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| 1 | Erratum to: “Multi-symplectic integration methods for Hamiltonian PDEs” [Future Gen. Comput. Sys. 19 (2003) 395–402]显示文摘 | Brian E Moore Sebastian Reich | 2003 | Future Generation Computer Systems2003，，4： | 1 |
| 2 | Multi-symplectic integrators: numerical schemes for Hamiltonian PDEs that conserve symplecticity显示文摘 | Thomas J. Bridges Sebastian Reich | 2001 | Physics Letters A2001，，4： | 1 |
| 3 | Multi-symplectic spectral discretizations for the Zakharov–Kuznetsov and shallow water equations显示文摘 | Thomas J. Bridges Sebastian Reich | 2001 | Physica D: Nonlinear Phenomena2001，，： | 1 |
| 4 | Multi-Symplectic Runge–Kutta Collocation Methods for Hamiltonian Wave Equations显示文摘 | Sebastian Reich | 2000 | Journal of Computational Physics2000，，2： | 1 |
| 5 | On the local qualitative behavior of differential-algebraic equation显示文摘 | Sebastian Reich | 1995 | Circuit Systems Signal Process1995，14，4： | 1 |
| 6 | Muhi-symplectic integrators: numerical schemes for Hamihonian PDEs that conserve symplecticity 显示文摘 | Bridges T J Reich Sebastian | 2001 | Physics Letter A2001，284，45： | 1 |
| 7 | Multi-symplectic spectral discretizations for the Zakharov–Kuznetsov and shallow water equations显示文摘 | Thomas J. Bridges Sebastian Reich | 2001 | Physica D: Nonlinear Phenomena2001，，： | 1 |
| 8 | Multi-symplectic spectral discretizations for the Zakharov-Kuznetsov and shallow water equations显示文摘 | Bridges T J Reich Sebastian | 2001 | Physica D2001，，152153： | 1 |
| 9 | Multi -symplectic Runge -Kutta collocation methods for Hamiltonian wave equations显示文摘 | Sebastian Reich | 2000 | Comp Phys2000，157，： | 1 |
| 10 | Potential use of data-mining algorithms for the detection of 'surprise' adverse drug reactions显示文摘 | Sebastian Horn Lester Reich | 2007 | Drug safety2007，30，： | 1 |
| 11 | On the local qualitative behavior of differential-algebraic equation显示文摘 | Sebastian Reich | 1995 | Circuit Systems Signal Process1995，14，4： | 1 |
| 12 | Use of Data-Mining Algorithms for the Detection of surprise Adverse Drug Reactions显示文摘 | Manfred Hauben Sebastian Horn Lester Reich Potential | 2007 | DrugSaf2007，30，2： | 1 |
| 13 | Multi-symplectic Runge-Kutta collocation methods for Hamiltonian wave equations 显示文摘 | Sebastian Reich | 2000 | J Comput Phys2000，157，： | 1 |
| 14 | Multimodal 4-arylchromene derivatives with microtubule-destabilizing,anti-angiogenic,and MYB-inhibitory activities显示文摘Aim:Efficient and readily available anticancer drugs are sought as treatment options.For this reason,chromene derivatives were prepared using the one-pot reaction and tested for their anticancer and anti-angiogenic properties.Methods:2-Amino-3-cyano-4-(aryl)-7-methoxy-4H-chromene compounds(2A-R)were repurposed or newly synthesized via a three-component reaction of 3-methoxyphenol,various aryl aldehydes,and malononitrile.We performed assays to study the inhibition of tumor cell growth[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromid(MTT)assay],effects on microtubules(immunofluorescence),cell cycle(flow-activated cell sorting analysis),angiogenesis(zebrafish model),and MYB activity(luciferase reporter assay).Fluorescence microscopy was applied for localization studies via copper-catalyzed azide-alkyne click reaction of an alkyne-tagged drug derivative.Results:Compounds 2A-C and 2F exhibited robust antiproliferative activities against several human cancer cell lines(50%inhibitory concentrations in the low nanomolar range)and showed potent MYB inhibition.The alkyne derivative 3 was localized in the cytoplasm after only 10 min of incubation.Substantial microtubule disruption and G2/M cell-cycle arrest were observed,where compound 2F stood out as a promising microtubule-disrupting agent.The study of anti-angiogenic properties showed that 2A was the only candidate with a high potential to inhibit blood vessel formation in vivo.Conclusion:The close interplay of various mechanisms,including cell-cycle arrest,MYB inhibition,and anti-angiogenic activity,led to identifying promising multimodal anticancer drug candidates. | Leonhard H.F.Kohler Sebastian Reich Maria Yusenko Karl-Heinz Klempnauer Gerrit Begemann Rainer Schobert Bernhard Biersack | 2023 | Cancer Drug Resistance2023，6，1： | 0 |
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