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| 1 | Squamous cell carcinoma of the oral cavity and circulating tumour cells显示文摘Due to a lack of substantial improvement in the outcome of patients suffering from oral squamous cell carcinoma(OSCC) during the past decades, current staging methods need to be revised. This disease is associated with poor survival rates despite considerable advances in diagnosis and treatment. The early detection of metastases is an important indicator of survival, prognosis and relapse. Therefore, a better understanding of the mechanisms underlying metastasis is crucial. Exploring alternative measures apart from common procedures is needed to identify new prognostic markers. Similar to previous findings predominantly for other solid tumours, recently published studies demonstrate that circulating tumour cells(CTCs) and disseminated tumour cells(DTCs) might serve as prognostic markers and could supplement routine staging in OSCC. Thus, the detection of CTCs/DTCs is a promising tool todetermine the individual need for therapeutic intervention. Encouraging results and new approaches point to the future use of targeted therapies for OSCC, an exceedingly heterogeneous subgroup of head and neck cancer. This review focuses on summarising technologies currently used to detect CTCs/DTCs. The translational relevance for OSCC is highlighted. The inherent challenges in detecting CTCs/DTCs will be emphasised. | Johannes Wikner Alexander Grobe Klaus Pantel Sabine Riethdorf | 2014 | World Journal of Clinical Oncology2014，5，2： | 8 |
| 2 | Presence of EpCAM‐positive circulating tumor cells as biomarker for systemic disease strongly correlates to survival in patients with hepatocellular carcinoma显示文摘 | Kornelius Schulze Christin Gasch Katharina Staufer Bj?rn Nashan Ansgar W. Lohse Klaus Pantel Sabine Riethdorf Henning Wege | 2013 | Cancer2013，，9： | 2 |
| 3 | cancer: to bone marrow micrometastases, heterogeneous response to systemic therapy and low proliferative activity显示文摘 | Muller V Circulating correlation Stahmann N Riethdorf S tumor cells in breast | 2005 | Clin Cancer Res2005，11，： | 1 |
| 4 | Detection and HER2 expression of circulating tumor cells:prospective monitoring in breast cancer patients treated in the neoadjuvant GeparQuattro trial显示文摘 | Riethdorf S Müller V Zhang L | 2010 | Clin Cancer Res2010，16，9： | 1 |
| 5 | High incidence of EMMPRIN expression in human tumors显示文摘 | Riethdorf S Reimers N Assmann V | | 0，，08： | 1 |
| 6 | Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer:a validation study of the CellSearch system显示文摘 | Riethdorf S Fritsche H M tiller V | 2007 | Clin Cancer Res2007，13，3： | 1 |
| 7 | Strongly reduced expression of the cell cycle inhibitor p27 in endometrial neoplasia显示文摘 | Bamberger AM Riethdorf L Milde-Langosch K | 1999 | Virchows Arch1999，434，5： | 1 |
| 8 | Prognostic and predictive effects of immunohistochemical factors in high-risk primary breast cancer patients 显示文摘 | Kroger N Milde-Langoseh K Riethdorf S | 2006 | Clin cancer Res2006，12，1： | 1 |
| 9 | Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay显示文摘 | BACCELLl I SCHNEEWEISS A RIETHDORF S | 2013 | Nat Biotechnol2013，31，6： | 1 |
| 10 | Circulating tumor cells in breast cancer:correlation to bone marrow micrometastases,heterogeneous response to systemic therapy and low proliferative activity显示文摘 | Müller V Stahmann N Riethdorf S | 2005 | Clin Cancer Res2005，11，10： | 1 |
| 11 | Ki-67, cyclin E, and p 16^INK4A are complimentary surrogate biomarkers for human papilloma virus-related cervical neoplasia显示文摘 | Keating JT Cviko A Riethdorf S | 2001 | Am J Surg Pathol2001，25，7： | 1 |
| 12 | p16/MTS1 and PRB expression in endometrial carcinomas 显示文摘 | Milde LK Riethdorf L Bamberger AM | 1999 | Virchow Arch1999，434，1： | 1 |
| 13 | Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer:a validation study of the Cell Search system显示文摘 | RIETHDORF S FRITSCHE H MULLER V | 2007 | Clin Cancer Res2007，13，3： | 1 |
| 14 | Prospective monitoring of circulating tumor cells in breast cancer patients treated with primary systemic therapy-a translational project of the German Breast Group study GeparQnattro显示文摘 | Miiller V Riethdorf S Loibl S | 2007 | J Clin Oncol2007，25，21： | 1 |
| 15 | Cancer micrometastases显示文摘 | PANTEL K ALIX-PANABIERES C RIETHDORF S | 2009 | Nat Rev Clin Oncol2009，6，6： | 1 |
| 16 | P16/MTS1 and PRB expression in Endometrial carcinomas显示文摘 | MILDE L K RIETHDORF L BAMBERGER A M | 1999 | Virchow Arch1999，434，1： | 1 |
| 17 | Dysregulated expression of CD66a (BGP,C-CAM),an adhesion molecule of the CEA family in endometrial cancer显示文摘 | BAMBERGER A M RIETHDORF L NOLLAU P | 1998 | Am J Pathol1998，152，： | 1 |
| 18 | Role of cell-cycle regulatory proteins in gynecological cancer显示文摘 | MILDE-LANGOSCH K RIETHDORF S | 2003 | J Cell Physiol2003，196，2： | 1 |
| 19 | Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer:a validation study of the CellSearchTM system显示文摘 | Riethdorf S Fritsche H Müller V | 2007 | Clin Cancer Res2007，13，3： | 1 |
| 20 | High incidence of EMMPRIN expression in human tumors 显示文摘 | Riethdorf S Reimers N Assmann V | 2006 | Int J Cancer2006，119，8： | 1 |
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