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| 1 | Molecular characterization of cyanobacterial diversity in Lake Gregory, Sri Lanka显示文摘Eutrophication or the process of nutrient enrichment of stagnant waters due to excessive use of fertilizer is becoming a critical issue worldwide. Lake Gregory, an artificial lake situated in Nuwara Eliya, Sri Lanka was once a very attractive landscape feature and recreational area attracting a large number of visitors. Rapid urbanization in surrounding areas and the consequent intensification of agricultural and industrial activities led to eutrophication and siltation in the lake. Present study was conducted to detect cyanobacterial diversity and their ability to produce hepatotoxic microcystins using polymerase chain reaction (PCR)-based techniques. Twenty five water samples (surface and bottom) were collected from the lake and total nitrogen and total carbon were estimated. Cyanobacterial cultures were grown in appropriate media and microscopic observations were used to determine the morphological diversity of cyanobacteria isolated from different sites. Genomic DNA was isolated and purified from cyanobacteria using Boom's method. DNA samples were analyzed by PCR with oligonucleotide primers for 16S rRNA gene and mcyA gene of the operon that encodes a microcystin synthetase. The 16S rRNA gene sequences revealed the presences of cyanobacteria belong to Synechococcus sp., Microcystis aeruginosa, Calothrix sp., Leptolyngbya sp., Limnothrix sp., order Oscillatoriales and order Chroococcales. The sequences obtained from this study were deposited in the database under the accession numbers (GenBank: GU368104-GU368116). PCR amplification of mcyA primers indicated the potential for toxin formation of isolated M. aeruginosa from Lake Gregory. This preliminary study shows that the Lake Gregory is under the potential risk of cyanobacterial toxicity. Clearly more work is needed to extend this finding and clarify if other cyanobacterial isolates have genetic potential to produce microcystin since this lake is utilized for recreational activities. | Dhammika MAGANA-ARACHCHI Rasika WANIGATUNGE Madhushankha LIYANAGE | 2011 | Chinese Journal of Oceanology and Limnology2011，29，4： | 3 |
| 2 | Understanding the molecular mechanisms of cancer prevention by dietary phytochemicals:From experimental models to clinical trials显示文摘Chemoprevention is one of the cancer prevention approaches wherein natural/synthetic agent(s) are prescribed with the aim to delay or disrupt multiple pathways and processes involved at multiple steps, i.e., initiation, promotion, and progression of cancer. Amongst environmental chemopreventive compounds, diet/beverage-derived components are under evaluation, because of their long history of exposure to humans, high tolerability, low toxicity, and reported biological activities. This compilation briefly covers and compares the available evidence on chemopreventive efficacy and probable mechanism of chemoprevention by selected dietary phytochemicals(capsaicin, curcumin, diallyl sulphide, genistein, green/black tea polyphenols, indoles, lycopene, phenethyl isocyanate, resveratrol, retinoids and tocopherols) in experimental systems and clinical trials. All the dietary phytochemicals covered in this review have demonstrated chemopreventive efficacy against spontaneous or carcinogen-induced experimental tumors and/or associated biomarkers and processes in rodents at several organ sites. The observed anti-initiating, anti-promoting and anti-progression activity of dietary phytochemicals in carcinogen-induced experimental models involve phytochemical-mediated redox changes, modulation of enzymes and signaling kinases resulting to effects on multiple genes and cell signaling pathways. Results from clinical trials using these compounds have not shown them to be chemopreventive. This may be due to our:(1) inability to reproduce the exposure conditions, i.e., levels, complexity, other host and lifestyle factors; and(2) lack of understanding about the mechanisms of action and agent-mediated toxicity in several organs and physiological processes in the host. Current research efforts in addressing the issues of exposure conditions, bioavailability, toxicity and the mode of action of dietary phytochemicals may help address the reason for observed mismatch that may ultimately lead to identification of new chemopreventive agents for protection against broad spectrum of exposures. | Girish B Maru Rasika R Hudlikar Gaurav Kumar Khushboo Gandhi Manoj B Mahimkar | 2016 | World Journal of Biological Chemistry2016，7，1： | 2 |
