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| 1 | Dietary supplementation of Bacillus subtilis influenced intestinal health of weaned pigs experimentally infected with a pathogenic E. coli显示文摘Background: There is growing evidence to support the beneficial effects of supplementing direct-fed microbials(DFM) on performance, health status, and immune responses of weaned pigs. Therefore, the objective of this study was to investigate dietary supplementation of Bacillus subtilis(DSM 25841) on growth performance, diarrhea, gut permeability and immunity of weaned pigs experimentally infected with a pathogenic F-18 Escherichia coli(E. coli).Results: The F18 E. coli infection reduced(P < 0.05) growth performance and intestinal villi height, whereas increased(P < 0.05) diarrhea and transcellular and paracellular permeability in the jejunum compared with non-challenged control. Supplementation of Bacillus subtilis linearly enhanced average daily gain of E. coli infected pigs from d 0 to 5 post-inoculation(PI)(P < 0.05) and d 0 to 11 PI(P = 0.058). Supplementation of high dose of Bacillus subtilis reduced(P < 0.05) both transcellular and paracellular permeability on d 5 and d11 PI compared with the E. coli infected pigs fed with control diet. E. coli infection up-regulated(P < 0.05)the m RNA expression of SLC5 A10(soluble carrier family 5 member 10) and MUC2(mucin 2) on d 5 PI, but down-regulated(P < 0.05) expression of SLC5 A10, MUC2, and CLDN1 on d 11 PI in jejunal mucosa when pigs were fed with the control diet. Supplementation of Bacillus subtilis linearly up-regulated(P < 0.05) the m RNA expression of CFTR and ZO1 on d 5 PI and SLC5 A10 and MUC2 on d 11 PI in jejunal mucosa of E. coli infected pigs. In addition, E. coli infection increased(P < 0.05) the m RNA expression of several immune genes(IL1 A, IL1 B, and IL7 on d 5 PI, and IL1 B, IL6, IL7, and TNF on d 11 PI) in the ileal mucosa of weaned pigs. Inclusion of Bacillus subtilis to control diet linearly down-regulated gene expression of IL1 A on d 5 PI(P = 0.07) and IL6 on d 11 PI(P < 0.05) in ileal mucosa of E. coli infected pigs.Conclusions: Supplementation of Bacillus subtilis(DSM 25841) enhanced growth rate and improved gut barrier function of weaned pigs experimentally infected with a pathogenic E. coli. | Kwangwook Kim Yijie He Xia Xiong Amy Ehrlich Xunde Li Helen Raybould Edward R.Atwill Elizabeth A.Maga Jens JΦrgensen Yanhong Liu | 2019 | Journal of Animal Science and Biotechnology2019，10，4： | 3 |
| 2 | Gut microbiota,epithelial function and derange- ments in obesity显示文摘 | Raybould HE | 2012 | J Physiol2012，590，3： | 1 |
| 3 | Vagal afferent ne- urons in high fat diet-induced obesity;intestinal microflora,gut inflammation and cholecystokinin 显示文摘 | de Lartigue G de La Serre CB Raybould HE | 2011 | Physiol Behav2011，105，1： | 1 |
| 4 | Gastric emptying of solids but not liquids is decreased in rats with chronic renal failure显示文摘 | Raybould HE Plourde V Vittel T | 1994 | Dig Dis1994，39，8： | 1 |
| 5 | Expression of 5 HT3 receptors by extrinsic duodenal afferents contribute to intestinal inhibition of gastric emptying显示文摘 | Raybould HE Glatzle J Robin C | 2003 | Am J Physiol Gastrointest Liver Physiol2003，284，： | 1 |
| 6 | Expression of 5-HT3 receptors by extrinsic duodenal afferents contribute to intestinal inhibition of gastric emptying显示文摘 | Raybould HE Glatzle J Robin C | 2003 | Am J Physiol Gastrointest Liver Physiol2003，284，： | 1 |
| 7 | Deletion of leptin signaling in vagal afferent neurons results in hyperphagia and o- besity显示文摘 | De Lartigue G Ronveaux CC Raybould HE | 2014 | Mol Metab2014，3，6： | 1 |
| 8 | Deletion of leptin signaling in vagal afferent neurons results in hy- perphagia and obesity显示文摘 | De Lartigue G Ronveaux CC Raybould HE | 2014 | Mol Metab2014，3，6： | 1 |
| 9 | Role of calcitonin gene-related peptide in gastric hyperemic response to intragastric eapsaiein 显示文摘 | Li DS Raybould HE Quintero E | 1991 | Am J Physiol1991，261，4： | 1 |
| 10 | Role of visceral afferent mechanisms in functional bowel disorders显示文摘 | Mayer EA Raybould HE | 1990 | Gastroenterology1990，99，6： | 1 |
| 11 | Calcitonin gene-related peptide mediates the gastric hyperemic response to acid back diffusion显示文摘 | Raybould HE Ouintero E | 1992 | Gastroenterology1992，102，11： | 1 |
| 12 | Visceral perception:sensory transduetion in visceral afferents and nutrients 显示文摘 | Raybould HE | 2002 | Gut2002，51，1： | 1 |
| 13 | Activation of hindbrain neurons in response to gastrointestinal lipid is attenuated by high fat, high energy diets in mice prone to diet-induced obesity 显示文摘 | Donovan M J Paulino G Raybould HE | 2009 | Brain Res2009，1248，： | 1 |
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