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| 1 | Open-porous magnesium-based scaffolds withstand in vitro corrosion under cyclic loading:A mechanistic study显示文摘The successful application of magnesium(Mg)alloys as biodegradable bone substitutes for critical-sized defects may be comprised by their high degradation rate resulting in a loss of mechanical integrity.This study investigates the degradation pattern of an open-porous fluoride-coated Mg-based scaffold immersed in circulating Hanks’Balanced Salt Solution(HBSS)with and without in situ cyclic compression(30 N/1 Hz).The changes in morphological and mechanical properties have been studied by combining in situ high-resolution X-ray computed tomography mechanics and digital volume correlation.Although in situ cyclic compression induced acceleration of the corrosion rate,probably due to local disruption of the coating layer where fatigue microcracks were formed,no critical failures in the overall scaffold were observed,indicating that the mechanical integrity of the Mg scaffolds was preserved.Structural changes,due to the accumulation of corrosion debris between the scaffold fibres,resulted in a significant increase(p<0.05)in the material volume fraction from 0.52±0.07 to 0.47±0.03 after 14 days of corrosion.However,despite an increase in fibre material loss,the accumulated corrosion products appear to have led to an increase in Young’s modulus after 14 days as well as lower third principal strain(εp3)accumulation(-91000±6361μεand-60093±2414μεafter 2 and 14 days,respectively).Therefore,this innovative Mg scaffold design and composition provide a bone replacement,capable of sustaining mechanical loads in situ during the postoperative phase allowing new bone formation to be initially supported as the scaffold resorbs. | Roxane Bonithon Colin Lupton Marta Roldo Joseph Nicholas Dunlop Gordon William Blunn Frank Witte Gianluca Tozzi | 2023 | Bioactive Materials2023，，1： | 2 |
| 2 | MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior显示文摘 | Roldo C Missiaglia E Hagan JP | | J Clin Oncol0，24，29： | 1 |
| 3 | MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior显示文摘 | Roldo C Missiaglia E Hagan JP | | 0，，： | 1 |
| 4 | MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior 显示文摘 | Roldo C Missiaglia E Hagan JP | 2006 | J Clin Oncol2006，24，29： | 1 |
| 5 | MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior显示文摘 | Roldo C Missiaglia E Hagan JP | 2006 | J Clin Oncol2006，24，29： | 1 |
| 6 | CDX 22 homeobox gene product exp ression in neuroendocrine tumors: its role as a marker of intestinal neuroendoerine tumors显示文摘 | Barbareschi M Roldo C Zamboni G | 2004 | Am J Surg Pathol2004，28，9： | 1 |
| 7 | MicroRNA ex- pression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior显示文摘 | Roldo C Missiaglia E Hagan JP | 2006 | J Clin 0ncol2006，24，29： | 1 |
| 8 | MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior显示文摘 | Roldo C Missiaglia E Hagan JP | 2006 | J Clin Oncol2006，24，29： | 1 |
| 9 | MicroRNA expres- sion abnormalities in pancreatic endocrine z, nd acinar tumors are associated with distinctive pathologic features and clinical behavior 显示文摘 | Roldo C Missiaglia E Hagan JP | 2006 | J Clin Oncol2006，24，： | 1 |
| 10 | Knockout mice reveal a tumor suppressor function for testin显示文摘 | Drusco A Zanesi N Roldo C | 2005 | Proc Natl Acad Sci USA2005，102，10： | 1 |
| 11 | MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior显示文摘 | Roldo C Missiaglia E Hagan JP | | 0，，29： | 1 |
| 12 | Activity of a hydroxybibenzyl bryophyte constituent against leish-mania spp and trypanosoma cruzi:in silico,in vitro and in vivo activity studies显示文摘 | ROLDOS V NAKAYAMA H ROLON M | 2008 | Bioorg Med Chem2008，43，9： | 1 |
| 13 | MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior显示文摘 | Roldo C Missiaglia E Hagan JP | 2006 | J Clin Oncol2006，24，29： | 1 |
| 14 | MicroRNA expression ab-normalities in pancreatic endocrine and acinar tumor sareassociated with distinctive pathologic features and clinic albehavior显示文摘 | Roldo C Missiaglia E HaganJP | 2006 | J Clin Oncol2006，24，29： | 1 |
| 15 | Large-scale production and purification of VLP-based vaccines显示文摘 | Vicente T Roldo A Peixoto C | 2011 | J Invertebr Pathol2011，，： | 1 |
| 16 | MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior显示文摘 | Roldo C Missiaglia E Hagan JP | 2006 | J Clin Oncol2006，24，29： | 1 |
| 17 | MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior显示文摘 | Roldo C Missiaglia E Hagan JP | | 0，，： | 1 |
| 18 | Mucoadhesive thiolated chitosans as platforms for oral controlled drug delivery:synthesis and in vitro evaluation显示文摘 | ROLDO M HORNOFM CALICETIP | 2004 | Eur J Pharm Biopharm2004，57，1： | 1 |
| 19 | MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior 显示文摘 | Roldo C Missiaglia E Hagan JP | 2006 | J Clin Oncol2006，24，29： | 1 |
| 20 | MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associ- ated with distinctive pathologic features and clinical behavior显示文摘 | Roldo C Missiaglia E Hagan JP | 2006 | J Chn Onco12006，24，29： | 1 |
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