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| 1 | Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD) is today considered the most common form of chronic liver disease, affecting a high proportion of the population worldwide. NAFLD encompasses a large spectrum of liver damage, ranging from simple steatosis to steatohepatitis, advanced fibrosis and cirrhosis. Obesity, hyperglycemia, type 2 diabetes and hypertriglyceridemia are the most important risk factors. The pathogenesis of NAFLD and its progression to fibrosis and chronic liver disease is still unknown. Accumulating evidence indicates that mitochondrial dysfunction plays a key role in the physiopathology of NAFLD, although the mechanisms underlying this dysfunction are still unclear. Oxidative stress is considered an important factor in producing lethal hepatocyte injury associated with NAFLD. Mitochondrial respiratory chain is the main subcellular source of reactive oxygen species(ROS), which may damage mitochondrial proteins, lipids and mitochondrial DNA. Cardiolipin, a phospholipid located at the level of the inner mitochondrial membrane, plays an important role in several reactions and processes involved in mitochondrial bioenergetics as well as in mitochondrial dependent steps of apoptosis. This phospholipid is particularly susceptible to ROS attack. Cardiolipin peroxidation has been associated with mitochondrial dysfunction in multiple tissues in several physiopathological conditions, including NAFLD. In this review, we focus on the potential roles played by oxidative stress and cardiolipin alterations in mitochondrial dysfunction associated with NAFLD. | Giuseppe Paradies Valeria Paradies Francesca M Ruggiero Giuseppe Petrosillo | 2014 | World Journal of Gastroenterology2014，20，39： | 50 |
| 2 | Role of rumination in the relationship between metacognition and shyness显示文摘AIM To explore the association between metacognitive beliefs, rumination and shyness in a non-clinical sample of adults. METHODS One hundred and three healthy subjects from the general population were enrolled in the study. Shyness was evaluated using the Revised Cheek and Buss Shyness Scale, rumination was assessed using the Ruminative Response Scale, metacognition was evaluated using the MetaCognitions Questionnaire 30, and anxiety levels were measured using the State Trait Anxiety Inventory form Y. Correlation analyses, mediation models and 95% bias-corrected and accelerated(BCaCI) bootstrapped analyses were performed. Mediation analyses were adjusted for sex and anxiety. RESULTS Shyness, rumination and metacognition were significantly correlated(P < 0.05). The relationship between metacognition and shyness was fully mediated by rumination(Indirect effect: 0.20; 95% BCaCI: 0.08-0.33).CONCLUSION These findings suggest an association between metacognition and shyness. Rumination mediated the relationship between metacognition and shyness, suggesting that rumination could be a cognitive strategy for shy people. Future research should explore the relationship between these constructs in more depth. | Sara Palmieri Giovanni Mansueto Simona Scaini Francesca Fiore Sandra Sassaroli Giovanni M Ruggiero Rosita Borlimi Bernardo J Carducci | 2018 | World Journal of Psychiatry2018，8，4： | 2 |
| 3 | Ca2* -induced reactive oxygen species production promotes Cytochrome e re- lease from rat liver mitochondria via mitochondrial permeability transition (MPT)-dependent and MPT-independent mecha- nisms= Role of cardiolipin显示文摘 | PetrnsilloG Ruggiero FM Pistolese M | 2004 | J Biol Chem2004，279，53： | 1 |
| 4 | Isolation of endogenous anti- coagulant N-sulfated glycosaminoglycans in human plasma from healthy subjects 显示文摘 | Ruggiero M Melli M Parma B | 2002 | Pathophysiol Haemost Thromb2002，32，： | 1 |
| 5 | Stages of change for healthy eating in diabetes显示文摘 | Vallis M Ruggiero L Greene G | 2003 | Diabetes Care2003，26，5： | 1 |
| 6 | Targeting the Toll-like receptor/interleukin 1receptor pathway in human diseases:rational design of MyD88inhibitors显示文摘 | LOIARRO M RUGGIERO V SETTE C | 2013 | Clin Lymphoma Myeloma Leuk2013，13，： | 1 |
| 7 | Stages of change for healthy eating in diabetes显示文摘 | Vallis M Ruggiero L Greene G | 2003 | Diabetes Care2003，26，： | 1 |
| 8 | Reactive oxygen species generated from the mitochondrial electron transport chain induce cytochrome c dissociation from beef-heart submitochondrial particles via cardiolipin peroxidation, possible role in the apoptosis显示文摘 | PETROSILLO G RUGGIERO F M PISTOLESE M | 2002 | FEBS Letters2002，509，： | 1 |
| 9 | Analysis of energy saving using natural ventilation in a traditional Italian building 显示文摘 | CARDINALE N MICUCCI M RUGGIERO F | 2003 | Energy and Buildings2003，35，2： | 1 |
| 10 | DHEA supplementation improves fol icular microenviroment in poor responder patients显示文摘 | Artini PG Simi G Ruggiero M | | 0，，09： | 1 |
| 11 | Severe hyperleukocytosis and multifocal intracranial haemorrhage:not always a fatal outcome显示文摘 | ANTONIO RUGGIERO AE G ATTINA AE M PIASTRA AE P | 2009 | Int J Hematol2009，90，： | 1 |
| 12 | A case of acute lymphoblastic leukemia presenting as severe hypercalcemia显示文摘 | Buonuomo PS Ruggiero A Piastra M | 2004 | J Pediatr Hematol Oncol2004，21，6： | 1 |
| 13 | Mutational analysis iden- tifies residues crucial for homodimerization of myeloid difterentia- tion factor 88( MyD88 ) and for its function in immune cells显示文摘 | Loiarro M Volpe E Ruggiero V | 2013 | J Biol Chem2013，288，30： | 1 |
| 14 | Early reconstruction failures after multilevel cervical corpectomy显示文摘 | Sasso R C Ruggiero R A Jr Reilly T M | 2003 | Spine2003，28，1： | 1 |
| 15 | Perfectionism in depression, obsessivecompulsive disorder and eating disorders显示文摘 | Sassaroli S Lauro L J Ruggiero G M | 2008 | Behav Res Ther2008，46，6： | 1 |
| 16 | Changes in the mesenteric lymph proteome induced by hemorrhagic shock 显示文摘 | Mittal A Middleditch M Ruggiero K | 2010 | Shock2010，34，2： | 1 |
| 17 | Modulation of the neuronal glutamate transporter EAACI by the interacting protein GTRAP3-18 显示文摘 | LIN C I ORLOV I RUGGIERO A M | 2001 | Nature2001，410，6824： | 1 |
| 18 | Disruption of Trkb-mediated signaling induces disassembly of postsynaptic receptor clusters at neuromuscular junctions显示文摘 | Gonzalez M Ruggiero F P Chang Q | | 0，，03： | 1 |
| 19 | Standardization of teleradiology using dicom E-mail: recommendations of the German Radiology society显示文摘 | Weisser G Walz M Ruggiero S | 2006 | Eur Radiol2006，16，3： | 1 |
| 20 | Ca^2+ - induced reactive oxygen species production promotes cytochrome e release from rat liver mitochondria via mitochondrial permeability transition (MPT)- dependent and MPT - independent mechanisms: Role of cardiolipin 显示文摘 | Petrosillo G Ruggiero FM Pistolese M | 2004 | J Biol Chem2004，279，53： | 1 |
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