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| 1 | Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity显示文摘Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous genome.Phased assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous chromosomes.Wild species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding efforts.As a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid potato.Nearly a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic load.The StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent manner.Knowledge of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids. | Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers | 2022 | Molecular Plant2022，15，3： | 4 |
| 2 | Management of advanced squamous cell, Carcinomas of the maxillary sinas显示文摘 | Girl SPC Reddy EK Gemez LS | 1992 | Cancer1992，69，： | 1 |
| 3 | Radiotherapy alone in esophageal carcinoma: current management and future directions of adjuvant, curative and palliative approaches显示文摘 | Smalley SR Gunderson LL Reddy EK | 1994 | Semin Oncol1994，21，4： | 1 |
| 4 | Major Issues of Web Applications:A Case Study of SQL Injection显示文摘 | TK Rao GY Kumar EK Reddy | | 0，，01： | 1 |
| 5 | A sia– P acific consensus recommendations for endoscopic and interventional management of hilar cholangiocarcinoma显示文摘 | Rungsun Rerknimitr Phonthep Angsuwatcharakon Thawee Ratanachu‐ek Christopher J L Khor Ryan Ponnudurai Jong Ho Moon Dong Wan Seo Linda Pantongrag‐Brown Apichat Sangchan Pises Pisespongsa Thawatchai Akaraviputh Nageshwar D Reddy Amit Maydeo Takao Itoi Nonth | 2013 | J Gastroenterol Hepatol2013，，4： | 1 |
| 6 | Tympanoplasty with and without cortical mastoidectomy-a compara-tive study显示文摘 | Krishnan A Reddy EK Chandrakiran C | 2002 | Int J Otolaryngol Head Neck Surg2002，54，： | 1 |
| 7 | Radiotherapy alone in esophageal carcinoma:current management and future directions of adjuvant, curative palliative approaches显示文摘 | Smalley SR Gunderson LL Reddy EK | 1994 | Seroin Oncol1994，21，4： | 1 |
| 8 | Radiotherapy alone in esophageal carcinoma: Current management and future directiones of adjuvant, curative and palliative approaches显示文摘 | Smallery SR Gunderson LL Reddy EK | 1994 | Seminars in Oncology1994，2，： | 1 |
| 9 | High resolution, short echo time sodium imagingg of articular cartilage显示文摘 | Insko EK Reddy R Leigh JS | 1997 | J Magn Reson Imaging1997，7，3： | 1 |
| 10 | 显示文摘 | Harrop JA Reddy M Ded EK | 1998 | J Immunol1998，161，4： | 1 |
| 11 | ^89Sr for palliation of bone metastases显示文摘 | Reddy Ek Robinson RG Mansfield CM | 1986 | J Natl Med Assoc1986，78，： | 1 |
| 12 | Management of Advanced Squamons Cell Carcinomas of the Maxillary Sinus显示文摘 | Giri SPG Reddy EK Gemez LS | 1992 | Cancer1992，69，3： | 1 |
| 13 | Radiotherapy alone in esophageal carcinoma显示文摘 | Smalley SR Gunderson LL Reddy EK | 1994 | Semin Oncol1994，21，4： | 1 |
| 14 | Radiotherapy alone in esophageal carcinoma:Current management and future directions of adjuvant,curative and palliative approaches显示文摘 | Smallery SR Gunderson LL Reddy EK | 1994 | Seminars in Oncology1994，2，： | 1 |
| 15 | Primary orbital Lymphomas 显示文摘 | Bhatia PM Evans RG | 1988 | IntJ Radiat Oncol Biol Phys1988，15，5： | 1 |
| 16 | Radiotherapy alone in esophageal carcinoma:current management and future directions of adjuvant,curative and palliative approaches显示文摘 | Smallery SR Gunderson LL Reddy EK | 1994 | Semin Oncol1994，2，： | 1 |
| 17 | Radiotherapy alone in esophageal carcinoma cuurent managemeng and future directions of adjuvant,curative and paltiativeapproaches 显示文摘 | Smallery SR Gunderson LL Reddy EK | 1994 | Semin Onol1994，21，4： | 1 |
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