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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Glutanate transporter protein subtypes are expressed differentially during rat CNS development显示文摘 | Furuta A Rothstein J D Martin L J | 1997 | J Neurosci1997，17，： | 1 |
| 3 | Two members of the thioredoxin-h family interact with the kinase domain of a Brassica S-locus receptor kinase 显示文摘 | Bower M S Matias D D Femandes-carvalho E Mazzurco M Gu T Rothstein A J and Goring D R | 1996 | Plant Cell1996，8，： | 1 |
| 4 | Localization of neuronal and glial glutamate transporters显示文摘 | Rothstein J D Martin L Levey A I | 1994 | Neuron1994，13，3： | 1 |
| 5 | Knockout of glutamate transporters reveals a major role for astroglial transportin excitotoxicity and clearance of glutamate显示文摘 | Rothstein J D Dykes-Hoberg M Pardo C A | 1996 | Neuron1996，16，3： | 1 |
| 6 | Kuncl RW: localization of neuronal and glial glutamate transporter 显示文摘 | Rothstein J D Martin L Levey A I | 1994 | Neurons1994，13，： | 1 |
| 7 | The development of dysplasia and adenocarcinoma during endoscopic surveillance of Barrett's esophague 显示文摘 | Katz D Rothstein R Lindgren A | 1998 | Am J Gartroenterol1998，93，4： | 1 |
| 8 | Geothermal gradients in continental magmatic arcs: Constraints from the eastern Peninsular Ranges batholith, Baja California, Mexico显示文摘 | Rothstein D A Manning C E | 2003 | Geological Society of America2003，374，： | 1 |
| 9 | Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate显示文摘 | Rothstein J D Dykes-Hoberg M Pardo C A | 1996 | Neuron1996，16，3： | 1 |
| 10 | Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class molecules显示文摘 | ROCK K L GRAMM C ROTHSTEIN L CLARK K STEIN K DICK L HWANG D GOLDBERG A L | 1994 | Cell1994，78，5： | 1 |
| 11 | A hybrid vertical mixing scheme and its application to tropical ocean models显示文摘 | CHEN D ROTHSTEIN L M BUSALACCHI A J | 1994 | Jour- nal of Physical Oceanography1994，24，10： | 1 |
| 12 | The self-incompatibility phenotype in Brassica is altered by the transformation of a mutant S locus receptor kinase显示文摘 | STAHL R J ARNOLDO M A GLAVIN T L GORING D R ROTHSTEIN S J | 1998 | Plant Cell1998，10，： | 1 |
| 13 | The development of dysplasia and adenocarcinoma during endoscopic surveillance of Barrett : s e:phagus显示文摘 | Katz D Rothstein R Schned A | 1998 | Am J Gastroenterol1998，93，： | 1 |
| 14 | Quantifying threats to imperiled species in the United States显示文摘 | Wilcove D S Rothstein D R Dubow J Philliips A and Losos F E | 1998 | BioScience1998，48，8： | 1 |
| 15 | A hybrid vertical mixing scheme and its application to tropical ocean models显示文摘 | CHEN D ROTHSTEIN L M BUSALACCHI A J | 1994 | Journal of Physical Oceanography1994，24，： | 1 |
| 16 | Quantifying threats to imperiled species in the United States 显示文摘 | Wilcove D S Rothstein D Dubow J Phillips A and Losos E | 1998 | Bioscience1998，48，8： | 1 |
| 17 | Alterations in glutamate transporter protein levels in kindling-induced epilepsy显示文摘 | MILLER H P LEVEY A I ROTHSTEIN J D | 1997 | J Neurochem1997，68，4： | 1 |
| 18 | Loss and recovery of ecosystem carbon pools following stand-replacing wildfire in Michigan jack pine forests显示文摘 | Rothstein D E Yermakov Z Buell A L | 2004 | Canadian Journal of Forest Research2004，34，9： | 1 |
| 19 | A hybrid vertical mixing scheme and its application to tropical ocean models显示文摘 | Chen D Rothstein L M Busalacchi A J | 1994 | Journal of Physical Oceanography1994，24，10： | 1 |
| 20 | Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking显示文摘 | Laird F M Farah M H Ackerley S Hoke A Maragakis N Rothstein J D | 2008 | J Neurosci2008，28，： | 1 |
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