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| 1 | COVID-19 containment: China provides important lessons for global response显示文摘The world must act fast to contain wider international spread of the epidemic of COVID-19 now.The unprecedented public health efforts in China have contained the spread of this new virus.Measures taken in China are currently proven to reduce human-to-human transmission successfully.We summarized the effective intervention and prevention measures in the fields of public health response,clinical management,and research development in China,which may provide vital lessons for the global response.It is really important to take collaborative actions now to save more lives from the pandemic of COVID-19. | Shuxian Zhang Zezhou Wang Ruijie Chang Huwen Wang Chen Xu Xiaoyue Yu Lhakpa Tsamlag Yinqiao Dong Hui Wang Yong Cai | 2020 | Frontiers of Medicine2020，14，2： | 11 |
| 2 | Estimation of reproduction numbers of COVID-19 in typical countries and epidemic trends under different prevention and control scenarios显示文摘The coronavirus disease 2019(COVID-19)has become a life-threatening pandemic.The epidemic trends in different countries vary considerably due to different policy-making and resources mobilization.We calculated basic reproduction number(R0)and the time-varying estimate of the effective reproductive number(Rt)of COVID-19 by using the maximum likelihood method and the sequential Bayesian method,respectively.European and North American countries possessed higher (R0)and unsteady Rt fluctuations,whereas some heavily affected Asian countries showed relatively low (R0)and declining Rt now.The numbers of patients in Africa and Latin America are still low,but the potential risk of huge outbreaks cannot be ignored.Three scenarios were then simulated,generating distinct outcomes by using SEIR(susceptible,exposed,infectious,and removed)model.First,evidence-based prompt responses yield lower transmission rate followed by decreasing Rt.Second,implementation of effective control policies at a relatively late stage,in spite of huge casualties at early phase,can still achieve containment and mitigation.Third,wisely taking advantage of the time-window for developing countries in Africa and Latin America to adopt adequate measures can save more people’s life.Our mathematical modeling provides evidence for international communities to develop sound design of containment and mitigation policies for COVID-19. | Chen Xu Yinqiao Dong Xiaoyue Yu Huwen Wang Lhakpa Tsamlag Shuxian Zhang Ruijie Chang Zezhou Wang Yuelin Yu Rusi Long Ying Wang Gang Xu Tian Shen Suping Wang Xinxin Zhang Hui Wang Yong Cai | 2020 | Frontiers of Medicine2020，14，5： | 8 |
| 3 | Phase-and epidemic region-adjusted estimation of the number of coronavirus disease 2019 cases in China显示文摘The outbreak of the coronavirus disease 2019 in China was first reported in Wuhan in December 2019 and gradually spread to other areas in China.After implementation of prevention and control measures,the estimation of the epidemic trend is needed.A phase-and region-adjusted SEIR model was applied for modeling and predicting the number of cases in Wuhan,Hubei Province and regions outside Hubei Province in China.The estimated number of infections could reach its peak in late February 2020 in Wuhan and Hubei Province,which is 55303–84520 and 83944–129312,respectively,while the epidemic peaks in regions outside Hubei Province in China could appear on February 13,2020 with the estimated 13035–19108 cases.According to the estimation,the outbreak would abate in March and April all over China.Current estimation provided evidence for planned work resumption under stringent prevention and control in China to further support the fight against the epidemic.Nevertheless,there is still possibility of the second outbreak brought by the work resumption and population migration,especially from Hubei Province and high intensity cities outside Hubei Province.Strict prevention and control measures still need to be considered in the regions with high intensity of epidemic and densely-populated cities. | Ruijie Chang Huwen Wang Shuxian Zhang Zezhou Wang Yinqiao Dong Lhakpa Tsamlag Xiaoyue Yu Chen Xu Yuelin Yu Rusi Long Ning-Ning Liu Qiao Chu Ying Wang Gang Xu Tian Shen Suping Wang Xiaobei Deng Jinyan Huang Xinxin Zhang Hui Wang Yong Cai | 2020 | Frontiers of Medicine2020，14，2： | 2 |
