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| 1 | Laser patterning for the study of MSC cardiogenic differentiation at the single-cell level显示文摘Mesenchymal stem cells(MSCs)have been cited as contributors to heart repair through cardiogenic differentiation and multiple cellular interactions,including the paracrine effect,cell fusion,and mechanical and electrical couplings.Due to heart–muscle complexity,progress in the development of knowledge concerning the role of MSCs in cardiac repair is heavily based on MSC–cardiomyocyte coculture.In conventional coculture systems,however,the in vivo cardiac muscle structure,in which rod-shaped cells are connected end-to-end,is not sustained;instead,irregularly shaped cells spread randomly,resulting in randomly distributed cell junctions.Consequently,contact-mediated cell–cell interactions(e.g.,the electrical triggering signal and the mechanical contraction wave that propagate through MSC–cardiomyocyte junctions)occur randomly.Thus,the data generated on the beneficial effects of MSCs may be irrelevant to in vivo biological processes.In this study,we explored whether cardiomyocyte alignment,the most important phenotype,is relevant to stem cell cardiogenic differentiation.Here,we report(i)the construction of a laser-patterned,biochip-based,stem cell–cardiomyocyte coculture model with controlled cell alignment;and(ii)single-cell-level data on stem cell cardiogenic differentiation under in vivo-like cardiomyocyte alignment conditions. | Zhen Ma Qiuying Liu Huaxiao Yang Raymond B Runyan Carol A Eisenberg Meifeng Xu Thomas K Borg Roger Markwald Yifei Wang Bruce Z Gao | 2013 | Light(Science & Applications)2013，2，1： | 2 |
| 2 | Blockade of CD40 - CD40 ligand Interactions protects against radiation induced pulmonary inflammation and fibrosis 显示文摘 | Adnan A Ying Z Raymond B | 1998 | Clin Immunol Immunopathol1998，89，3： | 1 |
| 3 | Intramolecular energy transfer in pyrene bodipy molecular dyads and triads显示文摘 | Raymond Z Christine G Gilles U | 2005 | Chem Eur J2005，11，24： | 1 |
| 4 | Collecting the Internet AS-Level Topology 显示文摘 | BEICHUAN Z RAYMOND L DANIEL M | 2005 | SIGCOMM Computer Commun Rev2005，35，1： | 1 |
| 5 | Tailoring the properties of boron dipyrromethene dyes with acetylenic functions at the 2,6,8 and 4-B substitution positions显示文摘 | Laure B Gilles U Raymond Z | 2008 | Org Lett2008，10，11： | 1 |
| 6 | NADPH oxidasedependent reactive oxygen species formation required for root hair growth depends on ROP GTPase 显示文摘 | Jones M A Raymond M J Yang Z | 2007 | J Exp Bot2007，，： | 1 |
| 7 | Cardiovascular lesions and skeletal myopathy in mice lacking desmin显示文摘 | Li Z Culocci- Guyon E Pincon- Raymond M | 1996 | Dev Biol1996，175，2： | 1 |
| 8 | Successive epoxy and carbodiimide cross-linking of dermal sheep collagen 显示文摘 | Raymond Z Pieter J D Van Wachem P B | 1999 | Biomaterials1999，20，10： | 1 |
| 9 | Challenges for simultaneous nitrification,denitrification,and phosphorus removal in microbial aggregates:mass transfer limitation and nitrous oxide production显示文摘 | RIKKE L M RAYMOND J Z VALERIO G | 2005 | FEMS Microbiology Ecology2005，，52： | 1 |
| 10 | NADPH oxidase-dependent reactive oxygen species formation required for root hair growth depends on ROP GTPase 显示文摘 | JONES M A RAYMOND M J YANG Z | 2007 | Journal of Experimental Botany2007，58，6： | 1 |
| 11 | 显示文摘 | Raymond Z Pieter J D Van Wachem P B | 1999 | Biomaterials1999，20，10： | 1 |
| 12 | Segmented muhitopic ligands constructed from bipyrimidine,phenanthroline,and terpyridine modules显示文摘 | CHRISTOPHE S | 2004 | Tetrahedron Letters2004，45，： | 1 |
| 13 | Earthquake hydrodynamicpressure on dams显示文摘 | Zee C H Raymond Z | 2006 | Journal of HydraulicEngineering2006，132，11： | 1 |
| 14 | Electricity pro-duction from xylose using a mediator-less microbial fuel cell显示文摘 | HUANG Liping RAYMOND J Z IRINI A | 2008 | Bioresource Technology2008，99，10： | 1 |
| 15 | Modelling the dynamic response of railway track to wheel/rail impact loading显示文摘 | CAI Z RAYMOND G P | 1994 | Structural Engng and Mechanics1994，2，1： | 1 |
| 16 | The impact of nutritional depletion in chronic obstructive pulmonary disease显示文摘 | Foley DO Richard Z | 2001 | Cardiopulmonary Rehabilition2001，21，： | 1 |
| 17 | Integrating green supplychain management into an embryonic eco-industrial develop-ment:a case study of the Guitang Group显示文摘 | QINGHUA Z RAYMOND P C | 2004 | Journal of Clean-er Production2004，12，8910： | 1 |
| 18 | Proton magnetic resonancespectroscopy of the anterior cingulate region in schizophrenia显示文摘 | Raymond FD Ling Z Schuff N | 1997 | Schizophr Res1997，27，1： | 1 |
| 19 | Frequency of the HLA-B * 1502 allele contributing to carbamazepine- induced hypersensitivity reactions in a cohort of Malay- sian epilepsy patients 显示文摘 | THEN S M RANI Z Z RAYMOND A A | 2011 | Asian Pac J Allergy Immunol2011，29，3： | 1 |
| 20 | ChaLlenges for simultaneous nitrification, denitrffation, and phosphorus removal in microbial aggregates: mass franker limitation and nitrous oxide production 显示文摘 | Rikke L M Raymond J Z Valerio G | 2005 | FEMS Microbiology Ecology2005，52，3： | 1 |
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