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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Pathologic features of Hashimoto’s-associated papillary thyroid carcinomas显示文摘 | Marcello Di Pasquale Jay L Rothstein Juan P Palazzo | 2001 | Human Pathology2001，，1： | 2 |
| 3 | Perinatal hypoxia-ischemia induces apoptotic and excitotoxic death of periventricular white matter oligodendrocyte progenitors显示文摘 | Ness J K Romanko M J Rothstein R P | 2001 | Dev Neurosci2001，23，3： | 1 |
| 4 | Drag reduction in turbulent flows over superhydrophobic surfaces显示文摘 | Daniello R J Waterhouse N E Rothstein J P | 2009 | Physics of Fluids2009，21，8： | 1 |
| 5 | Laminar drag reduction in microchannels using ultrahydrophobic surfaces 显示文摘 | Ou J Perot B Rothstein J P | 2004 | Physics of Fluids (S1070-6631)2004，16，12： | 1 |
| 6 | Direct velocity measurements of the flow past drag-reducing ultrahydrophobic surfaces 显示文摘 | Ou J Rothstein J P | 2005 | Physics of Fluids (S1070-6631)2005，17，10： | 1 |
| 7 | Extensional Rheology ofShear-thickening Fumed Silica Nanoparticles Dispersed inan Aqueous Polyethylene Oxide Solution 显示文摘 | Khandavalli S Rothstein J P | 2014 | Journal ofRheology2014，58，2： | 1 |
| 8 | Kinetics of nitrogen uptake by Populus tremuloides in relation to atmospheric CO2 and soil nitrogen availability显示文摘 | Rothstein D E Zak D R Pregitzer K S Curtis P S | 2000 | Tree Physiology2000，20，4： | 1 |
| 9 | Cytomegalovirus cecal ulcer in a patient awai-ting cardiac transplantation显示文摘 | Pfau P Rothstein RD | | 0，，： | 1 |
| 10 | Laminar Drag Reduction in Microchannels Using Ultrahydrophobic Surfaces显示文摘 | Ou J Perot B Rothstein J P | | 0，，12： | 1 |
| 11 | Targeting of both the c- Met and EGFR pathways results in additive inhibition of lung tumorigenesis in transgenic mice 显示文摘 | Stabile LF Rothstein ME Keohavong P | 2010 | Cancers2010，2，4： | 1 |
| 12 | Control of the sharkskin instability in the extrusion of polymer melts using induced temperature gradients显示文摘 | Erik Miller Jonathan P Rothstein | 2004 | Rheologica Acta2004，44，2： | 1 |
| 13 | Drag reduction in turbulent flows over superhydrophobic surfaces显示文摘 | DANIELLO R J WATERHOUSE N E ROTHSTEIN J P | 2009 | Phys Fluids2009，，： | 1 |
| 14 | Laminar drag reduction in naicrochannels using ultrahydrophobic surfaces 显示文摘 | Ou J Perot B Rothstein J P | 2004 | Physics of Fluids ( 1994 - present )2004，16，12： | 1 |
| 15 | Laminar drag reduction in microchannels using ultrahydrophobic surfaces 显示文摘 | OU J BLAIR P ROTHSTEIN J P | 2004 | Physics of Fluids2004，16，12： | 1 |
| 16 | Direct velocity measurements of the flow past drag - reducing uhrahydrophobic surfaces 显示文摘 | Ou J Rothstein J P | 2005 | Physics of Fluids ( 1994 - present)2005，17，10： | 1 |
| 17 | Direct velocity measurements of the flow past drag-reducing ultrahydrophobic surfaces显示文摘 | OU J ROTHSTEIN J P | 2005 | Physics of Fluids2005，17，113： | 1 |
| 18 | Human response to predicated Apollo landing impact in selected body orientations 显示文摘 | Brown W K Rothstein T D Foster L P | 1966 | Aerospace Med1966，37，1： | 1 |
| 19 | Pathologic features of Hashimoto′s-associated papillary thyroid carcinomas显示文摘 | Pasquale M D Rothstein J L and Palazzo J P | 2001 | Hum Pathol2001，32，： | 1 |
| 20 | Pathologic features of Hashimoto's-associated papillary thyroid carcinomas显示文摘 | Di Pasquale M Rothstein J L Palazzo J P | 2001 | Hum Pathol2001，32，： | 1 |
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