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| 1 | 子痫前期:病理生理学和临床意义显示文摘子痫前期是一种常见疾病,尤其影响首次妊娠。其临床表现多样,但通常表现为高血压和蛋白尿。这些全身症状是由于在合体滋养细胞的压力作用下,胎盘释放了可溶性因子。子痫前期主要有早发型和迟发型2种亚型,其他几种亚型目前尚未确定。早发型子痫前期是由于胎盘缺陷而出现,而迟发型子痫前期可能是由于胎盘的正常衰老,以及母体对心血管和代谢疾病的遗传易感性交互产生。子痫前期因胎盘和母体因素产生的原因因人而异。最近的研究主要集中在早孕期的胎盘-子宫相互作用。本文旨在对关于子痫前期的预测、预防和治疗方法的最新文献进行归纳综述。 | Graham J Burton Christopher W Redman James M Roberts Ashley Moffett 秦萌(译) 金滢 潘凌亚(校 | 2019 | 英国医学杂志中文版2019，22，11： | 6 |
| 2 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 3 | A new RNA-friendly fixative for the preservation of penaeid shrimp samples for virological detection using eDNA genomie probes显示文摘 | Hasson K W Hasson J Aubert H Redman R M Lightner D V | 1997 | J Virol Methods1997，66，2： | 1 |
| 4 | Activity of SUl1248, a muhitargeted inhibitor of vascular endothelial growth faclor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma 显示文摘 | Motzer R J Michaelson MD Redman BG | 2006 | J Clin Oncol2006，24，1： | 1 |
| 5 | Reversed diurnal blood pressure rhythm in hypertensive pregnancies显示文摘 | Redman CW Beilin LJ Bonnar J | 1976 | Clin Sci Mol Med Suppl1976，3，： | 1 |
| 6 | Age-dependent effects of jasmonic acid treatment and wind exposure on foliar oxidase activity and insect resistance in to mato显示文摘 | Cipollini D F J R Redman A M | 1999 | Journal of Chemical Ecology1999，25，2： | 1 |
| 7 | Abiotic and biotic stress differentially stimulate as-1 element activity in Arabidopsis 显示文摘 | Redman J Whiteraft J Johnson C | 2002 | Plant Cell Rep2002，21，： | 1 |
| 8 | Loss of heterozygosity at chromosome 9q22-31 is a frequent and early event in ovarian tumors显示文摘 | Byrom J Mudaliar V Redman CW | 2004 | Int J Oncol2004，24，5： | 1 |
| 9 | Glucose in bronchial aspirates increases the risk of respiratory MRSA in intubated patients显示文摘 | philipb BJ Redman J Brennan A | 2005 | Thorax2005，60，9： | 1 |
| 10 | Buried penis :congenital syndrome of a short penile shaft and a paucity of penile shaft skin显示文摘 | Redman J F | 2005 | J Urol2005，173，5： | 1 |
| 11 | Lorcaserin, a 5-HT (2C)receptor agonist, reduces body weight by decreasing energy intake without influencing energy expenditure 显示文摘 | Martin CK Redman LM Zhang J | 2011 | J Clin Endocrinol Metab2011，96，3： | 1 |
| 12 | The role of fungal symbioses in the adaptation of plant to high stress environments显示文摘 | RODRIGUEZ R J REDMAN R S HENSON J M | 2004 | Mitigat Adaptat Strateg Glob Change2004，9，3： | 1 |
| 13 | Synthesis and antibacterial activity study of a novel class of cationic anthraquinone ana- logs 显示文摘 | Zhang J Redman N Litke AP | 2011 | Bioorg Med Chem2011，19，1： | 1 |
| 14 | Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma 显示文摘 | Motzer R J Michaelson M D Redman B G | 2006 | J CIin Oncol2006，24，1： | 1 |
| 15 | Time of Day Variations in Driving Performance显示文摘 | Lenne M G Triggs T J Redman J R | 1997 | Accident Analysis and Prevention1997，29，4： | 1 |
| 16 | Acupuncture for ovulation induction in polycystic ovary syndrome:a randomized controlled trial显示文摘 | Johansson J Redman L Veldhuis PP | 2013 | Am J Physiol Endocrinol Metab2013，304，9： | 1 |
| 17 | Cnmparing Air Pollution fi'om Ferry and Landside Com- muting显示文摘 | FARRELL A E REDMAN D H CORBETF J J | 2003 | Transportation Research Part D2003，，8： | 1 |
| 18 | Fungal symbiosis:from mutualism to parasitism,who control the outcome,host or invader显示文摘 | Dunigan D D Rodriguez R J | 2001 | New Phytologist2001，151，3： | 1 |
| 19 | Activity of SUl1248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor re- ceptor, in patients with metastatic renal cell carcinoma 显示文摘 | Motzer R J Michaelson MD Redman BG | 2006 | J Clin Oncol2006，24，1： | 1 |
| 20 | Measring soil water content with ground penetrating radar: A review 显示文摘 | Huisman J A Hubbard S S Redman J D | 2003 | Vadose Zone J2003，，2： | 1 |
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