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| 1 | National trends in resection of the distal pancreas显示文摘AIM:To investigate national trends in distal pancreatectomy(DP) through query of three national patient care databases.METHODS:From the Nationwide Inpatient Sample(NIS,2003-2009),the National Surgical Quality Improvement Project(NSQIP,2005-2010),and the Surveillance Epidemiology and End Results(SEER,2003-2009) databases using appropriate diagnostic and procedural codes we identified all patients with a diagnosis of a benign or malignant lesion of the body and/or tail of the pancreas that had undergone a partial or distal pancreatectomy.Utilization of laparoscopy was defined in NIS by the International Classification of Diseases,Ninth Revision correspondent procedure code;and in NSQIP by the exploratory laparoscopy or unlisted procedure current procedural terminology codes.In SEER,patients were identified by the International Classification of Diseases for Oncology,Third Edition diagnosis codes and the SEER Program Code Manual,third edition procedure codes.We analyzed the databases with respect to trends of inpatient outcome metrics,oncologic outcomes,and hospital volumes in patients with lesions of the neck and body of the pancreas that underwent operative resection.RESULTS:NIS,NSQIP and SEER identified 4242,2681 and 11 082 DP resections,respectively.Overall,laparoscopy was utilized in 15%(NIS) and 27%(NSQIP).No significant increase was seen over the course of the study.Resection was performed for malignancy in 59%(NIS) and 66%(NSQIP).Neither patient Body mass index nor comorbidities were associated with operative approach(P = 0.95 and P = 0.96,respectively).Mortality(3% vs 2%,P = 0.05) and reoperation(4% vs 4%,P = 1.0) was not different between laparoscopy and open groups.Overall complications(10% vs 15%,P < 0.001),hospital costs [44 741 dollars,interquartile range(IQR) 28 347-74 114 dollars vs 49 792 dollars,IQR 13 299-73 463,P = 0.02] and hospital length of stay(7 d,IQR 4-11 d vs 7 d,IQR 6-10,P < 0.001) were less when laparoscopy was utilized.One and two year survival after resection for malignancy were unchanged over the course of the study(ductal adenocarinoma 1-year 63.6% and 2-year 35.1%,P = 0.53;intraductal papillary mucinous neoplasm and nueroendocrine 1-year 90% and 2-year 84%,P = 0.25).The majority of resections were performed in teaching hospitals(77% NIS and 85% NSQIP),but minimally invasive surgery(MIS) was not more likely to be used in teaching hospitals(15% vs 14%,P = 0.26).Hospitals in the top decile for volume were more likely to be teaching hospitals than lower volume deciles(88% vs 43%,P < 0.001),but were no more likely to utilize MIS at resection.Complication rate in teaching and the top decile hospitals was not significantly decreased when compared to non-teaching(15% vs 14%,P = 0.72) and lower volume hospitals(14% vs 15%,P = 0.99).No difference was seen in the median number of lymph nodes and lymph node ratio in N1 disease when compared by year(P = 0.17 and P = 0.96,respectively).CONCLUSION:There appears to be an overall underutilization of laparoscopy for DP.Centralization does not appear to be occurring.Survival and lymph node harvest have not changed. | Armando Rosales-Velderrain Steven P Bowers Ross F Goldberg Tatyan M Clarke Mauricia A Buchanan John A Stauffer Horacio J Asbun | 2012 | World Journal of Gastroenterology2012，18，32： | 8 |
| 2 | Activity of Crizotinib (PF02341066), a Dual Mesenchymal-Epithelial Transition (MET) and Anaplastic Lymphoma Kinase (ALK) Inhibitor, in a Non-small Cell Lung Cancer Patient with De Novo MET Amplification显示文摘 | Sai-Hong Ignatius Ou Eunice L. Kwak Christina Siwak-Tapp Joni Dy Kristin Bergethon Jeffrey W. Clark D. Ross Camidge Benjamin J. Solomon Robert G. Maki Yung-Jue Bang Dong-Wan Kim James Christensen Weiwei Tan Keith D. Wilner Ravi Salgia A. John Iafrate | 2011 | Journal of Thoracic Oncology2011，，5： | 2 |
| 3 | Locali- zation of MYOC transcripts in human eye and optic nerve by in situ hybridization显示文摘 | Swiderski RE Ross JL Fingert JH Clark AF Alward WL | 2000 | Invest Ophthalmol Vis Sc/2000，41，1： | 1 |
| 4 | Validity of the Microsoft Kinect for Assessment of Postural Control 显示文摘 | Ross A : Clark Yong-Hao Pua | 2012 | Gait & Posture2012，36，3： | 1 |
| 5 | Cyclooxygenase-2 immunoreactivity in the human brain following cerebral ischemia显示文摘 | C. Iadecola Colleen Forster Shigeru Nogawa H. Brent Clark M. Elizabeth Ross | 1999 | Acta Neuropathologica1999，，1： | 1 |
| 6 | Divergent metabolic outcomes arising from targeted manipulation of the gut microbiota in diet-induced obesity 显示文摘 | Murphy EF Cotter PD Hogan A O'Sullivan O Joyce A Fouhy F Clarke SF Marques TM O'Toole PW Stanton C Quigley EM Daly C Ross PR OtDoherty RM Shanahan F | 2013 | Gut2013，62，2： | 1 |
