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| 1 | Alpha-fetoprotein expression is a potential prognostic marker in hepatocellular carcinoma显示文摘AIM: To characterize the alpha-fetoprotein (AFP) positive and negative hepatocellular carcinoma (HCC) samples.METHODS: Thirty-seven paraffin-embedded human HCC samples were analyzed by immunohistochemistry for the following antigens: AFP, β-catenin, p53, CD44, MSH-2,MLH-1, and HNF-4. The tumors were divided into two groups based on the AFP expression. The immunophenotypic data and important clinical parameters were studied between the two groups.RESULTS: Twenty-one of the thirty-seven examined HCCs were AFP positive. Seven with nuclear p53 staining were AFP positive, while seven tumors with nuclear β-catenin staining were AFP negative. CD44 staining and high histological tumor grade were more frequent among the AFP-positive HCCs. The other immunophenotypical and dinical parameters did not show statistically significant difference in their distribution between the AFP positive and negative samples.CONCLUSION: AFP expression in HCC correlates with unfavorable prognostic factors, while nuclear β-catenin positivity is more common among the AFP-negative liver tumors. This observation supports the microarray data onin vivo human tumors. | Dénes Grg János Regly-Mérei Sándor Paku László Kopper Péter Nagy | 2005 | World Journal of Gastroenterology2005，11，32： | 6 |
| 2 | An automated spring-loaded needle for endoscopic ultrasound-guided abdominal paracentesis in cancer patients显示文摘AIM: To evaluate the feasibility of using an automatedspring-loaded needle device for endoscopic ultrasound(EUS)-guided abdominal paracentesis(EUS-P) to see if this would make it easier to puncture the mobile and lax gastric wall for EUS-P.METHODS: The EUS database and electronic medical records at Fukushima Medical University Hospital were searched from January 2001 to April 2011. Patients with a history of cancer and who underwent EUS-P using an automated spring-loaded needle device with a 22-gauge puncture needle were included. The needle was passed through the instrument channel and advanced through the gastrointestinal wall under EUS guidance into the echo-free space in the abdominal cavity and ascitic fluid was collected. The confirmed diagnosis of malignant ascites included positive cytology and results from careful clinical observation for at least 6 mo in patients with negative cytology. The technical success rate, cytology results and complications were evaluated.RESULTS: We found 11 patients who underwent EUS-P with an automated spring-loaded needle device. In 4 cases, ascites was revealed only with EUS but not in other imaging modalities. EUS-P was done in 7 other cases because there was minimal ascitic fluid and no safe window for percutaneous abdominal aspiration. Ascitic fluid was obtained in all cases by EUS-P. The average amount aspirated was 14.1 mL(range 0.5-38 mL) and that was sent for cytological exam. The etiology of ascitic fluid was benign in 5 patients and malignant in 6. In all cases, ascitic fluid was obtained with the first needle pass. No procedure-related adverse effects occurred.CONCLUSION: EUS-P with an automated springloaded needle device is a feasible and safe method for ascites evaluation. | Rei Suzuki Atsushi Irisawa Manoop S Bhutani Takuto Hikichi Tadayuki Takagi Goro Shibukawa Ai Sato Masaki Sato Tsunehiko Ikeda Ko Watanabe Jun Nakamura Srinadh Annangi Kazuhiro Tasaki Katsutoshi Obara Hiromasa Ohira | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，2： | 3 |
