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1篇 您的检索式:作者名="Rierre RENARD"
    题名 作者 年代 出处 被引量
1S-21007,强效5-羟色胺3受体部份激动剂,对小鼠焦虑的作用(英文)显示文摘AIM: To study the effect of S-21007, a 5-HT_3partial agonist in different animal models of anxiety inmice. METHODS: S-21007 effects were evaluatedin the behavior tests after intraperitioneal and oral acutetreatment or in the light/dark test after both acute andchronic treatments. RESULTS: S-21007 presentedanxiolytic-like properties after acute administration inthe light/dark box test, the mirrored chamber test, andthe elevated plus-maze at be doses 10 ng·kg^(-1)-100μg·kg^(-1), 1-100 μg·kg^(-1) and 10-100 μg·kg^(-1),respectively. In the light/dark box test, S-21007 wasactive orally after acute treatment at 100 ng·kg^(-1)-10mg·kg^(-1) and after chronic treatment (14 d) at 1-10μg·kg^(-1). S-21007 was devoid of sedative or stimula-Philippe DELAGRANGE René MISSLIN Thomas W SEALE Bruno PFEIFFER Sylvain RAULT Rierre RENARD 1999中国药理学报1999,20,9:0
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