|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 肌萎缩性侧索硬化蛋白激活小胶质细胞NLRP3炎性小体显示文摘小胶质细胞NLRP3炎性小体激活正在成为神经退行性变过程中神经炎症的关键因素。诸如β-淀粉样蛋白和α-突触核蛋白之类的致病性蛋白质聚集体触发小胶质NLRP3激活,从而导致半胱天冬酶-1激活和IL-1β的分泌。在小鼠肌萎缩性侧索硬化症(ALS)的SOD1G93A模型中,半胱天冬酶-1和IL-1β均促进疾病进展,提示小胶质NLRP3在该进程中发挥作用。然而先前的研究表明,SOD1G93A小鼠小胶质细胞不表达NLRP3,SOD1G93A蛋白在小胶质细胞中产生独立于NLRP3的IL-1β。本研究论证了使用Nlrp3-GFP基因敲入小鼠,在SOD1G93A小鼠中小胶质细胞表达NLRP3。本研究显示聚集和可溶性SOD1G93A均可激活小鼠原代小胶质细胞中的炎性小体,导致半胱天冬酶-1和IL-1β裂解,ASC斑点形成以及呈剂量和时间依赖性的IL-1β分泌。重要的是,SOD1G93A无法从缺乏Nlrp3的小胶质细胞或者用特异性NLRP3抑制剂MCC950预处理的小胶质细胞中诱导IL-1β分泌,从而证实NLRP3是介导SOD1诱导的小胶质细胞IL-1β分泌的关键炎症小体复合物。在TDP-43Q331K ALS小鼠模型中也观察到小胶质NLRP3上调,TDP-43野生型和突变蛋白亦可以NLRP3依赖性的方式激活小胶质炎性小体。从机制上讲,本研究确定了活性氧簇和ATP的生成是SOD1G93A介导的NLRP3激活所需的关键事件。总之,本研究的数据表明ALS小胶质细胞表达NLRP3,而病理ALS蛋白激活小胶质NLRP3炎性小体。因此,NLRP3抑制可能是阻止小胶质细胞神经炎症和ALS疾病进展的潜在治疗方法。 | Vandana Deora John D Lee Eduardo AAlbornoz Luke McAlary Cyril J Jagaraj Avril A B Robertson Julie D Atkin Matthew A Cooper Kate Schroder Justin J Yerbury Richard Gordon Trent MWoodruff 杜一星(编译) | 2020 | 神经损伤与功能重建2020，15，9： | 13 |
| 2 | Optimization of Thermoelectric Green Tape Characteristics Made by the Tape Casting Method显示文摘 | Salam L A Matthews R D Robertson H | 2000 | Mater Chem Phys2000，62，： | 1 |
| 3 | Lidar-measured winds from space: a key component for weather and climate prediction 显示文摘 | BAKER W E EMMITT G D ROBERTSON F | 1995 | Bulletin of the American Meteorological Society1995，76，6： | 1 |
| 4 | Precision determination of lattice parameters and coefficients of thermal expansion of BiFeO3显示文摘 | Bucci J D Robertson B K James W J | 1972 | J Appl Cryst1972，5，： | 1 |
| 5 | Survival following hepatic resection of colorectal cancer metastases: a national experience 显示文摘 | Robertson D J Stukel TA Gottlieb D J | 2009 | Cancer2009，115，4： | 1 |
| 6 | Do coral-reef fish faunas have a distinctive taxonomic structure?显示文摘 | Robertson D R | 1998 | Coral Reefs1998，17，1： | 1 |
| 7 | Phosphate plume persistence at two decommissioned septic system sites显示文摘 | Robertson W D Harman J | 1999 | Ground Water1999，37，22： | 1 |
| 8 | Age is prognostic variable in cervical squamous cell carcinoma 显示文摘 | Robertson D Fedorkow DM Stwart GC | 1993 | Eur J Gynecol Oncol1993，44，： | 1 |
| 9 | Molecuar weight forms of inhibin A,inkibin B and Pro-aC in maternal serum,amniotic fluid and placental extracts of normal and Down'syndrome Pregnancies显示文摘 | ThirunavukarasuPP Robertson D M Dawson J | 2002 | Prenat Diagn2002，22，12： | 1 |
| 10 | Three-dimensional analysis of the proximal part of the humerus:Relevance to arthroplasty显示文摘 | Robertson D Yuan J Bigliani L | 2000 | J Bone Joint Surg Am2000，82，11： | 1 |
| 11 | Clonal analysis and virulence of Australian isolates of Streptococcus suis type 2显示文摘 | Mwaniki C G Robertson L D Trott D J | 1994 | Epidemiol Infect1994，113，： | 1 |
| 12 | Design and responses of Butterworth and critically damped digital filters显示文摘 | ROBERTSON D G E DOWLING J J | 2003 | Journal of Electromyography and Kinesiology2003，，13： | 1 |
| 13 | Isothermal hot deformation behavior of metasTable 13 titanium alloy Ti-IOV-2Fe-3A1 显示文摘 | Robertson D G McShane H B | 1997 | Marer Sci Technol1997，13，： | 1 |
| 14 | Pathology of aural abscesses in free - living Eastern box turtles ( Terrapene carolina carolina) 显示文摘 | Brown J D Richards J M Robertson J | 2004 | Journal of Wildlife Diseases2004，40，4： | 1 |
| 15 | Functional ex- pression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells显示文摘 | Chambers I Colby D Robertson M | 2003 | Ce112003，113，5： | 1 |
| 16 | Additive partitioning of di- versity across hierarchical spatial scales in a forested landscape 显示文摘 | Chandy S Gibson D J Robertson P A | 2006 | Journal of Applied Ecology2006，43，4： | 1 |
| 17 | Measurement of the rotational quency shift imparted to a rotating light beam possessing orbital angular显示文摘 | Courtial J Robertson D A Dholakia K | 1998 | Phys Rev Lett1998，81，15： | 1 |
| 18 | Early interventions involving parents to improve neurodevelopmental outcomes of premature infants : a meta-analysis显示文摘 | Bassler D Robertson CMT Kirpalani H | 2009 | J Perinatol2009，29，5： | 1 |
| 19 | A low pressure micromachined flow modulator显示文摘 | ROBERTSON J K WISE K D | 1998 | Sensors and Actuators A:Physical1998，97，12： | 1 |
| 20 | Effects of epidermal growth factor on hair growth in the mouse显示文摘 | Moore G P M Panaretto B A Robertson D M | 1981 | J Endocrinol1981，88，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员