 mAh g^(-1)at 1℃ and 100 mAh g^(-1)at 2℃)performance in Li/LiFePO4 battery.More importantly,the polymer electrolyte possesses superior ability to inhibit the growth of lithium dendrites,which makes it promising for next generation lithium ion batteries. | Ruiping Liu Zirui Wu Peng He Haoyu Fan Zeya Huang Lei Zhang Xinshuang Chang Hang Liu Chang-an Wang Yutao Li | 2019 | Journal of Materiomics2019，5，2： | 2 |
| 10 | Comparative effect of allopolyploidy on transposable element composition and gene expression between Gossypium hirsutum and its two diploid progenitors显示文摘An allopolyploidization event formed allotetraploid Gossypium species from an A-genome diploid species and a D-genome diploid species. To explore the responses of transposable elements(TEs) to allopolyploidy, we assembled parallel TE datasets from G. hirsutum, G. arboreum and G. raimondii and analyzed the TE types and the effects of TEs on orthologous gene expression in the three Gossypium genomes.Gypsy was the most abundant TE type and most TEs were located $500 bp from genes in all three genomes. In G. hirsutum, 35.6% of genes harbored TE insertions, whereas insertions were more frequent in G. arboreum and G. raimondii. G. hirsutum had the highest proportion of uniquely matching 24-nt small interfering RNAs(siRNAs) that targeted TEs. TEs,particularly those targeted by 24-nt siRNAs, were associated with reduced gene expression, but the effect of TEs on orthologous gene expression varied substantially among species. Orthologous gene expression levels in G. hirsutum were intermediate between those of G. arboreum and G. raimondii, which did not experience TE expansion or reduction resulting from allopolyploidization. This study underscores the diversity of TEs co-opted by host genes and provides insights into the roles of TEs in regulating gene expression in Gossypium. | Hua Cheng Gaofei Sun Shoupu He Wenfang Gong Zhen Peng Ruiping Wang Zhongxu Lin Xiongming Du | 2019 | Journal of Integrative Plant Biology2019，61，1： | 2 |
| 11 | A rapid and sensitive UPLC–MS/MS method for quantitative determination of arformoterol in rat plasma, lung and trachea tissues显示文摘A rapid and sensitive ultra-performance liquid chromatography-tandem mass spectrometry(UPLC–MS/MS) method was developed and fully validated for determination of arformoterol in rat plasma, lung and trachea tissues. The chromatographic separation was performed on an Agilent XDB C8 column with gradient elution by using acetonitrile and 0.1% formic acid water. The method presented high sensitivity(LLOQ of 1.83 pg/mL for plasma and 3.90 pg/mL for lung and trachea tissue homogenates) and great linearity over the range of 1.83–458 pg/mL for plasma, 13.9–1560 pg/mL for lung and trachea tissue homogenates. No carry over effect and matrix effect were observed. The intra-and inter-day precision/accuracy were within ±15% at three quality control concentration levels. This robust method was successfully applied to the pharmacokinetic, lung and trachea tissue distribution study after inhalation administration of arformoterol tartrate inhalation solution(50 m g/kg). The in vivo information indicate that arformoterol can be rapidly absorbed into blood through respiratory systems, lung and trachea tissue maintain a certain amount of arformoterol in 1 h after dosing. | Chenglong Sun Jiuming He Hongbo Wu Xiaowei Song Jiangshuo Li Luojiao Huang Xiaoyu Xu Manjiangcuo Wang Ruiping Zhang Zeper Abliz | 2018 | Chinese Chemical Letters2018，29，8： | 2 |
| 12 | Effects of fluoride on the removal of cadmium and phosphate by aluminum coagulation显示文摘This study focuses on the effects of p H and fluoride at different molar ratios of fluoride to Al(R F:Al) on the removal of cadmium(Cd^(2+)) and phosphate by Al coagulation. Fluoride at R F:Al≥ 3:1 inhibits the removal of Cd over wide Al dose ranges from 5 to 10 mg/L as Al. The removal of phosphate decreases significantly at high R F:Al of 10:1 whereas at lowered R F:Al(i.e., ≤ 6:1), an adverse effect is observed only at insufficient Al doses below 2 mg/L. Fluoride shows inhibitive effects towards the removal of Cd at p H 7 and 8 and that of