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您的检索式：作者名="Raymond Ko"
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| 1 | ^(68)Ga-PSMA PET/CT versus CT and bone scan for investigation of PSA failure post radical prostatectomy显示文摘Objective:To evaluate the use of Gallium-68 prostate-specific membrane antigen positron emission tomography/computed tomography(^(68)Ga-PSMA PET/CT),compared with conventional CT abdomen/pelvis(CTAP)and whole body single photon emission CT bone scan(BS),for detection of local or distant metastasis following biochemical failure/recurrence in post-prostatectomy patients.Methods:We conducted a review of our prospectively maintained,institutional database to identify 384 patients with post-prostatectomy biochemical failure/recurrence who underwent PSMA PET/CT,CTAP and BS from February 2015 to August 2017 in Nepean Hospital,tertiary referral centre.The results of the three imaging modalities were analysed for their ability to detect local recurrence and distant metastases.PSMA PET/CT and CTAP imaging were separately performed on the same day and the BS was performed within several days(mostly in 24 h).Difference in detection rates was determined between the modalities and the Chi square test was used to determine significance.Results:A total of 384 patients were identified with a median prostate-specific antigen(PSA)of 0.465 ng/mL(interquartile range =0.19-2.00 ng/mL).Overall,PSMA PET/CT was positive for 245(63.8%)patients whereas CTAP and BS were positive in 174 patients(45.3%).A total of 98 patients(25.5%)had local or distant metastasis detected on PSMA only,while 20 patients(5.2%)had recurrences detected on CTAP but not on PSMA PET/CT.Conclusion:The use of PSMA PET/CT has a higher detection rate of predicted local or distant metastasis compared to CTAP and BS in the staging of patients with biochemical recurrences after radical prostatectomy. | Yuigi Yuminaga Chris Rothe Jonathan Kam Kieran Beattie Mohan Arianayagam Chuong Bui Bertram Canagasingham Richard Ferguson Mohamed Khadra Raymond Ko Ken Le Diep Nguyen Celi Varol Matthew Winter | 2021 | Asian Journal of Urology2021，8，2： | 1 |
| 2 | GM604 regulates developmental neurogenesis pathways and the expression of genes associated with amyotrophic lateral sclerosis显示文摘Background:Amyotrophic lateral sclerosis(ALS)is currently an incurable disease without highly effective pharmacological treatments.The peptide drug GM604(GM6 or Alirinetide)was developed as a candidate ALS therapy,which has demonstrated safety and good drug-like properties with a favorable pharmacokinetic profile.GM6 is hypothesized to bolster neuron survival through the multi-target regulation of developmental pathways,but mechanisms of action are not fully understood.Methods:This study used RNA-seq to evaluate transcriptome responses in SH-SY5Y neuroblastoma cells following GM6 treatment(6,24 and 48 h).Results:We identified 2867 protein-coding genes with expression significantly altered by GM6(FDR<0.10).Early(6 h)responses included up-regulation of Notch and hedgehog signaling components,with increased expression of developmental genes mediating neurogenesis and axon growth.Prolonged GM6 treatment(24 and 48 h)altered the expression of genes contributing to cell adhesion and the extracellular matrix.GM6 further down-regulated the expression of genes associated with mitochondria,inflammatory responses,mRNA processing and chromatin organization.GM6-increased genes were located near GC-rich motifs interacting with C2H2 zinc finger transcription factors,whereas GM6-decreased genes were located near AT-rich motifs associated with helix-turn-helix homeodomain factors.Such motifs interacted with a diverse network of transcription factors encoded by GM6-regulated genes(STAT3,HOXD11,HES7,GLI1).We identified 77 ALS-associated genes with expression significantly altered by GM6 treatment(FDR<0.10),which were known to function in neurogenesis,axon guidance and the intrinsic apoptosis pathway.Conclusions:Our findings support the hypothesis that GM6 acts through developmental-stage pathways to influence neuron survival.Gene expression responses were consistent with neurotrophic effects,ECM modulation,and activation of the Notch and hedgehog neurodevelopmental pathways.This multifaceted mechanism of action is unique among existing ALS drug candidates and may be applicable to multiple neurodegenerative diseases. | William R.Swindell Krzysztof Bojanowski Mark S.Kindy Raymond M.W.Chau Dorothy Ko | 2018 | Translational Neurodegeneration2018，7，1： | 0 |
| 3 | 先进的前道CMP设备及整合解决方法显示文摘概述了未来IC器件可采用的前道CMP设备及整合解决方法的巨大进展。为提高设备的可用性和生产线的运作效率,在一台设备上采用多用途的整合解决方法。而且,对这些方法与下一代无磨料网膜抛光设备的能力进行了比较。未来数代器件要求的CMP工艺技术包括先进的抛光头、先进的现场终点系统、多平台、多抛光头结构。与下一代消耗品(单独硬抛光垫、高平面性磨料、无磨料抛光等)结合,能使直接抛光浅沟槽隔离(STI)工艺方法满足0.18μm乃至更小特征尺寸的器件要求。采用新型多步工艺进行了多晶硅CMP。先进的多晶硅金属介质(PMD)抛光工艺展示了更长寿命的抛光垫和更高的金刚石盘片生产效率和更强的设备可用性。这些工艺技术已全部成功地使用在生产线,并正在生产中进行测试。 | Raymond R.Jin Sen-Hou Ko Benjamin A.Bonner Shijian Li Thomas H.Osterheld Kathleen A.Perry | 2003 | 电子工业专用设备2003，32，6： | 0 |
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