|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 在良性的胆汁的阻塞的 choledochoduodenostomy 的长期的结果显示文摘 AIM:To determine the long-term results of choledochodudenostomy in patients with benign billiary obstruction.METHODS:This prospective study was conducted at Sheri Kashmir Institute of Medical Sciences Srinagar Kashmir,India over a period of 10 years from January 1997 to December 2007.The total number of patients who underwent choledochoduodenostomy during this period was 270.On the basis of etiology of biliary tract obstruction,patients were divided into a calculus group,an oriental cholangiohepatitis group,a benign biliary stricture group and others.Patients were followed for a variable period of 13 mo to 15 years.RESULTS:Choledochoduodenostomy(CDD) with duodenotomy was performend in four patients.CDD with removal of T-tube,CDD with left hepatic lobectomy and CDD with removal of intra biliary ruptured hydatid was performed in three patients each.In the remaining patients only CDD was performed.Immediate post operative complications were seen in 63(23%) patients,while long-term complications were seen in 28(11%) patients,which were statistically significant.Three patients died during hospitalization while four patients died in the late post-operative period.CONCLUSION:Our conclusion is that CDD is safe and produces good long term results when a permanent biliary drainage procedure is required. | Ajaz A Malik Shiraz A Rather Shams UL Bari Khursheed Alam Wani | 2012 | World Journal of Gastrointestinal Surgery2012，4，2： | 7 |
| 2 | Portal biliopathy显示文摘Portal biliopathy refers to cholangiographic abnormalities which occur in patients with portal cavernoma. These changes occur as a result of pressure on bile ducts from bridging tortuous paracholedochal, epicholedochal and cholecystic veins. Bile duct ischemia may occur due prolonged venous pressure effect or result from insufficient blood supply. In addition, encasement of ducts may occur due fibrotic cavernoma. Majority of patients are asymptomatic. Portal biliopathy is a progressive disease and patients who have long standing disease and more severe bile duct abnormalities present with recurrent episodes of biliary pain, cholangitis and cholestasis. Serum chemistry, ultrasound with color Doppler imaging, magnetic resonance imaging with magnetic resonance cholangiopancreatography and magnetic resonance portovenography are modalities of choice for evaluation of portal biliopathy. Endoscopic retrograde cholangiography being an invasive procedure is indicated for endotherapy only. Management of portal biliopathy is done in a stepwise manner. First, endotherapy is done for dilation of biliary strictures, placement of biliary stents to facilitate drainage and removal of bile duct calculi. Next portal venous pressure is reduced by formation of surgical porto-systemic shunt or transjugular intrahepatic portosystemic shunt. This causes significant resolution of biliary changes. Patients who persist with biliary symptoms and bile duct changes may benefit from surgical biliary drainage procedures(hepaticojejunostomy or choledechoduodenostomy). | mohammad s khuroo ajaz a rather naira s khuroo mehnaaz s khuroo | 2016 | World Journal of Gastroenterology2016，22，35： | 6 |
| 3 | 利拉鲁肽与格列美脲在单药治疗2型糖尿病中的比较(LEAD-3 Mono):一项随机、双盲、平行分组、52周的Ⅲ期临床试验显示文摘背景 2型糖尿病新的治疗策略,需要针对胰岛素-葡萄糖的相互作用,且同时要降低体重增加和发生低血糖的风险。本文作者旨在调查利拉鲁肽单药治疗2型糖尿病的安全性与有效性。
方法 采用双盲、双模拟、治疗一对照、平行分组的研究,746例早期2型糖尿病患者被随机分配到1次/d利拉鲁肽组[1.2mg(n=251)或1.8mg(n=247)]或格列美脲8mg组(n=248),分别治疗52周。主要结局指标为糖化血红蛋白(HbA1c)的改变程度。采用意向性治疗进行分析。该试验在ClinicalTrials.gov网站的注册编码为NTC00294723.