phosphate at p H 6. Fluoride decreases the ζ-potential in both systems, and the decreasing extent is positively correlated to the elevated R F:Al. The Al fluoride interactions include the formation of Al–F complexes and the adsorption of fluoride onto Al(OH)_3 precipitates, i.e., the formation of Al(OH)n F m. Al–F complex formation inhibits Al hydrolysis and increases residual Al levels, and a more significant increase was observed at lower p H. Al–F complexes at high R F:Al complicate the coagulation behavior of Al towards both negative and positive ionic species. Moreover, fluoride at low R F:Al shows little effect on Al coagulation behavior towards Cd^(2+)and phosphate, and the spent defluoridation adsorbent,i.e., aluminum(Al) hydro(oxide) with adsorbed fluoride at R F:Al of below 0.1:1, may be reclaimed as a coagulant after being dissolved. | Ruiping Liu Bao Liu Lijun Zhu Zan He Jiawei Ju Huachun Lan Huijuan Liu | 2015 | Journal of Environmental Sciences2015，27，6： | 1 |
| 13 | Molecular basis of Spns2-facilitated sphingosine-1-phosphate transport显示文摘Dear Editor,As one of the critical sphingolipid metabolites in eukaryotes,sphingosine-1-phosphate(S1P)acts as a bioactive lipid mediator in the immune and vascular systems.S1P prompts its physiological roles through two mechanisms,binding to its intracellular targets or extracellular secretion.Intracellular S1P promotes cellular proliferation,whereas plasma S1P facilitates immune cell trafficking,regulates angiogenesis,and helps to maintain vascular integrity.1 Due to the amphipathic property,S1P cannot diffuse freely but has to be transported across the cell membrane through active transport.1 In the past two decades,several S1P transporters have been identified,including two major facilitator superfamily(MFS)members:Spinster homolog 2(Spns2)and Mfsd2b,and some ATP-binding cassette family transporters.Among these transporters,Spns2 is the first identified and the most extensively studied.2 Here,we reported two cryo-electron microscopy(EM)structures of human Spns2 in inward-open conformations bound to S1P or inhibitor 16d. | Bin Pang Leiye Yu Tong Li Haizhan Jiao Xiaomei Wu Jinxin Wang Ruiping He Yurou Zhang Juan Wang Hongli Hu Wei Dai Li Chen Ruobing Ren | 2024 | Cell Research2024，34，2： | 0 |
| 14 | 2 - 30 Progress in Analyzing RIBLL1 17F+p Experimental Data显示文摘 | He Jianjun Hu Jun Xu Shiwei Chen Zhiqiang Zhang Xueying Wang Jiansong Yu Xiangqing Li Long Zhang Liyong Yang Yanyun Ma Peng Wang Hongwei Tian Wendong Zhang Xueheng Su Jun Li Ertao Hu Zhengguo Guo Zhongyan Xu Xing Yuan Xiaohua Lu Wan Lei Xiangguo Yu Yuhong Tang Shuwen Ye Ruiping Chen Jinda Jin Shilun Du Chengming Wang Shitao Ma Junbing Liu Longxiang Bai Zhen Sun Zhiyu Li Xiangqing Zhang Yuhu Zhou Xiaohong Xu Hushan | 2010 | IMP & HIRFL Annual Report2010，，1： | 0 |
| 15 | Boosting the Activity and Stability with Dual-Metal-N Couplings for Li–O_(2)Battery显示文摘Electrocatalysts with high efficiency are crucial for improving the storage capacity and electrochemical stability of lithium–oxygen batteries(LOBs).In this work,through a facile hydrothermal method,cobalt–nitrogen-doped carbon nanocubes(Co–N/C),the calcination products of zeolitic imidazolate framework(ZIF–67)are encapsulated by ultrathin C–MoS_(2) nanosheets to obtain Co–N/C@C–MoS_(2) composites which are used as host materials for the oxygen cathode.The synergistic effect between Co–N_(x) active sites and Mo–N coupling centers effectively promotes the formation and decomposition of Li_(2)O_(2) during repeated discharge and charge process.The mesoporous C–MoS_(2) nanosheets with delicately designed morphology facilitate charge transfer and account for improved reaction kinetics and more importantly,suppressed side reactions between the carbon materials and the electrolyte.The oxygen cathode with the Co–N/C@C–MoS_(2)host shows a high initial discharge specific capacity of 21197 mAh g^(-1)and a long operation life of 332 cycles.Theoretical calculation provides in-depth explanation for the reaction mechanism and offers insights for the rational design of electrocatalysts for LOBs. | Shan Wu Di Wu Dawei Zhang Wenhong Liu Hao Luo Jianbo He Qingchun Yang Zhiwei Li Ruiping Liu | 2022 | Energy & Environmental Materials2022，5，3： | 0 |
