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| 1 | 脑海绵状血管畸形临床诊疗指南概要:血管瘤联盟科学咨询委员会临床专家组基于系统文献评价的共识推荐显示文摘背景尽管脑海绵状血管畸形(cerebral cavernous malformation, CCM)的相关研究文献已相当丰富,但在诊断和治疗策略方面仍存在着争议。目的制订CCM诊疗指南。方法作为代表CCM患者和研究的患者支持团体,血管瘤联盟(www.angioma.org)召集了一个包括CCM临床专家在内的多学科写作组来帮助总结现有的CCM临床诊疗相关文献,重点关注5个主题:(1)流行病学和自然病程;(2)遗传检测和咨询;(3)诊断标准和影像学标准;(4)神经外科注意事项;(5)神经内科注意事项。写作组根据预定方案进行了文献回顾和证据评价,最终制定推荐意见,并且确立了共识、争议和知识空白。结果根据方法学标准从1983年1月1日至2014年9月31日期间公开发表的1 270篇文献中筛选出98篇,并确定了另外38篇近期或相关的文献。各主题作者利用这些文献总结了现有知识并形成了23项共识诊疗推荐,同时根据美国心脏协会/美国卒中协会标准进行了推荐强度(效应量)和证据水平(确定性估计)评级。其中,尚无A级证据(因为缺乏随机对照试验),B级证据11项(48%),C级证据12项(52%);Ⅰ级推荐8项(35%),Ⅱ级推荐10项(43%),Ⅲ级推荐5项(22%)。结论现有证据支持对CCM诊疗的推荐,但这些证据的级别和推荐强度普遍较低,因此需要进一步研究来帮助进行更好的临床实践并更新这些推荐。完整的推荐文档包括引用文献的纳入标准、关于各项推荐更详尽的评判标准以及各种争议和知识空白的总结,同样通过了同行评议并可在线获取(www.angioma.org/CCMGuidelines)。 | Amy Akers Rustam Al-Shahi Salman Issam A. Awad Kristen Dahlem Kelly Flemming Blaine Hart Helen Kim Ignacio Jusue-Torres Douglas Kondziolka Cornelia Lee Leslie Morrison Daniele Rigamonti Tania Rebeiz Elisabeth Toumier-Lasserve Darrel Waggoner Kevin Whitehead 鄂同舟 雷宇 倪伟 顾宇翔 | 2017 | 国际脑血管病杂志2017，25，7： | 4 |
| 2 | Etiology-related determinants of liver stiffness values in chronic viral hepatitis B or C显示文摘 | Mirella Fraquelli Cristina Rigamonti Giovanni Casazza Maria Francesca Donato Guido Ronchi Dario Conte Mariagrazia Rumi Pietro Lampertico Massimo Colombo | 2010 | Journal of Hepatology2010，，4： | 3 |
| 3 | PPARγ Activation Primes Human Monocytes into Alternative M2 Macrophages with Anti-inflammatory Properties显示文摘 | M. Amine Bouhlel Bruno Derudas Elena Rigamonti Rébecca Dièvart John Brozek Stéphan Haulon Christophe Zawadzki Brigitte Jude Gérard Torpier Nikolaus Marx Bart Staels Giulia Chinetti-Gbaguidi | 2007 | Cell Metabolism2007，，2： | 2 |
| 4 | Plasma ghrelin concentrations in elderly subjects:comparison with anorexic and obese patients显示文摘 | Rigamonti AE Pincelli AI Corm B | 2002 | J Endecrinoi2002，175，1： | 1 |
| 5 | The natural history of cavernous malformation显示文摘 | Moriarity JL Clatterbuck RE Rigamonti D | 1999 | Neurosurg Clin Am1999，10，： | 1 |
| 6 | Regulation of macrophage functions by PPAR-alpha, PPAR-gamma, and LXRs in mice and men 显示文摘 | Rigamonti E Chinetti-Gbaguidi G Staels B | 2008 | Arterioscler Thromb Vasc Biol2008，28，6： | 1 |
| 7 | The juxtaposition of a capillary telangiectasia, cavernous malformation, and developmental venous anomaly in the brainstem of a single patient: case report显示文摘 | Clatterbuck RE Elmaci I Rigamonti D | 2001 | Neurosurgery2001，49，5： | 1 |
| 8 | Interferon-gamma receptor 2 expression as the deciding factor in human T, B, and myeloid cell proliferation or death 显示文摘 | Bermabei P Coccia EM Rigamonti L | 2001 | J Leukoc Biol2001，70，6： | 1 |
| 9 | A longitudinal study of patients with venous malfomations:documentation of a negligible hanorrhage risk and benign natural history显示文摘 | Naff NJ Wemmer J Hoenig Rigamonti K | 1998 | Neu- rology1998，50，： | 1 |
| 10 | The natural history of cavernous malformations显示文摘 | Moriarity JL Clatterbuck RE Rigamonti D | 1999 | Neurosurg Clin Nor Am1999，10，3： | 1 |
| 11 | Mutations in KRIT1 in familial cerebral cavernous malformations 显示文摘 | Zhang J Richard EC Rigamonti D | 2000 | Neurosurg2000，46，： | 1 |
| 12 | Platinum coil treatment of complex aneurysms of the vertebrobasilar circulation显示文摘 | Y. Numaguchi P. H. Pevsner D. Rigamonti J. Ragheb | 1992 | Neuroradiology1992，，3： | 1 |
| 13 | Migraine, Celiac Disease, and Cerebral Calcifications: A New Case显示文摘 | Domenico D’Amico Andrea Rigamonti Luisa Spina Stefania Bianchi‐Marzoli Maurizio Vecchi Gennaro Bussone | 2005 | Headache: The Journal of Head and Face Pain2005，，9： | 1 |
| 14 | PPARgamma activation primes human monocytes into alternative M2macrophages with anti-inflammatory properties显示文摘 | Bouhlel MA Derudas B Rigamonti E | 2007 | Cell Metab2007，6，2： | 1 |
| 15 | chronic hepatitis c treated with phlebotomy alone:biochemical and histological outcome显示文摘 | Sartori M Andorno S Rigamonti C | 2001 | Dig Liver Dis2001，33，2： | 1 |
| 16 | Cavernous malformations: a review and current controversies 显示文摘 | Conway JE Rigamonti D | 2006 | Neurosurg Quart2006，16，1： | 1 |
| 17 | Heterozygous D9OA- SOD1 mutation in a patient with facial onset sensory motor neu- ronopathy (FOSMN) syndrome: a bridge to amyotrophic lateral scle- rosis显示文摘 | Dalla BE Rigamonti A Mantero V | 2014 | J Neurol Neurosurg Psychiatry2014，85，： | 1 |
| 18 | Morphometry of the renal corpuscle during normal postnatal growth and compensatory hypertrophy; a light microscope study 显示文摘 | Olivetti G Anversa P Rigamonti W | 1997 | Cell Biol1997，75，2： | 1 |
| 19 | Microsurgical fenestration of the lamina terminalis reduces the incidence of shunt - dependent hydrocephalus after aneurismal subarachnoid hemorrhage 显示文摘 | Komotar RJ Olivi A Rigamonti D | 2002 | Neurosurgery2002，51，6： | 1 |
| 20 | Loss of huntingtinmediated BDNF gene transcription in Huntington's disease显示文摘 | Zuccato C Ciammola A Rigamonti D | 2001 | Science2001，293，： | 1 |
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