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您的检索式：作者名="Rick B.Meeker"
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| 1 | The p75 neurotrophin receptor:at the crossroad of neural repair and death显示文摘The strong repair and pro-survival functions of neurotrophins at their primary receptors,Trk A,Trk B and Trk C,have made them attractive candidates for treatment of nervous system injury and disease.However,difficulties with the clinical implementation of neurotrophin therapies have prompted the search for treatments that are stable,easier to deliver and allow more precise regulation of neurotrophin actions.Recently,the p75 neurotrophin receptor(p75NTR) has emerged as a potential target for pharmacological control of neurotrophin activity,supported in part by studies demonstrating 1) regulation of neural plasticity in the mature nervous system,2) promotion of adult neurogenesis and 3) increased expression in neurons,macrophages,microglia,astrocytes and/or Schwann cells in response to injury and neurodegenerative diseases.Although the receptor has no intrinsic catalytic activity it interacts with and modulates the function of Trk A,Trk B,and Trk C,as well as sortilin and the Nogo receptor.This provides substantial cellular and molecular diversity for regulation of neuron survival,neurogenesis,immune responses and processes that support neural function.Upregulation of the p75 NTR under pathological conditions places the receptor in a key position to control numerous processes necessary for nervous system recovery.Support for this possibility has come from recent studies showing that small,non-peptide p75 NTR ligands can selectively modify pro-survival and repair functions.While a great deal remains to be discovered about the wide ranging functions of the p75 NTR,studies summarized in this review highlight the immense potential for development of novel neuroprotective and neurorestorative therapies. | Rick B.Meeker Kimberly S.Williams | 2015 | Neural Regeneration Research2015，10，5： | 12 |
| 2 | The new wave of p75 neurotrophin receptor targeted therapies显示文摘Neurotrophins have been recognized for decades for their beneficial effects on growth,survival,and maintenance in the central nervous system,all of which suggest potential therapeutic utility.Although understanding and harnessing the activity of neurotrophins has proven difficult,the past several years have seen significant strides in the development of deliverable therapies that modulate neurotrophin activity(Shen et al.,2019;Yang et al.,2020;Xie et al.,2021).These recent studies have primarily focused on the multifunctional p75 neurotrophin receptor(p75NTR)which is upregulated in central nervous system disease and injury,thus offering a unique target for intervention. | Amanda M.Crooks Rick B.Meeker | 2022 | Neural Regeneration Research2022，17，1： | 0 |
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