| 16 | 化学小分子诱导多能干细胞过程染色质可及性动态变化规律显示文摘文章简介尽管化学小分子诱导多能干细胞(CIP)技术有着令人振奋的潜力和应用前景,但仍存在效率低下,机制不明等问题。在本研究中,课题组开发了无需血清、不用重新传代分盘的高效两步CIP技术. | 曹尚涛 余胜勇 李东伟 Jing Ye Xuejie Yang Chen Li Xiaoshan Wang Yuanbang Mai Yue Qin Jian Wu Jiangping He Chunhua Zhou He Liu Bentian Zhao Xiaodong Shu Chuman Wu Ruiping Chen Waiyee Chan Guangjin Pan Jiekai Chen 刘晶 裴端卿 | 2019 | 科学新闻2019，0，2： | 0 |
| 17 | Adsorptive behaviors of humic acid onto freshly prepared hydrous manganese dioxides显示文摘This study focused on the adsorptive behaviors of humic acid onto freshly prepared hydrous MnO_(2)(s)(δMnO_(2)),and investigated the feasibility of employingδMnO2 for humic acid removal from drinking water.Effects of such parameters as molecular mass of humic acid,kinds of diva-lent cations on adsorptive behaviors and possible mechanisms involved were investigated.This study indicated that humic acid with higher molecular mass exhibited more tendency of adsorbing ontoδMnO2 than that with lower molecular mass.Ca^(2+)facilitated more humic acid adsorption than Mg^(2+);UV-Vis spectra analysis indicated higher capabilities of Ca^(2+)coordinating with acidic functional groups of humic acid than that of Mg2+.Additionally,ζpotential characterization indicated that Ca^(2+)showed higher potential of increasingζpotential ofδMnO_(2) than Mg^(2+).Ca^(2+)of 1.0 mmol/L increasedζpotential ofδMnO2 from−37 mV(pH 7.9)to+7 mV(pH 7.2),while 1.0 mmol/L Mg^(2+)^increased to lower value as−9 mV(pH 6.5),correspondingly.Fourier transform infrared(FTIR)spectra demonstrated the adsorption of humic acid ontoδMnO_(2),showing the important roles of-COO−function-al groups and surface Mn-OH in the adsorption of humic acid ontoδMnO_(2). | LIU Ruiping YANG Yanling LI Guibai HE Wenjie HAN Hongda | 2007 | Frontiers of Environmental Science & Engineering2007，1，2： | 0 |
| 18 | Spatiotemporally resolved metabolomics and isotope tracing reveal CNS drug targets显示文摘Deconvolution of potential drug targets of the central nervous system(CNS)is particularly challenging because of the complicated structure and function of the brain.Here,a spatiotemporally resolved metabolomics and isotope tracing strategy was proposed and demonstrated to be powerful for deconvoluting and localizing potential targets of CNS drugs by using ambient mass spectrometry imaging.This strategy can map various substances including exogenous drugs,isotopically labeled metabolites,and various types of endogenous metabolites in the brain tissue sections to illustrate their microregional distribution pattern in the brain and locate drug action-related metabolic nodes and pathways.The strategy revealed that the sedative-hypnotic drug candidate YZG-331 was prominently distributed in the pineal gland and entered the thalamus and hypothalamus in relatively small amounts,and can increase glutamate decarboxylase activity to elevateγ-aminobutyric acid(GABA)levels in the hypothalamus,agonize organic cation transporter 3 to release extracellular histamine into peripheral circulation.These findings emphasize the promising capability of spatiotemporally resolved metabolomics and isotope tracing to help elucidate the multiple targets and the mechanisms of action of CNS drugs. | Bo Jin Xuechao Pang Qingce Zang Man Ga Jing Xu Zhigang Luo Ruiping Zhang Jiangong Shi Jiuming He Zeper Abliz | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 0 |
| 19 | Investigation of Proton Resonant Properties in laNe via 17F+p and Its Astrophysical Implications for 14O(α,p)17F Stellar Reaction显示文摘 | Hu Jun He Jianjun Xu Shiwei Chen Zhiqiang Zhang Xueying Wang Jiansong Yu Xiangqing Li Long Zhang Liyong Yang Yanyun Ma Peng Wang Hongwei Tian Wendong Yuan Xiaohua Lu Wan Zhang Xueheng SuJun Li Ertao Hu Zhengguo Guo Zhongya n Xu Xing Lei Xiangguo Yu Yuhong Tang Shuwen Ye Ruiping Chen Jinda Jin Shilun Du Chengming Wang Shitao Ma Junbing Liu Longxiang Bai Zhen Sun Zhiyu Li Xiangqing Zhang Yuhu Zhou Xiaohong Xu Hushan | 2009 | 近代物理研究所和兰州重离子加速器实验室年报:英文版2009，，1： | 0 |
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