结果52周时,格列美脲组HbA,。下降了0.51%(s=1.20),而利拉鲁肽1.2mg组下降了0.84%(s=1.23)(差值为-0.33.95%CI-0.53~-0.13;P=0.0014),利拉鲁肽1.8mg组下降了1.14%(S=1.24)(差值为-062,95%CI-0.83—-0.42;P〈0.0001)。利拉鲁肽1.2mg组和1.8mg组各有5例和1例患者因呕吐停止治疗,而格列美脲组未出现这种情况。
结论 利拉鲁肽作为2型糖尿病的初始治疗药物安全有效,与格列美脲相比更能降低HbA1c以及体重、血压和低血糖的发生率。 | Alan Garber Robert Henry Robert Rather Pedro A Garcia-Hernandez Hiromi Rodriguez-Pattzi Israel Olvero-Alvarez Paula M Hale, Milan Zdravkovic Bruce Bode 邓斌(译) | 2009 | 世界临床医学2009，，6： | 5 |
| 4 | Hepatobiliary and pancreatic ascariasis显示文摘Hepatobiliary and pancreatic ascariasis(HPA) was described as a clinical entity from Kashmir,India in 1985. HPA is caused by invasion and migration of nematode,Ascaris lumbricoides,in to the biliary tract and pancreatic duct. Patients present with biliary colic,cholangitis,cholecystitis,hepatic abscesses and acute pancreatitis. Ascarides traverse the ducts repeatedly,get trapped and die,leading to formation of hepatolithiasis. HPA is ubiquitous in endemic regions and in Kashmir,one such region,HPA is the etiological factor for 36.7%,23%,14.5% and 12.5% of all biliary diseases,acute pancreatitis,liver abscesses and biliary lithiasis respectively. Ultrasonography is an excellent diagnostic tool in visualizing worms in gut lumen and ductal system. The rational treatment for HPA is to give appropriate treatment for clinical syndromes along with effective anthelmintic therapy. Endotherapy in HPA is indicated if patients continue to have symptoms on medical therapy or when worms do not move out of ductal lumen by 3 wk or die within the ducts. The worms can be removed from the ductal system in most of the patients and such patients get regression of symptoms of hepatobiliary and pancreatic disease. | Mohammad S Khuroo Ajaz A Rather Naira S Khuroo Mehnaaz S Khuroo | 2016 | World Journal of Gastroenterology2016，22，33： | 4 |
| 5 | Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3Mono) : a randomized, 52-week, phase III, double-blind,parallel-treatment trial 显示文摘 | Garber A Henry R Rather R | 2009 | J Lancet2009，373，9662： | 1 |
| 6 | Fewer than 12 lymph nodes can be expected in a surgical specimen after high-dose chemoradiation therapy for rectal cancer显示文摘 | M(a)rks JH Valsdottir EB Rather AA | 2010 | Dis Colon Rectum2010，53，7： | 1 |
| 7 | Human demodex mite: the versatile mite of dermatological importance显示文摘 | Rather P A Hassan I | 2014 | Indian J Dermatol2014，59，1： | 1 |
| 8 | Connective tissue growth factor expression hints at aggressive nature of colorectal cancer显示文摘BACKGROUND Connective tissue growth factor(CTGF)is a mediator of transforming growth factor-beta signaling and plays a key role in connective tissue remodeling,inflammatory processes and fibrosis in various illnesses including cancer.AIM To investigate the role of CTGF in colorectal cancer(CRC)progression and to compare the CTGF expression with different clinicopathological parameters.METHODS Real-time polymerase chain reaction,immunohistochemistry and Western blotting was performed to evaluate the CTGF expression and the results were statistically analyzed against the clinicopathological variables of patient data using STATA software version 16.RESULTS CTGF expression levels in tumor specimens were significantly higher than their paired normal specimens.The higher protein expression levels showed a significant association with smoking,staging,tumor