|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Diversity of microbial plankton across the Three Gorges Dam of the Yangtze River,China显示文摘长江的三个峡水坝(TGD ) ,中国,在世界上是最大的灌溉和水力发电的工程工程之一。效果巨大人造象动物志和 macrophyte 上的 TGD 一样的工程是明显的,主要通过水动力学和流动模式的变化;然而,微生物怎么对如此的变化作出回应,是不太清楚的。这研究被瞄准在不同季节和地点在微生物引起的差异检验差别(在前面并且在 TGD 后面) 。另外,依附粒子、免费生活的社区之间的差别也被检验。在水列在后面并且在 TGD 前面的全部、潜在地活跃的微生物的社区结构与基于 DNA 、基于 RNA 的 16S rRNA 基因被分析在三个不同季节的种系发生的途径。16S rRNA 基因的克隆图书馆从提取 DNA 在扩大以后被准备并且为一些样品,在从提取 rRNA 准备 cDNA 以后。差别在不同季节并且在免费生活、依附粒子的社区之间在地点之间被观察。细菌并且 archaeal 社区比在冬季在夏天是更多样的,由于在夏天的更高滋养的层次和更温暖的温度比在冬季。依附粒子的微生物比免费生活的社区更多样,可能因为在粒子的更高滋养的层次和异构的 geochemical 微型环境。在细菌的社区结构的空间变化被观察,即,在 TGD 后面的水水库(在上游) 比在水坝前面招待了更多样的细菌的人口(下游) ,因为沉积和水从的多样的来源对水库在上游。这些结果在水坝建设影响的河生态系统为我们对环境变化的微生物引起的社区的回答的理解有重要含意。 | Shang Wang Raymond M. Dong Christina Z. Dong Liuqin Huang Hongchen Jiang Yuli Wei Liang Feng Deng Liu Guifang Yang Chuanlun Zhang Hailiang Dong | 2012 | Geoscience Frontiers2012，3，3： | 4 |
| 2 | Drug development in targeting ion channels for brain edema显示文摘Cerebral edema is a pathological hallmark of various central nervous system(CNS)insults,including traumatic brain injury(TBI)and excitotoxic injury such as stroke.Due to the rigidity of the skull,edema-induced increase of intracranial fluid significantly complicates severe CNS injuries by raising intracranial pressure and compromising perfusion.Mortality due to cerebral edema is high.With mortality rates up to 80%in severe cases of stroke,it is the leading cause of death within the first week.Similarly,cerebral edema is devastating for patients of TBI,accounting for up to 50%mortality.Currently,the available treatments for cerebral edema include hypothermia,osmotherapy,and surgery.However,these treatments only address the symptoms and often elicit adverse side effects,potentially in part due to non-specificity.There is an urgent need to identify effective pharmacological treatments for cerebral edema.Currently,ion channels represent the third-largest target class for drug development,but their roles in cerebral edema remain ill-defined.The present review aims to provide an overview of the proposed roles of ion channels and transporters(including aquaporins,SUR1-TRPM4,chloride channels,glucose transporters,and proton-sensitive channels)in mediating cerebral edema in acute ischemic stroke and TBI.We also focus on the pharmacological inhibitors for each target and potential therapeutic strategies that may be further pursued for the treatment of cerebral edema. | Zheng-wei Luo Andrea Ovcjak Raymond Wong Bao-xue Yang Zhong-ping Feng Hong-shuo Sun | 2020 | Acta Pharmacologica Sinica2020，41，10： | 3 |
| 3 | Antioxidant activity, mutagenicity/anti-mutagenicity, and clastogenicity/anti-clastogenicity of lutein from marigold flowers显示文摘 | Mingchen Wang Rong Tsao Shanfeng Zhang Ziming Dong Raymond Yang Jianhua Gong Yingxin Pei | 2006 | Food and Chemical Toxicology2006，，9： | 2 |
| 4 | Laser patterning for the study of MSC cardiogenic differentiation at the single-cell level显示文摘Mesenchymal stem cells(MSCs)have been cited as contributors to heart repair through cardiogenic differentiation and multiple cellular interactions,including the paracrine effect,cell fusion,and mechanical and electrical couplings.Due to heart–muscle complexity,progress in the development of knowledge concerning the role of MSCs in cardiac repair is heavily based on MSC–cardiomyocyte coculture.In conventional coculture systems,however,the in vivo cardiac muscle structure,in which rod-shaped cells are connected end-to-end,is not sustained;instead,irregularly shaped cells spread randomly,resulting in randomly distributed cell junctions.Consequently,contact-mediated cell–cell interactions(e.g.,the electrical triggering signal and the mechanical contraction wave that propagate through MSC–cardiomyocyte junctions)occur randomly.Thus,the data generated on the beneficial effects of MSCs may be irrelevant to in vivo biological processes.In this study,we explored whether cardiomyocyte alignment,the most important phenotype,is relevant to stem cell cardiogenic differentiation.Here,we report(i)the construction of a laser-patterned,biochip-based,stem cell–cardiomyocyte coculture model with controlled cell alignment;and(ii)single-cell-level data on stem cell cardiogenic differentiation under in vivo-like cardiomyocyte alignment conditions. | Zhen Ma Qiuying Liu Huaxiao Yang Raymond B Runyan Carol A Eisenberg Meifeng Xu Thomas K Borg Roger Markwald Yifei Wang Bruce Z Gao | 2013 | Light(Science & Applications)2013，2，1： | 2 |
