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| 1 | 帕博利珠单抗治疗伴脑转移NSCLC患者的一项非随机、开放Ⅱ期试验的长期随访结果和生物标志物分析显示文摘背景与目的我们开展了一项帕博利珠单抗用于伴未治疗脑转移的非小细胞肺癌(non-small cell lung cancer,NSCLC)或黑色素瘤患者的疗效和安全性的II期试验,旨在评估程序性死亡受体1(programmed cell death 1,PD-1)抑制剂在中枢神经系统(central nervous system,CNS)中的疗效。中期结果已发表,现报道对NSCLC队列的更新分析结果。方法这是一项开放性、单中心、II期试验。纳入标准:年龄≥18岁,诊断为晚期NSCLC并伴有≥1个5 mm-20 mm脑转移病灶,既往从未治疗或之前放疗后进展,无神经系统症状,不需要激素治疗且美国东部肿瘤协作组(Eastern Cooperative Oncology Group,ECOG)<2分。患者每2周接受一次帕博利珠单抗(10 mg/kg)治疗。队列1为程序性死亡配体1(programmed cell death ligand 1,PD-L1)≥1%的患者,队列2为PD-L1<1%或未评估的患者。主要终点是脑转移患者缓解比例。所有经治患者均纳入疗效与安全性终点的分析。该研究已结束入组,并于Clinicaltrials.gov登记注册,注册号为NCT02085070。结果2014年3月31日-2018年5月21日,共42例患者接受治疗。中位随访时间为8.3个月(IQR:4.5个月-26.2个月)。队列1的37例患者中11例有脑转移缓解[29.7%(95%CI:15.9%-47.0%)]。队列2未观察到缓解。治疗相关的3级-4级不良事件(adverse events,AEs)包括2例肺炎、1例全身症状、1例结肠炎、1例肾上腺皮质功能不全、1例高血糖症和1例低钾血症。6例(14%)患者发生了治疗相关的严重不良事件,包括肺炎、急性肾损伤、低钾血症和肾上腺皮质功能不全。没有观察到治疗相关死亡病例。结论帕博利珠单抗治疗PD-L1≥1%的NSCLC伴脑转移患者有效,且对所有纳入的未经治疗的脑转移患者安全。需要进一步探索免疫治疗用于NSCLC合并CNS转移。 | Sarah B GOLDBERG Kurt A SCHALPER Scott N GETTINGER Amit MAHAJAN Roy S HERBST Anne C CHANG Rogerio LILENBAUM Frederick H WILSON Sacit Bulent OMAY James B YU Lucia JILAVEANU Thuy TRAN Kira PAVLIK Elin ROWEN Heather GERRSH Annette KOMLO Richa GUPTA Hailey WYATT Matthew RIBEIRO Yuval KLUGER Geyu ZHOU Wei WEI Veronica L CHANG Harriet M KLUGER 董晓荣(翻译/校对) | 2021 | 中国肺癌杂志2021，24，9： | 34 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Lead Recovery from a Typical Brazilian Sludge of Exhausted Lead-acid Batteries Using an Electro-hydrometallurgical Process显示文摘 | Luiz C Ferracin Abel E Chacon-Sanhueza Rogerio A | 2002 | Hydrometallurgy2002，65，42： | 1 |
| 4 | Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma显示文摘 | Rogerio A P Kanashiro A Fontanari C | 2007 | Inflammation Res2007，56，10： | 1 |
| 5 | Impro- ving power system dynamic behavior through doubly fed induction machines controlled by static converter using fuzzy control 显示文摘 | G De Almeida Rogerio J A Pecas Lopes J A L Barreiros | 2004 | IEEE Transaction on Power System November2004，19，4： | 1 |
| 6 | Antiinflammatory effect of Queuercetin-loaded microemulsion in the airways allergic inflammatory model in mice显示文摘 | Rogerio A P Dora C L Andrade E L | 2010 | Pharmacological Research2010，61，4： | 1 |
| 7 | Corn posite materials in flexible multibody systems 显示文摘 | MARIA A N JORGE A C ROGERIO P L | 2006 | Computer Methods in Applied Mechanics and Engineering2006，195，： | 1 |
| 8 | Effect of impeller type and mechanical agitation on the mass transfer and power consumption aspects of ASBR operation treating synthetic wastewater显示文摘 | Michelan Rogerio Zimmer Thiago R Rodrigues Jose A D | 2009 | Journal of Environmental Management2009，90，3： | 1 |
| 9 | Quality characteristics of high pressure-induced hake (Merluccius capensis)protein gels with and without MTGase显示文摘 | CARLOS L C ROGERIO 0 M JORGE A S | 2010 | Journal of Aquatic Food Product Technology2010，19，34： | 1 |
| 10 | Correlation of bacterial coinfection versus matrix metalloproteinase 9 and tissue inhibitor of metalloproteinase 1 expression in aortic aneurysm and athero- sclerosis显示文摘 | Rogerio A Sambiase NV Palomino SA | 2013 | Ann Vasc Surg2013，27，7： | 1 |
| 11 | Induced sputum and peripheral blood cell profile in chronic obstructive pulmonary disease显示文摘 | ROGERIO R CL(A)UDIA H C HEITOR-SIFFERT P S | 2007 | J Bras Pneumol2007，33，5： | 1 |
| 12 | Performance of a polyaniline(DMcT)/carbon fiber composite as cathode for rechargeable lithium batteries显示文摘 | SHEILA C CANOBRE ROGERIO A DAVOGLIO SONIA R BIAGGIO | 2006 | J Power Sour2006，154，1： | 1 |
| 13 | Participation of doubly fed induction wind generators in system frequency regulation 显示文摘 | Rogerio G Pecas J A | 2007 | IEEE Transactions on Power Systems2007，22，3： | 1 |
| 14 | Participation of doubly fed induction wind generators in system frequency regulation显示文摘 | De Almeida Rogerio G Pecas Lopes J A | 2007 | IEEE Transactions on Power Systems2007，22，3： | 1 |
| 15 | Anti-inflammatory effect of quereetin-loaded microemulsion in the airways allergic inflammatory model in mice显示文摘 | Alexandre P Rogerio A Cristiana L | 2010 | Pharmacol Res2010，61，： | 1 |
| 16 | What are the key features of importanceinpolycystic ovary syndrome?显示文摘 | Rogerio A L | 2003 | Fertil Steril2003，80，2： | 1 |
| 17 | Intravitreal bevacizumab (Avastin) for persistent new vessels in diabetic retinopathy (IBEPE STUDY) 显示文摘 | Rodrigo J Rogerio A Daniela C | 2006 | Retina2006，26，6： | 1 |
| 18 | Domain size effects in molecular dynamics simulation of phonon transport in silicon 显示文摘 | ROGERIO F S MARCIO A R C A JANDIR M H | 2003 | Appl Phys Lett2003，89，17： | 1 |
| 19 | Bax and Bcl-2 expression and TUNEL labeling in lumbar enlargement of neonatal rats after sciatic axotomy and melatonin treatment 显示文摘 | Rogerio F Jr H J Vieira A S | 2006 | Brain Res2006，1112，： | 1 |
| 20 | Effect of impeller type and mechanical agitation on the mass transfer and power consumption aspects of ASBR operation treating synthetic waste water显示文摘 | Rogerio M Thiago R Z Jose A D | 2009 | Journal of Environmental Management2009，90，5： | 1 |
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