| 7 | Surgical Shunting versus Transjugular Intrahepatic Portasystemic Shunting for Bleeding Varices Resulting from Portal Hypertension and Cirrhosis: A Meta-Analysis显示文摘 | Clark Whalen Hernandez Jonathan McKeon Brianne Villadolid Desiree Al-Saadi Sam Mullinax John Ross Sharona B Rosemurgy Alexander S | 2010 | The American Surgeon2010，，8： | 1 |
| 8 | Effect of age on contrast sensitivity function:uniocular and binocular findings显示文摘 | Ross JE Clarke DD Bron AJ | | 0，，01： | 1 |
| 9 | JD induced pluripotent stem cell–derived hepatocytes faithfully recapitulate the pathophysiology of familial hypercholesterolemia显示文摘 | Max A. Cayo Jun Cai Ann DeLaForest Fallon K. Noto Masato Nagaoka Brian S. Clark Ross F. Collery Karim Si‐Tayeb Stephen A. Duncan | 2012 | Hepatology2012，，6： | 1 |
| 10 | Isothiocyanatoporphyrins,useful intermediates for the conjugation of porphyrins with biomolecules and solid sup ports显示文摘 | Oliver J Clarke Ross W Boyle | 1999 | Chem Commun1999，，21： | 1 |
| 11 | Arsenic-stimulated liver sinusoidal capillarization in mice requires NADPH oxidase-generated superoxide显示文摘 | Straub Adam C Clark Katherine A Ross Mark A Chandra Ashwin G Li Song Gao Xiang Pagano Patrick J Stolz Donna B Barchowsky Aaron | 2008 | Journal of Clinical Investigation2008，，12： | 1 |
| 12 | The growth hormone and insulinlike growth factor axis:Its manipulation foe benefit of growth disorders in renal failure显示文摘 | Vincent Roelfema Ross G Clark | 2001 | J Am Soc Nephrol2001，12，： | 1 |
| 13 | Insulin-like growth Factor-1 stimulation of lymphopoiesis显示文摘 | Ross Clark Josef Strasser Susan McCabe | 1993 | The American Society for Clinical Investigation1993，92，： | 1 |
| 14 | Delayed hard palate repair: The philosophy revisited 显示文摘 | Wizel MA Clarke JA Ross RB | 1984 | Cleft Palate J1984，21，4： | 1 |
| 15 | The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response 显示文摘 | Muruve DA Petrilli V Zaiss AK White LR Clark SA Ross PJ | 2008 | Nature2008，452，7183： | 1 |
| 16 | Natural orifice translumenal endoscopic surgery applications in clinical practice显示文摘To review natural orifice translumenal endoscopic surgery (NOTES) applications in clinical practice and assess the evidence base for each application as reported in the literature.An electronic literature search was performed.Inclusion criteria were publications relating to NOTES applications in humans.For each type of operation the highest level of evidence available for clinical NOTES publications was evaluated.Morbidity and short-term operative outcomes were compared with gold standard published evidence where available.Finally,registered trials recruiting patients for NOTES applications were identified.Human NOTES publications with the highest level of evidence in each application are identified.There were no RCTs in the literature to date.The strongest evidence came in the form of large,multi-centre trials with 300-500 patients.The results are encouraging,comparable with gold standard techniques on morbidity and mortality.While short-term operative outcomes were also simi-lar when compared to the gold standard techniques,other than improved cosmesis little else can definitely be concluded as a clear benefit of a NOTES procedure.The most common procedures are cholecystectomy,appendicectomy and peritoneoscopy mainly performed via transvaginal access.It is evident that morbidity appears to be higher when the transgastric route is used.The safety profile of hybrid NOTES transvaginal procedures is beginning to be confirmed as is evident from the large number of procedures presented in this review.A number of authors have presented work on pure NOTES procedures but the results are inconsistent and thus the vast majority of NOTES procedures worldwide are performed in a hybrid fashion with a variable amount of laparoscopy.This review of the clinical applications of NOTES summarises the growing evidence behind this surgical discipline and highlights NOTES procedures with an acceptable safety profile. | Ross S Coomber Mikael H Sodergren James Clark Julian Teare Ara Darzi | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，3： | 1 |
| 17 | A nocturnal enuresis service for a deprived inner city显示文摘 | Tappin DM Clarke L Ross LM | 2003 | Acta Paediatr2003，92，1： | 1 |
| 18 | The Prevention Research Centers’ Managing Epilepsy Well Network显示文摘 | Colleen K. DiIorio Yvan A. Bamps Ariele L. Edwards Cam Escoffery Nancy J. Thompson Charles E. Begley Ross Shegog Noreen M. Clark Linda Selwa Shelley C. Stoll Robert T. Fraser Paul Ciechanowski Erica K. Johnson Rosemarie Kobau Patricia H. Price | 2010 | Epilepsy and Behavior2010，，3： | 1 |
| 19 | Mammalian artificial chromo- some formation from circular alphoid input DNA does not require telomere repeats 显示文摘 | EBERSOLE T A ROSS A CLARK E | 2000 | Hum Mol Genet2000，9，11： | 1 |
| 20 | Waste propellants and smokeless powders as ingredients in com- mercial explosives显示文摘 | Maehacek Oldrich Eck Gary R Clark Ross P | 1992 | Int Annu Conf ICT1992，，23： | 1 |
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