| 5 | Isoflavone profiles of red clovers and their distribution in different parts harvested at different growing stages 显示文摘 | Rong Tsao Yousef Papadopoulos Raymond Yang | 2006 | Journal of Agricultural and Food Chemistry2006，54，16： | 1 |
| 6 | Expression of the aryl hydrocarbon receptor/transcription factor (AhR) and AhR-regulated CYP1显示文摘 | Anthony F. Trombino Richard I. Near Raymond A. Matulka Shi Yang Laurie J. Hafer Paul A. Toselli Dong W. Kim Adrianne E. Rogers Gail E. Sonenshein David H. Sherr | 2000 | Breast Cancer Research and Treatment2000，，2： | 1 |
| 7 | NADPH oxidasedependent reactive oxygen species formation required for root hair growth depends on ROP GTPase 显示文摘 | Jones M A Raymond M J Yang Z | 2007 | J Exp Bot2007，，： | 1 |
| 8 | Molecular identification and functional expression of porcine Toll-like receptor (TLR) 3 and TLR7显示文摘 | Yongming Sang Jun Yang Chris R. Ross Raymond R.R. Rowland Frank Blecha | 2008 | Veterinary Immunology and Immunopathology2008，，1： | 1 |
| 9 | Opitmization of a new mobile phase to know the complex and real polyphenolic composition: towards a total phenolic index using high-performance liquid chromatography 显示文摘 | Rong Tsao Raymond Yang | 2003 | Journal of Chromatography A2003，1018，： | 1 |
| 10 | Neuroprotective Effects of Polysaccharides from Wolfberry, the Fruits of Lycium barbarum, Against Homocysteine-induced Toxicity in Rat Cortical Neurons显示文摘 | Yuen-Shan Ho Man-Shan Yu Xi-Fei Yang Kwok-Fai So Wai-Hung Yuen Raymond Chuen-Chung Chang | 2010 | Journal of Alzheimer’s Disease2010，，3： | 1 |
| 11 | NADPH oxidase-dependent reactive oxygen species formation required for root hair growth depends on ROP GTPase 显示文摘 | JONES M A RAYMOND M J YANG Z | 2007 | Journal of Experimental Botany2007，58，6： | 1 |
| 12 | Phenolic acid profiles and antioxidant activities of wheat bran extracts and the effect of hydrolysis conditions显示文摘 | Kyung-Hee Kim Rong Tsao Raymond Yang | 2006 | Food Chemistry2006，95，： | 1 |
| 13 | Cyclodextrin complexation: influence on the solubility, stability, and cytotoxicity of camptothecin, an antineoplastic agent显示文摘 | Jichao Kang Vijay Kumar Dong Yang Priyanka Roy Chowdhury Raymond J Hohl | 2002 | European Journal of Pharmaceutical Sciences2002，，2： | 1 |
| 14 | Antitumor efficacy of 26-fluoroepothilone B against human prostate cancer xenografts显示文摘 | Newman R A Yang J Raymond M | 2001 | Cancer Chemother Pharmacol2001，48，4： | 1 |
| 15 | Trends in Prevalence of HIV, Syphilis, Hepatitis C, Hepatitis B, and Sexual Risk Behavior Among Men Who Have Sex With Men: Results of 3 Consecutive Respondent-Driven Sampling Surveys in Beijing, 2004 Through 2006显示文摘 | Xiaoyan Ma Qiyun Zhang Xiong He Weidong Sun Hai Yue Sanny Chen H Fisher Raymond Yang Li Min Xu Hui Du Willi McFarland | 2007 | JAIDS Journal of Acquired Immune Deficiency Syndromes2007，，： | 1 |
| 16 | A Functional Polymorphism in the Epidermal Growth Factor Gene Is Associated With Risk for Hepatocellular Carcinoma显示文摘 | Barham K. Abu Dayyeh May Yang Bryan C. Fuchs Daniel L. Karl Suguru Yamada John J. Sninsky Thomas R. O’Brien Jules L. Dienstag Kenneth K. Tanabe Raymond T. Chung | 2011 | Gastroenterology2011，，1： | 1 |
| 17 | l Polyphenolic profiles in eightapple cuhivars using hightperformance liquid chromatography(HPLC)显示文摘 | Rong Tsao Raymond Yang J Christopher Young et a | 2003 | Agric Food Chem2003，51，： | 1 |
| 18 | Phenolic acid profiles and antioxidant activities of wheat bran extracts and the effect of hydrolysis conditions显示文摘 | Kyung-Hee Kim Rong Tsao Raymond Yang | 2006 | Food Chemistry2006，95，： | 1 |
| 19 | Carbon dioxide reforming of methane to synthesis gas over Ni-MCM-41 catalysts显示文摘 | Liu Dapeng Lau Raymond Borgna Armando Yang Yanhui | 2009 | Applied Catalysis A: General2009，358，： | 1 |
| 20 | Hierarchical Modulation with Vector Rotation for E-MBMS Transmission in LTE Systems显示文摘 | Hui Zhao Xiaoping Zhou Yunchuan Yang Wenbo Wang Raymond Kwan | 2010 | Journal of Electrical and Computer Engineering2010，，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员