|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Molecular mecha- nisms underlying emotional learning and memory in the lat- eral amygdala显示文摘 | Rodrigues SM Schafe GE LeDoux JE | 2004 | Neuron2004，44，1： | 1 |
| 2 | Poststroke dementia: Clinical features and risk factors显示文摘 | Barb R Martinez ES Rodrigue GE | 2000 | Stroke2000，31，7： | 1 |
| 3 | Poststmke dementia: Clinical features and risk factors显示文摘 | Barb R Martinez ES Rodrigue GE | 2000 | Stroke2000，31，： | 1 |
| 4 | A common human TLR1 pol- ymorphism regulates the innate immune response to lipopep- tides显示文摘 | Hawn TR Misch EA Dunstan SJ Thwaites GE Lan NT Quy HT Chau TT Rodrigues S Naehman A Janer M Hien TT Farrar JJ Aderem A | 2007 | Eur J Immunol2007，37，8： | 1 |
| 5 | Molecular mechanisms underlying review emotional learning and memory in the lateral amygdala显示文摘 | Rodrigues SM Schafe GE LeDoux JE | | 0，，01： | 1 |
| 6 | Intra - amygdala blockade of the NR2B subunit of the NMDA receptor disrupts the acquisition but not the expression of fear conditioning显示文摘 | RODRIGUES SM SCHAFE GE LEDOUX JE | | 0，，17： | 1 |
| 7 | Post-stroke dementia: clinical features and risk factos显示文摘 | Barb R Martinez ES Rodrigue GE | 2000 | Stroke2000，31，7： | 1 |
| 8 | Intra-amygdala blockade of the NR2B subunit of the NMDA receptor disrupts the acquisition but not the expression of fear conditioning显示文摘 | Rodrigues SM Schafe GE Ledoux JE | 2001 | J Neurosci2001，21，17： | 1 |
| 9 | Poststroke dementia: clinical features and risk factors显示文摘 | Barb R Martinez ES Rodrigue GE | 2000 | Stroke2000，31，7： | 1 |
| 10 | Loss of LAT1 sex-dependently delays recovery after caerulein-induced acute pancreatitis显示文摘BACKGROUND The expression of amino acid transporters is known to vary during acute pancreatitis(AP)except for LAT1(slc7a5),the expression of which remains stable.LAT1 supports cell growth by importing leucine and thereby stimulates mammalian target of rapamycin(mTOR)activity,a phenomenon often observed in cancer cells.The mechanisms by which LAT1 influences physiological and pathophysiological processes and affects disease progression in the pancreas are not yet known.AIM To evaluate the role of LAT1 in the development of and recovery from AP.METHODS AP was induced with caerulein(cae)injections in female and male mice expressing LAT1 or after its knockout(LAT1 Cre/LoxP).The development of the initial AP injury and its recovery were followed for seven days after cae injections by daily measuring body weight,assessing microscopical tissue architecture,mRNA and protein expression,protein synthesis,and enzyme activity levels,as well as by testing the recruitment of immune cells by FACS and ELISA.RESULTS The initial injury,evaluated by measurements of plasma amylase,lipase,and trypsin activity,as well as the gene expression of dedifferentiation markers,did not differ between the groups.However,early metabolic adaptations that support regeneration at later stages were blunted in LAT1 knockout mice.Especially in females,we observed less mTOR reactivation and dysfunctional autophagy.The later regeneration phase was clearly delayed in female LAT1 knockout mice,which did not regain normal expression of the pancreas-specific differentiation markers recombining binding protein suppressor of hairless-like protein(rbpjl)and basic helixloop-helix family member A15(mist1).Amylase mRNA and protein levels remained lower,and,strikingly,female LAT1 knockout mice presented signs of fibrosis lasting until day seven.In contrast,pancreas morphology had returned to normal in wild-type littermates.CONCLUSION LAT1 supports the regeneration of acinar cells after AP.Female mice lacking LAT1 exhibited more pronounced alterations than male mice,indicating a sexual dimorphism of amino acid metabolism. | Cristina M Hagen Eva Roth Theresia Reding Graf François Verrey Rolf Graf Anurag Gupta Giovanni Pellegrini Nadège Poncet Simone Mafalda Rodrigues Camargo | 2022 | World Journal of Gastroenterology2022，28，10： | 0 |
| 11 | Interaction between Equatorial Plasma Bubbles and a Medium-Scale Traveling Ionospheric Disturbance,observed by OI 630 nm airglow imaging at Bom Jesus de Lapa,Brazil显示文摘OI 630.0 nm airglow observations,from a new observatory at Bom Jesus de Lapa,were used to study the interaction between EPBs(Equatorial Plasma Bubbles)and the MSTID(Medium-Scale Traveling Ionospheric Disturbance)over the Northeast region in Brazil.On the night of September 16 to 17,2020,an EPB was observed propagating eastward,in an apparent fossil stage,until it interacted with a dark band electrified MSTID(e MSTID).After the interaction,four EPBs merged,followed by an abrupt southward development and bifurcations.Analysis of the data suggests that an eastward polarization electric field,induced by the dark band e MSTID,forced the EPB into an upward drift,growing latitudinally along the magnetic field lines and then bifurcating. | Cristiano Max Wrasse Cosme Alexandre Oliveira Barros Figueiredo Diego Barros Hisao Takahashi Alexander JoséCarrasco Luiz Fillip Rodrigues Vital Láysa Cristina Araujo Resende Fábio Egito Geângelo de Matos Rosa Antonio Hélder Rodrigues Sampaio | 2021 | Earth and Planetary Physics2021，5，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员