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| 1 | Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype显示文摘AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA. Immunohistochemistry was performed to detect intestinal dendritic cells (DCs) within the colonic tissue, and the effect of the calcitriol analog on DCs was investigated. RESULTS: Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. In animals with acute DSS colitis, down- regulation of colonic inflammation was associated with a dramatic reduction in the secretion of the proinflammatory cytokine interferon (IFN)-γ and a significant increase in intereleukin (IL)-10 by MLN cells. Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. Lower numbers of infiltrating activated CD11c+ DCs were found in the colon in ZK191784-treated mice with acute DSScolitis, and secretion of proinflammatory cytokines by primary mucosal DCs was inhibited in the presence of the calcitriol analog. CONCLUSION: The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs. | Ulrike G Strauch Florian Obermeier Nicole Grunwald Nadja Dunger Heiko C Rath Jürgen Schlmerich A Steinmeyer U Zügel HH Herfarth | 2007 | World Journal of Gastroenterology2007，13，48： | 4 |
| 2 | Changes in hepatic hemodynamics due to primary liver tumours显示文摘 | Jakab F Rath Z Schmal F | 1996 | HPB Surg1996，9，4： | 1 |
| 3 | Extraction denaturation and hydrophobie properties of rice flour proteins 显示文摘 | Ju Z Y Hettiarachchy Rath N | 2001 | Jourual of Food Science2001，66，2： | 1 |
| 4 | A new method to measure portal venous and hepatic arterial blood flow in patients intraoperatively 显示文摘 | Jakab F Rath Z Schmal F | 1996 | HPB Surg1996，9，4： | 1 |
| 5 | Extraction, denaturation and hydrophobic properties of rice flour proteins 显示文摘 | JU Z Y HETFIARACHCHY N S RATH N | 2001 | Food Chemistry and Toxicology2001，66，2： | 1 |
| 6 | Extraction, denaturation and hydrophobic properties of rice flour proteins显示文摘 | Ju Z Y Hettlarachchy N S Rath N | 2001 | Journal of Food Science2001，66，2： | 1 |
| 7 | Extraction, denaturation and hydrophobic properties of rice flour proteins显示文摘 | Z Y JU N S Hettiarachchy N Rath | 2001 | Journal of Food Science2001，66，2： | 1 |
| 8 | 查看详情显示文摘 | Jimenez Z R Rubinelli F A Rath J K Schropp R E I | | 0，，： | 1 |
| 9 | Extraction, denaturation and hydrophobic properties of rice flour proteins显示文摘 | JU Z Y HETTIARACHY N S RATH N | 2001 | Journal of Food Science2001，66，2： | 1 |
| 10 | Extraction, denaturationand hydrophobic properties of rice flour proteins显示文摘 | JU Z Y HETTARACHCHY N S RATH N | 2001 | Journal of FoodScience2001，66，2： | 1 |
| 11 | Extraction,denaturation and hydrophobic properties of rice flour proteins显示文摘 | Ju Z Y Hettlarachchy N S Rath N | 2001 | Journal of Food Science2001，66，2： | 1 |
| 12 | Extraction,denaturation and hydrophobic properties of rice flour proteins显示文摘 | Ju Z Y Hettiarachchy N S Rath N | 2001 | Journal of Food Science2001，66，2： | 1 |
| 13 | Spontaneous spinal epidural haematoma: a rare cause of quadriplegia in the post-partum period显示文摘 | Bose S Ali Z Rath GP | 2007 | Br J Anaesth2007，99，6： | 1 |
| 14 | Bone characteristics of 16 wk-old-turkeys subjected to different dietary supplements and simulated stress 显示文摘 | Zhou Z L Rath N C Huff G R | 2011 | International Journal of Poultry Science2011，10，5： | 1 |
| 15 | A newmethod tomeasure portal venous and hepatic arterial blood flow in patients intraoperatively 显示文摘 | Jakab F Rath Z Schmal F | 1996 | HPB Surg1996，9，4： | 1 |
| 16 | Extraction, denaturationand hydrophobic properties of rice flour proteins 显示文摘 | Ju Z Y Hettiarachchy N S Rath N | 2001 | Journal ofFood Science2001，66，2： | 1 |
| 17 | Extraction Denaturation and Hydrophobic Properties of Rice flour Proteins显示文摘 | Ju Z Y Hettiarachchy Rath N | 2001 | Journal of Food Science2001，，2： | 1 |
| 18 | Water Management Stud- ies in PEM Fuel Cells显示文摘 | Lua Z Kandlikar S G Rath C | 2009 | International Journal of Hydrogen En- ergy2009，34，： | 1 |
| 19 | Comparison of optic nerve head topography findings in eyes with non-arteritic anterior ischemic optic neuropathy and eyes with glaucoma显示文摘 | Horowitz J Fishelzon-Arev T Rath E Z | 2010 | Graefes Arch Clin Exp Ophthalmol2010，248，6： | 1 |
| 20 | The use of modified Baylor score in the prediction of rebleeding in peptic ulcer hemorrhage显示文摘 | ONDREJKA P SUGAR I RATH Z | 1997 | Acta Chir Hung1997，36，14： | 1 |
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