| 4 | Long noncoding RNAs as diagnostic biomarkers associated with cancer phenotypes显示文摘Increasing evidence suggests that long noncoding RNAs(lncRNAs) play vital roles in the transformation and maintenance of cancer phenotypes and have important clinical implications. These lncRNAs control important aspects of tumor biology, including proliferation, angiogenesis, metastasis, and the microenvironment by regulating RNA and protein interactions or through their ability to base pair with RNA and DNA. In this study, we review the mechanism of the function of lncRNAs in cancer and their diagnostic roles in cancer phenotypes, which make them attractive as non-invasive biomarkers from body fluid samples for different types of cancer. | Huili Luo Ruijie Chang Xiulan Chen | 2018 | Oncology and Translational Medicine2018，4，4： | 1 |
| 5 | New glycosides from Dracocephalum tanguticum maxim显示文摘 | Qi Zeng Ruijie Chang Jiangjiang Qin | 2011 | Archives of pharmacal research2011，34，12： | 1 |
| 6 | An Efficient Method of Generating Parameters for Pairing-Based Cryptosystems显示文摘Efficient computation of Tate pairing is a crucial factor for practical applications of pairing-based cryptosystems(PBC).Recently,there have been many improvements for the computation of Tate pairing,which focuses on the arithmetical operations above the finite field.In this paper,we analyze the structure of Miller’s algorithm firstly,which is used to implement Tate pairing.Based on the characteristics that Miller’s algorithm will be improved tremendous if the order of the subgroup of elliptic curve group is low hamming prime,a new method for generating parameters for PBC is put forward,which enable it feasible that there is certain some subgroup of low hamming prime order in the elliptic curve group generated.Finally,we analyze the computation efficiency of Tate pairing using the new parameters for PBC and give the test result.It is clear that the computation of Tate pairing above the elliptic curve group generating by our method can be improved tremendously. | WANG Maocai DAI Guangming PEN Lei ZHEN Chang QIN Ruijie | 2010 | China Communications2010，7，4： | 0 |
| 7 | Neuromodulation of Chemical Synaptic Transmission Driven by THz Photons显示文摘Postsynaptic currents of chemical synapse are modulated by multitudinous neurotransmitters,such as acetylcholine,dopamine,glutamate,andγ-aminobutyric acid,many of which have been used in the treatment of neurological diseases.Here,based on molecular dynamics simulations and quantum chemical calculation,we propose that 30-to 45-THz photons can resonate with a variety of typical neurotransmitter molecules and make them absorb photon energy to activate the transition to high energy state,which is expected to be a new method of neural regulation.Furthermore,we verified the calculated results through experiments that THz irradiation could substantively change neuronal signal emission and enhance the frequency,amplitude,and dynamic properties of excitatory postsynaptic current and inhibitory postsynaptic current.In addition,we demonstrated the potential of neural information regulation by THz photons through 2-photon imaging in vivo.These findings are expected to improve the understanding of the physical mechanism of biological phenomena and facilitate the application of terahertz technology in neural regulation and the development of new functional materials. | Xiaoxuan Tan Yuan Zhong Ruijie Li Chao Chang | 2023 | Research2023，，3： | 0 |
| 8 | The bioactive of four dietary sources phospholipids on heavy metal-induced skeletal muscle injury in zebrafish:A comparison of phospholipid profiles显示文摘Phospholipids have been recognized as significant functional lipids related to nutrition,while they were complex and multiple,and their sources were various.Bioactive functions of phospholipids in skeletal muscle were given serious attention;however,studies on dietary phospholipid profiles with functions on skeletal muscle were rarely reported.Here,we analyzed phospholipid profiles of four kinds of dietary phospholipids(including yolk phospholipid,soybean phospholipid,perilla seed phospholipid and krill oil phospholipid)and compared their composition differences using UPLC-Q-TOF-MS.Lipidomics emphasized significant differences in compositions.Krill oil phospholipid rich inω-3 long-chain polyunsaturated fatty acids(ω-3 LCPUFAs)showed the most excellent effect in skeletal muscle protection.Compared with triglyceride-type lipid(fish oil),phospholipids had higher bioavailability.Besides,as for a higher degree of unsaturation of phospholipid,they did not always perform better effects,which might be related to being more susceptible to suffering from oxidative stress.Overall,four representative phospholipids were analyzed and compared for their bioactive function in skeletal muscle,providing a reference for better understanding relationships between structures and functional applications of phospholipids. | Zhangtie Wang Emad Karrar Yandan Wang Ruijie Liu Ming Chang Xingguo Wang | 2022 | Food Bioscience2022，47，3： | 0 |
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