|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Increased incidence of early de novo cancer in liver graft recipients treated with cyclosporine: An association with C显示文摘 | Angela S. W. Tjon Jerome Sint Nicolaas Jaap Kwekkeboom Robert A. de Man Geert Kazemier Hugo W. Tilanus Bettina E. Hansen Luc J. W. van der Laan Thanyalak Tha‐In Herold J. Metselaar | 2010 | Liver Transpl2010，，7： | 2 |
| 2 | Targeting the Wnt Signaling Pathway in Liver Fibrosis for Drug Options:An Update显示文摘morbidity and mortality for healthcare systems worldwide.It imparts an enormous economic burden to societies,making continuous research and informational updates about its pathogenesis and treatment crucial.This review′s focus is on the current knowledge about the Wnt signaling path-way,serving as an important pathway in liver fibrosis development and activation of hepatic stellate cells(HSCs).Two types of Wnt pathways are distinguished,namely the ß-catenin-dependent canonical and non-canonical Ca^(2+) or planar cell polarity(PCP)-dependent pathway.The dynamic balance of physiologically healthy liver and hepatocytes is disturbed by repeated liver injuries.Activation of theß-catenin Wnt pathway prevents the regeneration of hepatocytes by the replacement of extracellular matrix(ECM),leading to the appearance of scar tissue and the formation of regenerated nodular hepatocytes,lacking the original function of healthy hepatocytes.Therefore,liver function is reduced due to the severely advanced disease.Selective inhibition ofß-catenin inhibits inflammatory processes(since chemokines and pro-inflammatory cytokines are produced during Wnt activation),reduces growth of activated HSCs and reduces collagen synthesis and angiogenesis,thereby reducing the progression of liver fibrosis in vivo.While the canonical Wnt pathway is usually inactive in a physiologically healthy liver,it shows activity during cell regeneration or renewal and in certain pathophysiological conditions,such as liver diseases and cancer.Targeted blocking of some of the basic components of the Wnt path-way is a therapeutic approach.These include the frizzled transmembrane receptor(Fz)receptors using the secreted frizzled-related protein family(sFRP),Fz-coreceptors low-density LRP 5/6 through dickkopf-related protein 1(DKK1)or niclosamide,glycogen kinase-3 beta(GSK-3β)using SB-216763,cyclic-AMP response element-binding protein(CBP)using PRI-724 and ICG-001,the lymphoid enhancer binding factor(LEF)/T cell-specific transcription factor(TCF)system as well as Wnt inhibitory factor 1(WIF1)and miR-17-5p using pinostilbene hydrate(PSH).Significant progress has been made in inhibiting Wnt and thus stopping the progression of liver fibrosis by diminishing key components for its action.Comprehending the role of the Wnt signaling pathway in liver fibrosis may lead to discovery of novel targets in liver fibrosis therapeutic strategies’development. | Kristina Duspara Kristina Bojanic Josipa Ivanusic Pejic Lucija Kuna Tea Omanovic Kolaric Vjera Nincevic Robert Smolic Aleksandar Vcev Marija Glasnovic Ines Bilic Curcic Martina Smolic | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 2 |
| 3 | Mutational spectrum of beta-catenin,AXIN1,and AXIN2 in hepatocellular carcinomas and hepatoblastomas显示文摘 | Taniguchi K Roberts LR Aderca IN | 2002 | Oncogene2002，21，31： | 1 |
| 4 | Grubbs显示文摘 | Grey R A The 2000 benjamin franklin medal in chemistry presented to Robert H | 2000 | J Franklin I2000，337，7： | 1 |