| 3 | 非洲猪瘟——威胁全球猪业的重要疾病重现江湖:基本概况显示文摘近期,非洲猪瘟(African Swine Fever,ASF)已经从撒哈拉以南的非洲国家传播到南高加索地区、俄罗斯联邦部分地区和东欧。在新一轮流行病学事件中,此次流行的ASF与其在非洲的情况有相似性,但仍有重要的差异,包括野猪的实际影响。更好地了解这种新形势能够有效地控制该病,并阻止该病的进一步传播。本文将会对这些不同情境进行比较,并讨论非洲猪瘟病毒(African Swine Fever Virus,ASFV)毒株发病机理的最新信息、动物对感染的免疫应答以及疫苗的研发前景等。本文还将讨论现有知识的差异和未来控制展望。 | 贾良梁(译) 夏俊花(审) P. J. Sánchez-Cordón M. Montoya A. L. Reis L. K. Dixon | 2019 | 国外畜牧学(猪与禽)2019，39，4： | 3 |
| 4 | 非洲猪瘟——威胁全球猪业的重要疾病重现江湖:发病机制和疫苗研发显示文摘本文是《非洲猪瘟——威胁全球猪业的重要疾病重现江湖》的第二部分,主要介绍非洲猪瘟病毒东欧分离株的试验性发病机制和疫苗研发情况。 | 贾良梁(译) 夏俊花(审) P. J. Sánchez-Cordón M. Montoya A. L. Reis L. K. Dixon | 2019 | 国外畜牧学(猪与禽)2019，39，4： | 3 |
| 5 | Innate antiviral responses by means of TLRT-mediated recognition of single-stranded RNA显示文摘 | Diebold S S Kaisho T Hemmi H Akira S Reis e Sousa C | 2004 | Science2004，303，： | 1 |
| 6 | Integrated transport and reaction in an ion exchange membrane bioreactor 显示文摘 | Velizarov S Reis M A M Crespo J G | 2002 | Desali- nation2002，149，13： | 1 |
| 7 | High performance tangential flow filtration 显示文摘 | van Reis R Gadam S Frautschy L N | 1997 | Biotechnol Bioeng1997，56，： | 1 |
| 8 | Rituximab and alemtuzumabinduce a nonclassic,caspase independent apoptic pathway in lymphoid cell lines and in chronic lymphocytic leukemiacells显示文摘 | Stangl maier M Reis S Hallek M | 2004 | Ann Hematol2004，83，10： | 1 |
| 9 | Tha history of neurosurgical procedures for moyamoya disease显示文摘 | Reis CV Safavi-Abbasi S Zabramski JM | 2006 | Neurosurg Focus2006，20，： | 1 |
| 10 | Competition between nitrate and nitrite reduction in denitrification by Pseudomonas fluorescens显示文摘 | Almeida J S Reis M Carrondo M | 1995 | Biotech Bioeng1995，46，： | 1 |
| 11 | Inhibins in female and male reproductive physiology:role in gametogenesis,conception,implantation and early pregnancy显示文摘 | Luisi S Florio P Reis FM | | 0，，02： | 1 |
| 12 | Treatment of patients admitted to the hospital with congestive heart failure:Specialty-related disparities in practice patterns and outcomes显示文摘 | REIS S E HOLUBKOV R EDMUNDOWICZ D | 1997 | J Am Coll Cardiol1997，30，： | 1 |
| 13 | Removal of inorganic charged micro-pollutants in an ion-exchange membrane bioreactor 显示文摘 | Velizarov S Matos C Reis M A M | 2005 | Desalination2005，178，13： | 1 |
| 14 | Chronic idiopathic constipation:a psychological enquiry显示文摘 | Dykes S Smigin2hump reys S Bass C | 2001 | Eur J Gastroenterol H epatol2001，13，： | 1 |
| 15 | Simple sequence repeats in Cucumis mapping and map merging显示文摘 | Danin-Poleg Y Reis N Baudracco-Arnas S | 2000 | Genome2000，43，6： | 1 |
| 16 | The accessorymiddle cerebral artery: anatomic report显示文摘 | Reis CV Zabramski JM Safavi-Abbasi S | 2008 | Neurosurgery2008，63，11： | 1 |
| 17 | Early adolescent participa- tion in physical activity: correlates with individual and family characteristics显示文摘 | MULHALL P REIS J BEGUM S | 2011 | J Phys Act Heal2011，8，： | 1 |
| 18 | Removal of trace mono-valent inorganic pollutants in an ion exchange membrane bioreactor: analysis of transport rate in a denitrification process 显示文摘 | VELIZAROV S REIS M A CRESPO J G | 2003 | Journal of Membrane Science2003，217，12： | 1 |
| 19 | Expression and secretion of activin A:possible physiological and clinical implications显示文摘 | Luisi S Florio P Reis FM | 2001 | Eur J Endocrinol2001，145，4： | 1 |
| 20 | Aroma ageing trends in GC/MS profiles of liqueur wines显示文摘 | Pereira A C Reis M S Saraiva P M | 2010 | Anal Chim Acta2010，659，： | 1 |
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