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| 1 | Immunotherapy and immunoescape in colorectal cancer显示文摘Immunotherapy encompasses a variety of interventions and techniques with the common goal of eliciting tumor cell destructive immune responses. Colorectal carcinoma often presents as metastatic disease that impedes curative surgery. Novel strategies such as active immunization with dendritic cells (DCs), gene transfer of cytokines into tumor cells or administration of immunostimulatory monoclonal antibodies (such as anti-CD137 or anti-CTLA-4) have been assessed in preclinical studies and are at an early clinical development stage. Importantly, there is accumulating evidence that chemotherapy and immunotherapy can be combined in the treatment of some cases with colorectal cancer, with synergistic potentiation as a result of antigens cross-presented by dendritic cells and/or elimination of competitor or suppressive T lymphocyte populations (regulatory T-cells). However, genetic and epigenetic unstable carcinoma cells frequently evolve mechanisms of immunoevasion that are the result of either loss of antigen presentation, or an active expression of immunosuppressive substances. Some of these actively immunosuppressive mechanisms are inducible by cytokines that signify the arrival of an effector immune response. For example, induction of 2, 3 indoleamine dioxygenase (IDO) by IFNγ in colorectal carcinoma cells. Combinational and balanced strategies fostering antigen presentation, T-cell costimulation and interference with immune regulatory mechanisms will probably take the stage in translational research in the treatment of colorectal carcinoma. | Guillermo Mazzolini Oihana Murillo Catalina Atorrasagasti Juan Dubrot Iigo Tirapu Miguel Rizzo Ainhoa Arina Carlos Alfaro Arantza Azpilicueta Carmen Berasain José L Perez-Gracia Alvaro Gonzalez Ignacio Melero | 2007 | World Journal of Gastroenterology2007，13，44： | 4 |
| 2 | Competition between fusion-evaporation and multifragmentation in central collisions in ^(58)Ni+^(48)Ca at 25A MeV显示文摘The experimental data concerning the58Ni+48Ca reaction at Elab(Ni)=25A MeV,collected by using the CHIMERA 4π device,have been analyzed in order to investigate the competition among different reaction mechanisms for central collisions in the Fermi energy domain.As a main criterion for centrality selection we have chosen the flow angle(flow) method,making an event-by-event analysis that considers the shape of events,as it is determined by the eigenvectors of the experimental kinetic-energy tensor.For the selected central events(flow >60°) some global variables,good to characterize the pattern of central collisions have been constructed.The main features of the reaction products were explored by using different constraints on some of the relevant observables,like mass and velocity distributions and their correlations.Much emphasis was devoted,for central collisions,to the competition between fusion-evaporation processes with subsequent identification of a heavy residue and a possible multifragmentation mechanism of a well defined(if any) transient nuclear system.Dynamical evolution of the system and pre-equilibrium emission were taken into account by simulating the reactions in the framework of transport theories.Different approaches have been envisaged(dynamical stochastic BNV calculations + sequential SIMON code,QMD,CoMD,etc.).Preliminary comparison of the experimental data with BNV calculations shows reasonable agreement with the assumption of sequential multifragmentation emission in the mass region of IMFs close to the heavy residues.Possible deviations from sequential processes were found for those IMFs in the region of masses intermediate between the mass of heavy residues and the mass of light IMFs.Further simulations are in