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| 1 | Nature:死亡的肿瘤细胞释放出胞内钾离子来阻断免疫系统显示文摘在一项新的研究中。来自美国国家癌症研究所和英国巴布拉汉研究所的研究人员发现当肿瘤组织死亡时从它当中泄露出来的一种无机离子起着阻止抗肿瘤免疫细胞发挥功能的作用。这一发现为开发调动免疫系统抵抗癌症的疗法提供一种新的方法。相关研究结果在线发表在Nature期刊上。 | Robert Eil, Suman K. Vodnala, David Clever, Christopher A. Klebanoff, Madhusudhanan Sukumar, Jenny H. Pan, Douglas C. Palmer, Alena Gros, Tori N. Yamamoto, Shashank J. Patel, Geoffrey C. Guittard, Zhiya Yu, David S. Schrump, W. Marston Linehan, Nicholas P. Restifo Christopher A. Klebanoff Valentina Carbonaro, Klaus Okkenhaug, Rahul Roychoudhuri | 2016 | 现代生物医学进展2016，16，31： | 12 |
| 2 | Femtojoule electro-optic modulation using a silicon– organic hybrid device显示文摘Energy-efficient electro-optic modulators are at the heart of short-reach optical interconnects,and silicon photonics is considered the leading technology for realizing such devices.However,the performance of all-silicon devices is limited by intrinsic material properties.In particular,the absence of linear electro-optic effects in silicon renders the integration of energy-efficient photonic–electronic interfaces challenging.Silicon–organic hybrid(SOH)integration can overcome these limitations by combining nanophotonic silicon waveguides with organic cladding materials,thereby offering the prospect of designing optical properties by molecular engineering.In this paper,we demonstrate an SOH Mach–Zehnder modulator with unprecedented efficiency:the 1-mm-long device consumes only 0.7 fJ bit^(-1) to generate a 12.5 Gbit s^(-1) data stream with a bit-error ratio below the threshold for hard-decision forward-error correction.This power consumption represents the lowest value demonstrated for a non-resonant Mach–Zehnder modulator in any material system.It is enabled by a novel class of organic electro-optic materials that are designed for high chromophore density and enhanced molecular orientation.The device features an electro-optic coefficient of r33<180 pm V^(-1) and can be operated at data rates of up to 40 Gbit s^(-1). | Sebastian Koeber Robert Palmer Matthias Lauermann Wolfgang Heni Delwin L Elder Dietmar Korn Markus Woessner Luca Alloatti Swen Koenig Philipp C Schindler Hui Yu Wim Bogaerts Larry R Dalton Wolfgang Freude Juerg Leuthold Christian Koos | 2015 | Light(Science & Applications)2015，4，1： | 4 |
| 3 | 100 GHz silicon–organic hybrid modulator显示文摘Electro-optic modulation at frequencies of 100 GHz and beyond is important for photonic-electronic signal processing at the highest speeds.To date,however,only a small number of devices exist that can operate up to this frequency.In this study,we demonstrate that this frequency range can be addressed by nanophotonic,silicon-based modulators.We exploit the ultrafast Pockels effect by using the silicon–organic hybrid(SOH)platform,which combines highly nonlinear organic molecules with silicon waveguides.Until now,the bandwidth of these devices was limited by the losses of the radiofrequency(RF)signal and the RC(resistor-capacitor)time constant of the silicon structure.The RF losses are overcome by using a device as short as 500 μm,and the RC time constant is decreased by using a highly conductive electron accumulation layer and an improved gate insulator.Using this method,we demonstrate for the first time an integrated silicon modulator with a 3dB bandwidth at an operating frequency beyond 100 GHz.Our results clearly indicate that the RC time constant is not a fundamental speed limitation of SOH devices at these frequencies.Our device has a voltage–length product of only V_(π)L=11 V mm,which compares favorably with the best silicon-photonic modulators available today.Using cladding materials with stronger nonlinearities,the voltage–length product is expected to improve by more than an order of magnitude. | Luca Alloatti Robert Palmer Sebastian Diebold Kai Philipp Pahl Baoquan Chen Raluca Dinu Maryse Fournier Jean-Marc Fedeli Thomas Zwick Wolfgang Freude Christian Koos Juerg Leuthold | 2014 | Light(Science & Applications)2014，3，1： | 3 |
| 4 | Monitoring Greenhouses Gases over China Using Space-Based Observations Monitoring Greenhouses Gases over China Using Space-Based Observations显示文摘The atmospheric carbon dioxide(CO 2)concentration has increased to more than 405 parts per million(ppm.1 ppm=10-6 m/s 2)in 2017 due to human activities such as deforestation,land-use change and burning of fossil fuels.Although there is broad scientific consensus on the damaging consequences of the change in climate associated with increasing concentrations of greenhouse gases,fossil CO 2 emissions have continued to increase in recent years mainly from rapidly developing economies and China is now the largest emitter of CO 2 generating about 30%of all emissions globally.To allow more reliable forecast of the future state of the carbon cycle and to support the efforts for mitigation greenhouse gas emissions,a