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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Functional imaging of an illusion of pain显示文摘 | Craig A D Reiman E M Evans A | 1996 | Nature1996，384，： | 1 |
| 3 | Interleukin-6 polymorphism is associated with chorioamnionitis and neonatal infections in preterm infants 显示文摘 | Reiman M Kujari H Ekholm E | 2008 | J Pediatr2008，153，1： | 1 |
| 4 | Principles of adaptive management in complex safety-critical organiza- tions 显示文摘 | Reiman T Rollenhagen C Pietik/iinen E | 2015 | Safety Sci2015，71，： | 1 |
| 5 | Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia显示文摘 | Reiman E M Chen K Alexander G E | 2004 | Proc Natl Acad Sci U S A2004，101，： | 1 |
| 6 | Brain imaging in the study of Alzheimer's disease 显示文摘 | REIMAN E M JAGUST W J | 2012 | Neuroimage2012，61，2： | 1 |
| 7 | GAB2 al- leles modify Alzheimer's risk in APOE epsilon4 carriers 显示文摘 | Reiman E M Webster J A Myers A J | 2007 | Neuron2007，54，5： | 1 |
| 8 | CIND and MCI in the Italianelderly: frequency, vascular risk factors,progression to dementia显示文摘 | Solfrizzi V Reiman E Caselli RJ | 2007 | Neurology2007，69，23： | 1 |
| 9 | Neuroanatomical correlates of veridical and illusory recognition memory: evidence from positron emission tomography显示文摘 | Schacter DL Reiman E Curran T | 1996 | Neuron1996，17，2： | 1 |
| 10 | Neural correlates of levels of emotional awareness:Evidence of an interaction between emotion and attention in the anterior cingulate cortex显示文摘 | Reiman E M Axelrod B | 1998 | Journal of Cognitive Neuroscience1998，10，4： | 1 |
| 11 | Neuroanatomical correlates of a lactate-induced anxiety attack 显示文摘 | Reiman EM Raichle ME Robins E | 1989 | Arch Gen Psychiatry1989，46，6： | 1 |
| 12 | Interleukin-6 polymorphism is associated with ehorioamnionitis and neonatal infections in preterm infants显示文摘 | Reiman M Kujari H Ekholm E | 2008 | J Pediatr2008，153，1： | 1 |
| 13 | Fibrillar amyloid-f3 burden in cognitively normal people at 3 levels of genetic risk for Alzhimer’s disease 显示文摘 | Reiman E Chen K Liu X | 2009 | Proceedings of the National Academy of Sciences2009，106，： | 1 |
| 14 | Alzheimer's Prevention Initiative: a plan to accelerate theevaluation of presymptomatic treatments显示文摘 | REIMAN E M LANGBAUM J B S FLEISHER A S | 2011 | J Alzheimers Dis2011，26，3： | 1 |
| 15 | Fibrillar amyloid-beta burden in cognitively normal peo- ple at 3 levels of genetic risk for Alzheimer's disease显示文摘 | Reiman E M Chen K Liu X | | 0，，： | 1 |
| 16 | Alzheimer' s disease is associated with reduced expression of energy metabolism genes in posterior cingulate neurons 显示文摘 | Liang W S Reiman E M Valla J | 2008 | Proc Natl Aead Sci USA2008，105，11： | 1 |
| 17 | Linking functional and structural brain images with multivariate network ana- lyses: a novel application of the partial least square method 显示文摘 | Chen K Reiman E M Huan Z | 2009 | Neuroimage2009，47，2： | 1 |
| 18 | Noninvasive quantification of the cerebral metabolic rate for glucose using positron emission tomography,F-18-fluoro 2-deoxyglucose,the Patlak method,and an image-derived input function显示文摘 | Chen K Bandy D Reiman E | 1998 | J Cereb Blood Flow Metab1998，18，7： | 1 |
| 19 | Hippocampal volumes in cognitively normal persons at genetic risk for Alzheimer disease显示文摘 | Uecker A Caselli R | 1998 | Ann Neurol1998，44，： | 1 |
| 20 | Preclinical memory decline in cognitively normal apolopoprotein E epsilon 4 homo-zygotes显示文摘 | Graff-Radford N Reiman E | 1999 | Neurology1999，53，： | 1 |
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