progress.The experimental analysis will be enriched also by information obtained inspecting the IMF-IMF correlation function,in order to elucidated the nature of space-time decay property of the emitting source associated with events having the largest IMF multiplicity. | FRANCALANZA L ABBONDANNO U AMORINI F BARLINI S BINI M BOUGAULT R BRUNO M CARDELLA G CASINI G AGOSTINO M D' De FILIPPO V De SANCTIS J GERACI E GIUSSANI A GRAMEGNA F GUIOT B KRAVCHUK V La GUIDARA E LANZALONE G Le NEINDRE N MAIOLINO C MARINI P MORELLI L OLMI A PAGANO A PAPA M PIANTELLI S PIRRONE S POLITI G POGGI G PORTO F RUSSOTTO P RIZZO F VANNINI G VANNUCCI L | 2013 | Nuclear Science and Techniques2013，24，5： | 2 |
| 3 | Epidennal nevus syndrome:A neurologic variant with hemimegalencephaly, gyral malformation, mental retardation,seizures and facial hemihypertrophy显示文摘 | Pavone L Curatolo P Rizzo R | 1991 | Neurology1991，41，2： | 1 |
| 4 | HLA - G expression in early embryos is fundamental prerequisite for the obtainment of pregnancy 显示文摘 | Fuzzi B Rizzo R Criseuoli L | 2002 | Eur J Imrnunol2002，32，： | 1 |
| 5 | Bioremediationof a weathered and a recently oil-contaminated soils from Brazil:acomparison study显示文摘 | Trindade P V O Sobral L G Rizzo A C L | 2005 | Chemosphere2005，58，4： | 1 |
| 6 | Male breast cancer显示文摘 | Ottini L Palli D Rizzo S | 2010 | Crit Rev Oncol Hematol2010，73，2： | 1 |
| 7 | Diffusing capacity predicts morbidity and mortality after pulmonary resection显示文摘 | Ferguson MK Little L Rizzo L | 1988 | Thorac Cardiovasc Surg1988，96，6： | 1 |
| 8 | HLA-G expression in early embryos is a fundamental prerequisite for the obtain- ment of pregnancy显示文摘 | Fuzzi B Rizzo R Criscuoli L | 2002 | Eur J Immunol2002，32，： | 1 |
| 9 | Approach for oxygenation of the newborn with airway obstruction due to a cervical mass显示文摘 | Kelly MF Berenholz L Rizzo KA | 1990 | Ann Otol Rhinol Laryngol1990，99，31： | 1 |
| 10 | Rapid formation of high T-C phase in Bi-Pb-Sr(-∈)Ca-Cu-O system显示文摘 | Mancic L Milosevic O Rizzo F | 2000 | Physica C2000，，： | 1 |
| 11 | Synthesis of mesoporous SiO2- ZrO2 mixed oxides by sol-gel method显示文摘 | Flego C Carluccio L Rizzo C | 2001 | Catalysis Communications2001，2，2： | 1 |
| 12 | Study of saturation phenomena on asynchronous generators used in wind farms显示文摘 | Piegari L Rizzo R | 2004 | IEEE International Symposium on Industrial Electronics2004，2，： | 1 |
| 13 | HLA-G expression in early embryos is a fundamental prerequisite for the obtainment of pregnancy 显示文摘 | Fuzzi B Rizzo R Criscuoli L | 2002 | Eur J Immunol2002，32，2： | 1 |
| 14 | Improved properties of TiA1N coatings through the multilayer structure显示文摘 | RIZZO A MIRENGHI L MASSARO M | 2013 | Surface ~- Coatings Technology2013，235，： | 1 |
| 15 | Anchorage length of nearsurface mounted fiber-reinforced polymer bars for concrete strengthening-experimental investigation and numerical modeling concrete显示文摘 | DE LORENZIS L LUNDGREN K RIZZO A | 2004 | ACI Structural Journal2004，101，2： | 1 |
| 16 | 显示文摘 | Fuzzi B Rizzo R Criscuoli L | 2002 | Eur J Immonol2002，32，2： | 1 |
| 17 | HLA-G expression in early embryos is a fundamental prerequisite for the obtainment of pregnancy 显示文摘 | Fuzzi B Rizzo R Criscuoli L | 2002 | EurJ Immunol2002，32，2： | 1 |
| 18 | Use of epoetin and darbepoetin in patients with cancer: 2007 American Society of Hematology/American Society of Clinical Oncology clinical practice auideline uodate显示文摘 | Rizzo J D Somerfield M R Hagerty K L | 2008 | Blood2008，111，1： | 1 |
| 19 | HLA-G expression is a fundamental prerequisite to pregnancy显示文摘 | Melchiorri L Stignani M | 2007 | Hum Immunol2007，68，4： | 1 |
| 20 | What blindness can tell us about seeing again: merging neuroplasticity and neuro- prostheses显示文摘 | MEP ABET L B RIZZO J F AMEDI A | 2005 | Nat Rev Neurosei2005，6，1： | 1 |
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