grade,invasion depth,necrosis of tumor tissue,and both lymphovascular and perineural invasion.As per the cox regression model and classification tree analysis,tumor-nodemetastasis stage and perineural invasion were important predictors for CTGF expression and prognosis of CRC patients.Survival analysis indicated that CTGF overexpression was associated with poorer overall and disease-free survival.CONCLUSION Expression of CTGF was increased in CRC and was linked with poor overall and disease-free survival of CRC patients.These findings support prior observations and thus CTGF may be a possible prognostic marker in CRC. | Ishrat Parveiz Bhat Tahseen Bilal Rather Irfan Maqbool Gowhar Rashid Kulsum Akhtar Gulzar A Bhat Fazl Q Parray Besina Syed Ishrat Younas Khan Mohsin Kazi Muhammad D Hussain Mudassar Syed | 2022 | World Journal of Gastroenterology2022，28，5： | 1 |
| 9 | LEAD-3 (Mono) Study Group: Liraglutide versus glimepiride monotherapy for type 2 diabetes ( LEAD-3 Mono ) : a randomised, 52-week, phase III, double-blind, parallehreatment trial 显示文摘 | Garber A Henry R Rather R | 2009 | Lancet2009，373，： | 1 |
| 10 | An exploration of pender' s health promotion model using LISREL显示文摘 | Johnson J L Rather P A Bottorff J | 1993 | Nursing Re- search1993，42，3： | 1 |
| 11 | Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes显示文摘 | DeFronzo R A Rather R E Hart J | 2005 | Diabetes Care2005，28，5： | 1 |
| 12 | Mixed micellization and interfacial properties of dodecyhrimethylammouium bromide and tetraethy|eneglycol mono - n - dodecyl ether in absence and presence of sodium propiouate显示文摘 | Dar A A Chatterjee B Rather G M | 2006 | J Colloid lntesrace Scl2006，298，1： | 1 |
| 13 | Mixed micelle formation and solubilization behavior toward polycyclic aromatic hydrocarbons of binary and teman: cationic-nonionic surfactant mixtures显示文摘 | Dar A A Rather G M Das A R | 2007 | J Phys Chem B2007，111，12： | 1 |
| 14 | The effect of etomidate on adrenal function in critical illness:a systematic review显示文摘 | Albert SG Ariyan S Rather A | 2011 | Intensive Care Med2011，37，6： | 1 |
| 15 | Effect of surfac treat mixing on partitioning of model hydrophobic drug, naproxen, between aqueous and micellar phases显示文摘 | Bhat P A Rather G M Dar A A | 2009 | J Plays Chem B2009，113，： | 1 |
| 16 | The effect of etomidate on adrenalfunction in critical illness:a systematic review显示文摘 | Albert SG Ariyan S Rather A | 2011 | Intensive CareMed2011，37，6： | 1 |
| 17 | Liraglutide versus glimepiride monotherapy for type 2 diabetes(LEAD-3 Mono): a randomised, 52- week, phase Ⅲ, double- blind, parallel-treatment trial显示文摘 | Oarber A Henry R Rather R | 2009 | Lancet2009，373，9662： | 1 |
| 18 | Synthesis and e- valuation of novel 2-substituted-quinazolin-d (3H) -ones as potent analgesic and anti-inflammatory agents 显示文摘 | Rather B A Raj T Reddy A | 2010 | Arch Pharm2010，343，2： | 1 |
| 19 | Effect of sodium butanoate and sodium hexanoate on micelle formation of modal cationic-notrionic and anionic- nonionic suffactant mixtures显示文摘 | Jan M Dar A A Rather G M | 2009 | Colloids and Surfaces A: Physicochem Eng Aspects2009，335，： | 1 |
| 20 | Design and con- structian of molecular assemblies with large second-or- der optical nonlinearities quantum chemical aspect 显示文摘 | Kanis D R Rather M A Marks T | 1994 | J Chem Rev1994，94，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员