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| 1 | Multiparametric analysis of colorectal cancer immune responses显示文摘Colorectal cancer(CRC) is a heterogeneous disease, with a diverse and plastic immune cell infiltrate. These immune cells play an important role in regulating tumour growth-progression or elimination. Some populations of cells have a strong correlation with disease-free survival, making them useful prognostic markers. In particular, the infiltrate of CD3^+ and CD8^+ T cells into CRC tumours has been validated worldwide as a valuable indicator of patient prognosis. However, the heterogeneity of the immune response, both between patients with tumours of different molecular subtypes, and within the tumour itself, necessitates the use of multiparametric analysis in the investigation of tumour-specific immune responses. This review will outline the multiparametric analysis techniques that have been developed and applied to studying the role of immune cells in the tumour, with a focus on colorectal cancer. Because much of the data in this disease relates to T cell subsets and heterogeneity, we have used T cell populations as examples throughout. Flow and mass cytometry give a detailed representation of the cells within the tumour in a single-cell suspension on a per-cell basis. Imaging technologies, such as imaging mass cytometry, are used to investigate increasing numbers of markers whilst retaining the spatial and structural information of the tumour section and the infiltrating immune cells. Together, the analyses of multiple immune parameters can provide valuable information to guide clinical decision-making in CRC. | Julia KH Leman Sarah K Sandford Janet L Rhodes Roslyn A Kemp | 2018 | World Journal of Gastroenterology2018，24，27： | 12 |
| 2 | Tertiary lymphoid structures in cancer – considerations for patient prognosis显示文摘Tertiary lymphoid structures(TLS)are ectopic lymphoid formations that form within nonlymphoid tissue.They share structural and functional characteristics with secondary lymphoid structures such as lymph nodes and can contain B-cell follicles and germinal centers surrounded by a T-cell region.TLS have been described in several types of cancers and are usually associated with positive patient outcomes.However,TLS differ vastly in cellular composition and location within tissue types.In this review,we discuss factors confounding the interpretation of the evidence for a prognostic role for TLS in cancer and frame these factors in the context of translation to regular clinical use. | Luis Munoz-Erazo Janet L.Rhodes Valentine C.Marion Roslyn A.Kemp | 2020 | Cellular & Molecular Immunology2020，17，6： | 11 |
| 3 | Incisional hernia显示文摘 | Santora TA Roslyn JJ | 1993 | Surg Clin North Am1993，73，3： | 1 |
| 4 | Introduction to the Special Issue on New Perspectives on Youth Development and Social Identity in the 21st Century显示文摘 | Jean Anyon Ratna Ghosh Roslyn Arlin | 2007 | The Teachers College Record2007，109，2： | 1 |
| 5 | Comparison of the BD Affirm VPIII Test to Primary Care and Clinical Laboratory Methods for the Diagnosis of Bacterial Vaginosis and Yeast Vaginitis显示文摘 | Arthur EC David B Roslyn VM | 2011 | Infect Dis Clin Pract2011，19，4： | 1 |
| 6 | INCITE:A randomised trial comparing constraint induced movement therapy and bimanual training in children with congenital hemiplegia 显示文摘 | Roslyn B Leanne S Jenny Z | 2010 | BMC Neurology2010，10，4： | 1 |
| 7 | Opencholecys tectomy contemprorary analgsis of 42474 patients显示文摘 | Roslyn JJ Binns GS Hughes EX | 1993 | Ann Surg1993，218，6： | 1 |
| 8 | Charaterization and comparison of Pasteurella multocida strains associated with porcine pneumonia and atrophic rhinitis显示文摘 | Robert L D Roslyn M Baillie S | 2003 | Medical Microbiol2003，52，： | 1 |
| 9 | Surgical issues for the elderly patient with hepatobiliary disease 显示文摘 | Kahng KU Roslyn JJ | 1994 | Surg Clin North Am1994，74，2： | 1 |
| 10 | Intranasal vaccination with ISCOMATRIX adjuvanted influenza vaccine显示文摘 | Alan C Rodney H Roslyn D | 2003 | Vaccine2003，21，2： | 1 |
| 11 | Isolation of rat aortic endothelial cells by primary explant techniques and their phenotypic modulation by defined substrata显示文摘 | Roslyn WO | 1987 | Lab Invest1987，57，1： | 1 |
| 12 | Incisional hernia显示文摘 | Santora TA Roslyn JJ | 1993 | Surg Clin North Am1993，73，3： | 1 |
| 13 | Open cholecystectomy:A contemporary analysis of 42474 patients显示文摘 | Roslyn JJ Binns GS Hughes EFX | 1993 | Ann Surg1993，218，2： | 1 |
| 14 | Open cholecysttomy:A contemporary analysis of 42474 patients 显示文摘 | Binns GS Hughes EF | 1993 | Ann Surg1993，218，： | 1 |
| 15 | Entrepreneorship,Chaos and the Tourism Area Lifecycle显示文摘 | Roslyn Russell Bill Faulkner | 2004 | Annals of Tourism Research2004，31，3： | 1 |
| 16 | Open cholecystectomy:acontemporary analysis of 42474 patients显示文摘 | Roslyn J J Binns GS Hughes EF | 1993 | Ann Surg1993，218，2： | 1 |
| 17 | An in vitro cell culture system to study the influence of external pneumatic compression on endothelial function显示文摘 | Guohao Dai a Olga Tsukurov Roslyn Orkia | 2000 | Jouinal of Vascular Surgery2000，32，5： | 1 |
| 18 | Systemic Inflammatory Response Predicts Prognosis in Patients with Advanced-Stage Colorectal Cancer显示文摘 | Rohini Sharma Manuela Zucknick Roslyn London Marina Kacevska Christopher Liddle Stephen J. Clarke | 2008 | Clinical Colorectal Cancer2008，，5： | 1 |
| 19 | changing patterns in diagnosis and management of bile duct cancer显示文摘 | Tompkims R K Saunders K Y Roslyn J J | 1990 | AnnSurg1990，211，5： | 1 |
| 20 | Visceral adiposity in gastrointestinal and hepatic carcinogenesis显示文摘 | Roslyn Vongsuvanh Jacob George Liang Qiao David van der Poorten | 2012 | Cancer Letters2012，，： | 1 |
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