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| 1 | In-situ stress measurements and stress change monitoring to monitor overburden caving behaviour and hydraulic fracture pre-conditioning显示文摘A coal mine in New South Wales is longwall mining 300 m wide panels at a depth of 160–180 m directly below a 16–20 m thick conglomerate strata. As part of a strategy to use hydraulic fracturing to manage potential windblast and periodic caving hazards associated with these conglomerate strata,the in-situ stresses in the conglomerate were measured using ANZI strain cells and the overcoring method of stress relief. Changes in stress associated with abutment loading and placement of hydraulic fractures were also measured using ANZI strain cells installed from the surface and from underground. Overcore stress measurements have indicated that the vertical stress is the lowest principal stress so that hydraulic fractures placed ahead of mining form horizontally and so provide effective pre-conditioning to promote caving of the conglomerate strata. Monitoring of stress changes in the overburden strata during longwall retreat was undertaken at two different locations at the mine. The monitoring indicated stress changes were evident 150 m ahead of the longwall face and abutment loading reached a maximum increase of about7.5 MPa. The stresses ahead of mining change gradually with distance to the approaching longwall and in a direction consistent with the horizontal in-situ stresses. There was no evidence in the stress change monitoring results to indicate significant cyclical forward abutment loading ahead of the face. The forward abutment load determined from the stress change monitoring is consistent with the weight of overburden strata overhanging the goaf indicated by subsidence monitoring. | Puller Jesse W. Mills Ken W. Jeffrey Rob G. Walker Rick J. | 2016 | International Journal of Mining Science and Technology2016，26，1： | 5 |
| 2 | Frenetic显示文摘 | Nate Foster Rob Harrison Michael J. Freedman Christopher Monsanto Jennifer Rexford Alec Story David Walker | 2011 | ACM SIGPLAN Notices2011，，： | 1 |
| 3 | 自造冲锋枪显示文摘记者最近造访Defense Distributed时,这家非营利组织的氛围轻松随意,员工们上午10R到11点才开始陆续来上班。办公室位于得克萨斯州奥斯汀东北的一个办公园区,面积约170平方米,外面的唯一标识是门上的小企业协会贴纸。内部看起来跟其他小型制造商没什么两样。员工有15人左右,大部分是80后和90后男性,政治观点独特,他们一边组装着机器,一边交流着对唐纳德·特朗普(Donald Trump)的看法,他们都认为他荒唐至极,如果他上台,可能会带来丧心病狂的混乱局面。 | Rob Walker Bryan Schutmaat 贾慧娟 | 2016 | 商业周刊(中文版)2016，0，15： | 0 |
| 4 | 音频点播领域的达人显示文摘20岁的托妮.罗米蒂(Toni Romiti),穿着白色破洞牛仔裤和SoundCloud露脐T恤,在一屋子陌生人面前表演她一系列现代R&B风格歌曲当中的一首。然而,唱完开场曲后,她突然说道:“这是第一首。” | Rob Walker 杨飞 | 2015 | 商业周刊(中文版)2015，0，15： | 0 |
| 5 | 布拉德·皮特拯救下九区的计划毁誉参半显示文摘在2005年“卡特里娜”飓风过后的几个月中,围绕如何重建被洪水摧毁的新奥尔良社区,人们展开了大量的讨论。有些人甚至质疑某些地区是否应该重建:这个城市的人口可能会进一步减少;也许它的建筑发展足迹应该被修改?就拿下九区来说,因为受损程度如此严重,有人认为,这个在防洪堤破裂后被摧毁的黑人蓝领聚居区的重建就可能注定会失败。 | Rob Walker 杨飞(译) | 2019 | 商业周刊(中文版)2019，0，16： | 0 |
| 6 | Circulating microRNA expression and nonalcoholic fatty liver disease in adolescents with severe obesity显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is one of the most common chronic liver diseases in children and adolescents.NAFLD ranges in severity from isolated hepatic steatosis to nonalcoholic steatohepatitis(NASH),wherein hepatocellular inflammation and/or fibrosis coexist with steatosis.Circulating microRNA(miRNA)levels have been suggested to be altered in NAFLD,but the extent to which miRNA are related to NAFLD features remains unknown.This analysis tested the hypothesis that plasma miRNAs are significantly associated with histological features of NAFLD in adolescents.AIM To investigate the relationship between plasma miRNA expression and NAFLD features among adolescents with NAFLD.METHODS This study included 81 adolescents diagnosed with NAFLD and 54 adolescents without NAFLD from the Teen-Longitudinal Assessment of Bariatric Surgery study.Intra-operative core liver biopsies were collected from participants and used to characterize histological features of NAFLD.Plasma samples were collected during surgery for miRNA profiling.A total of 843 plasma miRNAs were profiled using the HTG EdgeSeq platform.We examined associations of plasma miRNAs and NAFLD features using logistic regression after adjusting for age,sex,race,and other key covariates.Ingenuity Pathways Analysis was used to identify biological functions of miRNAs that were associated with multiple histological features of NAFLD.RESULTS We identified 16 upregulated plasma miRNAs,including miR-193a-5p and miR-193b-5p,and 22 downregulated plasma miRNAs,including miR-1282 and miR-6734-5p,in adolescents with NAFLD.Moreover,52,16,15,and 9 plasma miRNAs were associated with NASH,fibrosis,ballooning degeneration,and lobular inflammation,respectively.Collectively,16 miRNAs were associated with two or more histological features of NAFLD.Among those miRNAs,miR-411-5p was downregulated in NASH,ballooning,and fibrosis,while miR-122-5p,miR-1343-5p,miR-193a-5p,miR-193b-5p,and miR-7845-5p were consistently and positively associated with all histological features of NAFLD.Pathway analysis revealed that most common pathways of miRNAs associated with multiple NAFLD features have been associated with tumor progression,while we also identified linkages between miR-122-5p and hepatitis C virus and between miR-199b-5p and chronic hepatitis B.CONCLUSION Plasma miRNAs were associated with NAFLD features in adolescent with severe obesity.Larger studies with more heterogeneous NAFLD phenotypes are needed to evaluate miRNAs as potential biomarkers of NAFLD. | Yi-Jie Li Brittney O Baumert Nikos Stratakis Jesse A Goodrich Hao-Tian Wu Jing-Xuan He Yin-Qi Zhao Max T Aung Hong-Xu Wang Sandrah P Eckel Douglas I Walker Damaskini Valvi Michele A La Merrill Justin R Ryder Thomas H Inge Todd Jenkins Stephanie Sisley Rohit Kohli Stavra A Xanthakos Andrea A Baccarelli Rob McConnell David V Conti Lida Chatzi | 2024 | World Journal of Gastroenterology2024，30，4： | 0 |
| 7 | 预言的代价 | Rob Walker 刘祥和 | 2001 | 数字财富2001，0，13： | 0 |
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