| 5 | Effect of styrenic copolymers as compatibilizers显示文摘 | FROUNCHI MASOUD BURFORD ROBERT PAUL State of compatibility in crystalline polypropylene/ABS amorphous terpolymer thermoplastic bends | 1993 | Iranian Journal of Polymer Science and Technology (English Edition)1993，2，2： | 1 |
| 6 | Regulatory T Cells Ameliorate Angiotensin II–Induced Cardiac Damage显示文摘 | Heda Kvakan Markus Kleinewietfeld Fatimunnisa Qadri Joon-Keun Park Robert Fischer Ines Schwarz Hans-Peter Rahn Ralph Plehm Maren Wellner Saban Elitok Petra Gratze Ralf Dechend Friedrich C. Luft Dominik N. Muller | 2009 | Circulation2009，，22： | 1 |
| 7 | International Effects on innovation and Firm Product-diversified Firms 显示文摘 | Michael A H diversification: Performance in of Management Robert E H Hicheon K | 1997 | Academy Journal1997，40，4： | 1 |
| 8 | Mutational spectrum of beta-catenin, AXINI, and AXIN2 in hepatocellular carcino- mas and hepatoblastomas 显示文摘 | Taniguchi K Roberts LR Aderca IN et ol | 2002 | Oncogene2002，21，31： | 1 |
| 9 | Phylogenetic relationships among members of the ascomycetous yeast genera Brettanomyces,Debaryomyces,Dekkem and Kluyveromyces deduced by small-subunit rRNA gene sequences显示文摘 | Cai JP Roberts IN Collins MD | 1996 | Int J Syst Bacteriol1996，46，2： | 1 |
| 10 | Mutational spectrum of beta-catenin , AXIN 1 , and AXIN2 in hepatocellular carcinomas and hepatoblastomas显示文摘 | Taniguchi K Roberts LR Aderca IN | 2002 | Oncogene2002，21，31： | 1 |
| 11 | An integrated mental health clinical rotat-ion显示文摘 | Roberts K T Rob in son K M Stew art C | 2009 | JNurs Educ2009，48，8： | 1 |
| 12 | A hybrid scheduling and control system aiehiteeture for warehouse management 显示文摘 | Kim Byung- In Heragu Sunderesh S Graves Robert | 2003 | IEEE Transaetionson Roboties&Automation2003，12，6： | 1 |
| 13 | Mutational spectrum of beta-catenin,AXIN1,and AXIN2 in hepatocellular carcinomas and hepatoblastomas显示文摘 | Taniguchi K Roberts LR Aderca IN | 2002 | Oncogene2002，21，31： | 1 |
| 14 | Magnetically Responsive Polymeric Microparticles for Oral Delivery of Protein Drugs显示文摘 | Jianjun Cheng Benjamin A. Teply Seok Yoon Jeong Christopher H. Yim Dennis Ho Ines Sherifi Sangyong Jon Omid C. Farokhzad Ali Khademhosseini Robert S. Langer | 2006 | Pharmaceutical Research2006，，3： | 1 |
| 15 | Mutational spectrum of β-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas显示文摘 | Taniguchi K Roberts LR Aderca IN | 2002 | Oncogene2002，21，： | 1 |
| 16 | Spain显示文摘 | DAVID J SANDERSON STEPHEN ROBERTS A Fractal Relationship between Vein Thickness and Gold Grade in Drill Core from LaCodosera | 1994 | Economic Geology1994，89，： | 1 |
| 17 | Revisited显示文摘 | Many A Hubel R Robert JM'Hyperuricemia and Xanthine Oxidase in preeclampsia | 1996 | Am J obster Genecol1996，174，： | 1 |
| 18 | Phylogenetic relationships among members of the ascomycetous yeast genera Brettanomyces,Debaryomyces,Dekkera,and Kluyveromyces deduced by small-sabunit rRNA gene sequences显示文摘 | CAI J ROBERTS IN COLLINS M D | 1996 | Int J Syst Bacteriol1996，46，： | 1 |
| 19 | Chromosomal evolution in Saccharomyces显示文摘 | Fischer G James SA Roberts IN | 2000 | Nature2000，405，： | 1 |
| 20 | Dicynthaurin: an antimicrobial peptide from hemocytes of the solitary tunicate, Halocynthia aurantium显示文摘 | In Hee Lee Young Shin Lee Chong Han Kim Chung Ryul Kim Teresa Hong Lorenzo Menzel Lee Ming Boo Jan Pohl Mark A. Sherman Alan Waring Robert I. Lehrer | 2001 | BBA - General Subjects2001，，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员