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| 1 | Multiphase computed tomography radiomics of pancreatic intraductal papillary mucinous neoplasms to predict malignancy显示文摘BACKGROUND Intraductal papillary mucinous neoplasms(IPMNs)are non-invasive pancreatic precursor lesions that can potentially develop into invasive pancreatic ductal adenocarcinoma.Currently,the International Consensus Guidelines(ICG)for IPMNs provides the basis for evaluating suspected IPMNs on computed tomography(CT)imaging.Despite using the ICG,it remains challenging to accurately predict whether IPMNs harbor high grade or invasive disease which would warrant surgical resection.A supplementary quantitative radiological tool,radiomics,may improve diagnostic accuracy of radiological evaluation of IPMNs.We hypothesized that using CT whole lesion radiomics features in conjunction with the ICG could improve the diagnostic accuracy of predicting IPMN histology.AIM To evaluate whole lesion CT radiomic analysis of IPMNs for predicting malignant histology compared to International Consensus Guidelines.METHODS Fifty-one subjects who had pancreatic surgical resection at our institution with histology demonstrating IPMN and available preoperative CT imaging were included in this retrospective cohort.Whole lesion semi-automated segmentation was performed on each preoperative CT using Healthmyne software(Healthmyne,Madison,WI).Thirty-nine relevant radiomic features were extracted from each lesion on each available contrast phase.Univariate analysis of the 39 radiomics features was performed for each contrast phase and values were compared between malignant and benign IPMN groups using logistic regression.Conventional quantitative and qualitative CT measurements were also compared between groups,viaχ2(categorical)and Mann Whitney U(continuous)variables.RESULTS Twenty-nine subjects(15 males,age 71±9 years)with high grade or invasive tumor histology comprised the'malignant'cohort,while 22 subjects(11 males,age 70±7 years)with low grade tumor histology were included in the'benign'cohort.Radiomic analysis showed 18/39 precontrast,19/39 arterial phase,and 21/39 venous phase features differentiated malignant from benign IPMNs(P<0.05).Multivariate analysis including only ICG criteria yielded two significant variables:thickened and enhancing cyst wall and enhancing mural nodule<5 mm with an AUC(95%CI)of 0.817(0.709-0.926).Multivariable post contrast radiomics achieved an AUC(95%CI)of 0.87(0.767-0.974)for a model including arterial phase radiomics features and 0.834(0.716-0.953)for a model including venous phase radiomics features.Combined multivariable model including conventional variables and arterial phase radiomics features achieved an AUC(95%CI)of 0.93(0.85-1.0)with a 5-fold cross validation AUC of 0.90.CONCLUSION Multi-phase CT radiomics evaluation could play a role in improving predictive capability in diagnosing malignancy in IPMNs.Future larger studies may help determine the clinical significance of our findings. | Stuart L Polk Jung W Choi Melissa J McGettigan Trevor Rose Abraham Ahmed Jongphil Kim Kun Jiang Yoganand Balagurunathan Jin Qi Paola T Farah Alisha Rathi Jennifer B Permuth Daniel Jeong | 2020 | World Journal of Gastroenterology2020，26，24： | 5 |
| 2 | Redicting Business Failure: A Macroeconomic Perspective 显示文摘 | Rose Peter S Andrews Wesley T Giroux Gary A P | 1982 | Journal of Accounting Auditing and Finance1982，，1： | 1 |
| 3 | Reflected Blast Wave Resultants Behind Cantilever Walls:A New Prediction Technique 显示文摘 | CHAPMAN T C ROSE T A SMITHS P D | 1995 | International Journal of Impact Engineering1995，16，3： | 1 |
| 4 | The angle stable locking-proximal-humerus-plate (LPHP) for proximal humeral fractures using a small anterior lateral deltoid splitting approach technique and first results显示文摘 | Lill H Hepp P Rose T | 2004 | Zentralbl Chir2004，129，1： | 1 |
| 5 | Total bilirubin is a useful predictor of persisting common bile duct stone in gallstone pancreatitis 显示文摘 | Chan T Yaghoubian A Rosing D | 2008 | Am Surg2008，74，10： | 1 |
| 6 | Ultrasonic guided wave and acoustic impact methods for pipe fouling detection显示文摘 | HAY T R ROSE J L | 2003 | Journal of Engineering2003，56，5： | 1 |
| 7 | Facade failure effects on blast propagation along city streets显示文摘 | SMITH P D ROSE T A KRAHE S L | 2003 | Structures and Buildings2003，156，4： | 1 |
| 8 | The angle stable locking proximal humerus plate(LPHP) for proximal humeral fractures using a small anterior lateral deltoid splitting approach technique and first results显示文摘 | Hill H Hepp P Rose T | 2004 | Zentralbl Chir2004，129，1： | 1 |
| 9 | The Locking-proximal- humerus-plate (LPHP) for proximal humeral fractures using a small anterlor-lateral-del approach-techniq toid-splitting- ue and first results 显示文摘 | Lill H Hepp angle stable P Rose T | 2004 | Zentralbl CMr2004，129，： | 1 |
| 10 | A synthetic time- reversal imaging method for structural health monito- ring显示文摘 | Wang C H Rose J T Chang F K | 2004 | Smart Materials and Structures2004，13，2： | 1 |
| 11 | In vitro differentiation of a cloned bovine mammary epithelial cell显示文摘 | ROSE B T ASO H YONEKURA S | 2002 | Journal of Dairy Research2002，69，3： | 1 |
| 12 | Soluble and transmembrane isoforms of novel interleukin-17 receptor-like protein by RNA splicing and expression in prostate cancer显示文摘 | Haudenschild D Moseley T Rose L | 2002 | J Biol Chem2002，277，6： | 1 |
| 13 | Brief paradoxical sleep deprivation impairs reference, but not working memory in the radial arm maze task显示文摘 | Smith C T Conway J M Rose G M | 1998 | Neurobiol Learn Mem1998，69，2： | 1 |
| 14 | Fouling detection in the food industry using ultrasonic guided waves显示文摘 | HAY T R ROSE J L | 2003 | Food Control2003，14，7： | 1 |
| 15 | Diode-pumped 1- W continuous-wave Er YAG 3-1am laser显示文摘 | Chen D W Fincher C L Rose T S | 1999 | Optics Let- ters1999，24，6： | 1 |
| 16 | Patients' prespectives on ECT:systematic review显示文摘 | Rose D Wykes T Leese M | | 0，，21： | 1 |
| 17 | Interleukin-17 family and IL-17 receptors显示文摘 | MOSELEY T A HAUDENSCHILD D R ROSE L | 2003 | Cytokine Growth Factor Rev2003，14，2： | 1 |
| 18 | Guided wave dis- persion curves for a bar with an arbitrary cross-section, a rod and rail example 显示文摘 | HAYASHI T SONG W J ROSE J L | 2003 | Ultrasonics2003，41，3： | 1 |
| 19 | In vitro differentiation of a cloned bovine mammary epithelial cell 显示文摘 | Rose M T Aso H Yonekura S | 2002 | Journal of Dairy Research2002，69，： | 1 |
| 20 | Consensusdegenerate hybrid oligonucleotide primers for amplification of distantly related sequences显示文摘 | Rose T M Schultz E R Henikoff J G | 1998 | Nucleic Acids Res1998，26，7： | 1 |
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