better understanding of the global and regional carbon budget is needed.Space-based measurements of CO 2 can provide the necessary observations with dense coverage and sampling to provide improved constrains on of carbon fluxes and emissions.The Chinese Global Carbon Dioxide Monitoring Scientific Experimental Satellite(TanSat)was established by the National High Technology Research and Development Program of China with the main objective of monitoring atmospheric CO 2 and CO 2 fluxes at the regional and global scale.TanSat has been successfully launched in December 2016 and as part of the Dragon programme of ESA and the Ministry of Science and Technology(MOST),a team of researchers from Europe(UK and Finland)and China has evaluated early TanSat data and contrast it against data from the GOSAT mission and models.In this manuscript,we report on retrieval intercomparisons of TanSat data using two different retrieval algorithms,on validation efforts for the Eastern Asia region using GOSAT CO 2 data and first assessments of TanSat and GOSAT CO 2 data against model calculations using the GEOS-Chem model. | Hartmut BOESCH Yi LIU Paul I PALMER Johanna TAMMINEN Jasdeep S ANAND Zhaonan CAI Ke CHE Huilin CHEN Xi CHEN Liang FENG Janne HAKKARAINEN Pauli HEIKKINEN Nikoleta KALAITZI Rigel KIVI Robert PARKER Peter SOMKUTI Jing WANG Alex WEBB Dongxu YANG Lu YAO You YI | 2020 | Journal of Geodesy and Geoinformation Science2020，3，4： | 2 |
| 5 | Primary feather vane asymmetry should not be used to predict the flight capabilities of feathered fossils显示文摘Reconstructing flight abilities of fossil birds from preserved wings and feathers is an important goal if we are to understand the evolution of flight.Wing-shape is known to correlate well with bird flight style[1],but functional wing-shape is almost impossible to reconstruct from fossils with a high degree of certainty.In contrast,however,individual primary feathers are often | Xia Wang Robert L.Nudds Colin Palmer Gareth J.Dyke | 2017 | Science Bulletin2017，62，18： | 2 |
| 6 | Deferoxamine posttreatment reduces ischemic brain injury in neonatal rats 显示文摘 | Palmer C Roberts R L Bero C | 1994 | Stroke1994，25，5： | 1 |
| 7 | Differential expression of chemokines and chemokine receptors during microglial activation and inhibition 显示文摘 | Kremlev SG Roberts RL Palmer C | 2004 | J Neuroimmunol2004，149，12： | 1 |
| 8 | Deferoxamine post treatment reduces ischemic brain injury in neonatal rats显示文摘 | Palmer C Roberts RL Bero C | 1994 | Stroke1994，25，5： | 1 |
| 9 | Differential expression of chemokines and chemokine receptors during micreglial activation and inhi- bition 显示文摘 | Kremlev SG Roberts RL Palmer C | 2004 | J Neuroimmunol2004，149，12： | 1 |
| 10 | RevaTen platelet-rich plasma improves cardiac function after myocardial injury显示文摘 | Allan Mishra Jeff Velotta Todd J. Brinton Xi Wang Stephanie Chang Owen Palmer Ahmad Sheikh Jaehoon Chung Phillip Chung-Ming Yang Robert Robbins Michael Fischbein | 2011 | Cardiovascular Revascularization Medicine2011，，3： | 1 |
| 11 | Differential expression of chemokines an chemokine receptors during microglial activation and inhibition显示文摘 | Kremlev S G Roberts R L Palmer C | 2004 | J Neuroimmunol2004，149，12： | 1 |
| 12 | Rapid communication:PCR RFLP for Msp I and Nco I in the ovine ealpastatin gene显示文摘 | Palmer B R Roberts N Hickford J G H | 1998 | J Anim Sci1998，76，： | 1 |
| 13 | Posttraumatic skeletal muscle proteolysis: The role of the hormonal environment显示文摘 | Palmer Q. Bessey M.D. Zhu-ming Jiang M.D. Daniel J. Johnson M.D. Robert J. Smith M.D. Douglas W. Wilmore M.D | 1989 | World Journal of Surgery1989，，4： | 1 |
| 14 | Deferoxamine post treatment re- duces ischemic brain injury in neonatal rats 显示文摘 | Palmer C Roberts RL Bero C | 1994 | Stroke1994，25，： | 1 |
| 15 | Deferoxamine post treatment reduces ischemic brain injury in neonatal rats 显示文摘 | Palmer C Roberts RL Bero C | 1994 | Stroke1994，25，5： | 1 |
| 16 | Differential expression of che- mokines and chemokine receptors during microglial activation and inhibition 显示文摘 | Kremlev SG Roberts RL Palmer C | 2004 | J Neuroimmuno12004，149，12： | 1 |
| 17 | Marker assisted selection for meat quality and the ovine calpastatin gene 显示文摘 | Palmer B R Morton J D Roberts N | 1999 | NZSAP Proceedings1999，59，： | 1 |
| 18 | Unusual clinical and immunologic manifestation of transplacentally acquired maternal T cells in severe combined immunodeficiency 显示文摘 | Palmer K Green TD Roberts JL | 2007 | J Allergy Clin lmmunol2007，120，2： | 1 |
| 19 | Differential expression of chemokines and chemokine receptors during microglial acti- vation and inhibition显示文摘 | Kremlev SG Roberts RL Palmer C | 2004 | J Neuroimmunol2004，149，12： | 1 |
| 20 | Deferoxamine posttreatment reduces ischemic brain injury in neonatal rats显示文摘 | Palmer C Roberts RL Bero C | | 0，，05： | 1 |
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