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125篇 您的检索式：作者名="Rauvala"

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	题名	作者	年代	出处	被引量
1	Inhibition and enhancement of neural regeneration by chondroitin sulfate proteoglycans显示文摘The current dogma in neural regeneration research implies that chondroitin sulfate proteoglycans(CSPGs) inhibit plasticity and regeneration in the adult central nervous system(CNS). We argue that the role of the CSPGs can be reversed from inhibition to activation by developmentally expressed CSPG-binding factors. Heparin-binding growth-associated molecule(HB-GAM; also designated as pleiotrophin) has been studied as a candidate molecule that might modulate the role of CSPG matrices in plasticity and regeneration. Studies in vitro show that in the presence of soluble HB-GAM chondroitin sulfate(CS) chains of CSPGs display an enhancing effect on neurite outgrowth. Based on the in vitro studies, we suggest a model according to which the HB-GAM/CS complex binds to the neuron surface receptor glypican-2, which induces neurite growth. Furthermore, HB-GAM masks the CS binding sites of the neurite outgrowth inhibiting receptor protein tyrosine phosphatase sigma(PTPσ), which may contribute to the HB-GAM-induced regenerative effect. In vivo studies using two-photon imaging after local HB-GAM injection into prick-injury of the cerebral cortex reveal regeneration of dendrites that has not been previously demonstrated after injuries of the mammalian nervous system. In the spinal cord, two-photon imaging displays HB-GAM-induced axonal regeneration. Studies on the HB-GAM/CS mechanism in vitro and in vivo are expected to pave the way for drug development for injuries of brain and spinal cord.	Heikki Rauvala Mikhail Paveliev Juha Kuja-Panula Natalia Kulesskaya	2017	Neural Regeneration Research2017，12，5：	4
2	Persistent elevation of high mobility group box-1 protein (HMGB1) in patients with severe sepsis and septic shock显示文摘	Jonas Sundén-Cullberg Anna Norrby-Teglund Ari Rouhiainen Heikki Rauvala Gunilla Herman Kevin J. Tracey Martin L. Lee Jan Andersson Leif Tokics Carl Johan Treutiger	2005	Critical Care Medicine2005，，3：	2
3	RAGE as a receptor of HMGB1(Amphoterin):roles in health and disease显示文摘	Rauvala H Rouhiainen A	2007	Curr Mol Med2007，7，8：	1
4	Efferent targets of osseous CGRP-immmunoreactive nerve fiber before and after bone destruction in adjuvant arthritic rat;an ultra morphological study on their terminal-target relations显示文摘	Imai S Rauvala H Konttinen YT	1997	J Bone Miner Res1997，12，：	1
5	RAGE as a receptor of HMGB1 (Amphoterin): roles in health and disease显示文摘	Rauvala H Rouhiainen A	2007	Curt Mol Med2007，7，8：	1
6	Gelatinases A and B (MMP-2 and MMP-9) in endometrial cancer-MMP-9 correlates to the grade and the stage显示文摘	Aglund K Rauvala M Puistola U	2004	Gynecol Oncol2004，94，3：	1
7	RAGE as areceptor of HMGB1 (Amphoterin) : roles in health and disease显示文摘	Rauvala H Rouhiainen A	2007	Curr Mol Med2007，7，8：	1
8	HB-GAM/Pleiotrophin and midkine are differently expressed and distributed during retinoic acid-induced neural differentiation of P19 cells 显示文摘	Carvalho BN Raulais D Rauvala H	2003	Growth Factors2003，21，34：	1
9	Amphoterin as an extracellular regulator of cell motility:from discovery to disease显示文摘	Huttunen HJ Rauvala H	2004	J Intern Med2004，255，3：	1
10	Receptor for advanced glyca- tion end products(RAGE)-mediated neurite outgrowth and activa- tion of NF-kB require the cytoplasmic domain of the receptor but different downstream signaling pathways 显示文摘	Huttunen H J Fages C Rauvala H	1999	J Biol Chem1999，274，19：	1
11	Physiological and pathophysiological outcomes of the interactions of HMGB1 with cell surface receptors 显示文摘	Rauvala H Rouhiainen A	2010	Biochim Biophys Acta2010，1799，12：	1
12	Receptor for advanced glycation end products (RAGE) signaling induces CREB-dependent chromogranin expression during neuronal differentiation显示文摘	Huttunen HJ Kuja-Panula J Rauvala H	2002	J Biol Chem2002，277，38：	1
13	Low molecular weight high-mannose type glycans in a secreted protein of the filamentous fungus显示文摘	Salovuori I Makarow M Rauvala H	1987	Bio/Technology1987，5，：	1
14	Impaired behavioural flexi- bility and memory i n mice lacking GDNF family receptor al- pha2 显示文摘	Vikar V Rossi J Rauvala H	2004	Eur Neurosci2004，20，1：	1
15	Molecular cloning of the 18-kDa growth-associated protein of developing brain 显示文摘	MERENMIES J RAUVALA H	1990	J Biol Chem1990，265，16：	1
16	Gelatinases A and B (MMP-2 and MMPo9) in endometrial cancer--MMP-9 correlates to the grade and the stage 显示文摘	Aglund K Rauvala M Puistola U	2004	Gynecol Oncol2004，94，3：	1
17	Gelatinases A and B (MMP-2 and MMP-9) in endometrial cancer-MMP-9 correlates to the grade and the stage显示文摘	Aglund K Rauvala M Puistola U	2004	Gynecol Oncol2004，94，3：	1
18	Impaired behavioural flexibil- ity and memory in mice lacking GDNF family receptor alpha2 显示文摘	Voikar V Rossi J Rauvala H	2004	Eur Neurosci2004，20，1：	1
19	Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-kappaB require the cytoplasmic domain of the receptor but different downstream signaling pathways显示文摘	Huttunen HJ Fages C Rauvala H	1999	J Biol Chem1999，274，19：	1
20	Gelatinases A and B (MMP-2 and MMP-9) in endometrial cancer--MMP-9 correlates to the grade and the stage显示文摘	Aglund K Rauvala M Puistola U l	2004	Gynecol Oncol2004，94，：	1

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