| 3 | Respiratory supercomplexes:structure,function and assembly显示文摘The mitochondrial respiratory chain consists of 5 enzyme complexes that are responsible for ATP generation.The paradigm of the electron transport chain as discrete enzymes diffused in the inner mitochondrial membrane has been replaced by the solid state supercomplex model wherein the respiratory complexes associate with each other to form supramolecular complexes.Defects in these supercomplexes,which have been shown to be functionally active and required for forming stable respiratory complexes,have been associated with many genetic and neurodegenerative disorders demonstrating their biomedical signifi cance.In this review,we will summarize the functional and structural signifi cance of supercomplexes and provide a comprehensive review of their assembly and the assembly factors currently known to play a role in this process. | Rasika Vartak Christina Ann-Marie Porras Yidong Bai | 2013 | Protein & Cell2013，4，8： | 2 |
| 4 | Leukemia inhibitory factor is a key signal for injury-induced neurogenesis in the adult mouse olfactory epithelium显示文摘 | Rasika S Han J Mauduit C Raccurt M Morel G | 2003 | J Nevi2003，23，5： | 1 |
| 5 | Leukemia inhibitory factor is a key signal for injury-induced neurogenesis in the adult mouse olfactory epithelium显示文摘 | Bauer S Rasika S Han J | 2003 | J Neurosci2003，23，5： | 1 |
| 6 | Brightly Phosphorescent Trinuclear Copper (Ⅰ) Complexes of Pyrazolates:Substituent Effects on the Supramolecular Structure and Photophysics显示文摘 | Rasika D H V Diyabalanage H V K Eldabaja M G | 2005 | J Am Chem Soc2005，127，20： | 1 |
| 7 | Heritability of Platelet Responsiveness to Aspirin in Activation Pathways Directly and Indirectly Related to Cyclooxygenase-1显示文摘 | Nauder Faraday Lisa R. Yanek Rasika Mathias J Enrique Herrera-Galeano Dhananjay Vaidya Taryn F. Moy M Daniele Fallin Alexander F. Wilson Paul F. Bray Lewis C. Becker Diane M. Becker | 2007 | Circulation2007，，19： | 1 |
| 8 | Cu: AI Nano Catalyst for Selective Hydrogenolysis of Glycerol to 1,2-Propanediol显示文摘 | Rasika B Mane Amol M Hengne AjayA Ghalwadkar | 2010 | Catal Lett2010，135，： | 1 |
| 9 | Graft copolymerization onto cellulose-based filter paper and its further development as silver nanoparticles load- ed antibacterial food-packaging material显示文摘 | RASIKA T BAJPAI S K | 2009 | Colloids and Surfaces B: Biointerfaces2009，，69： | 1 |
| 10 | Preparation, characterization and antibacterial applications of ZnO-nanoparticles coated polyethylene films for food packaging显示文摘 | Rasika Tankhiwale S.K. Bajpai | 2011 | Colloids and Surfaces B: Biointerfaces2011，，： | 1 |
| 11 | Graft copolymerization onto cellulose-based filter paper and its further development as silver nanoparticles loaded antibacterial food-packaging material显示文摘 | Rasika Tankhiwale S.K. Bajpai | 2008 | Colloids and Surfaces B: Biointerfaces2008，，2： | 1 |
| 12 | The greener synthesis of nanoparticles显示文摘 | Oxana V. Kharissova H.V. Rasika Dias Boris I. Kharisov Betsabee Olvera Pérez Victor M. Jiménez Pérez | 2013 | Trends in Biotechnology2013，，4： | 1 |
| 13 | Molecular pathways in cerebral ischemia: cues to novel therapeutic strategies显示文摘 | Rasika S Benchoua A | 2003 | Mol Neurobiol2003，27，1： | 1 |
| 14 | The greener synthesis of nanoparticles显示文摘 | KHARISSOVA O V RASIKA DIAS H V KHARISOV B I | 2013 | Trends in Biotechnology2013，31，4： | 1 |
| 15 | Electronic stabilization of nucleophilic carbenes 显示文摘 | Arduengo A J Rasika Dias H V Harlow R L | 1992 | J Am Chem Soc1992，114，： | 1 |
| 16 | Leukemia inhibitory factor is a key signal for injury-induced neurogenesis in the adult mouse olfactory epithelium显示文摘 | Bauer S Rasika S Han J | 2003 | J Neurosci2003，23，5： | 1 |
| 17 | A Study of the solubilization of polar oily materials by alkyl polyglucoside and sodium dodecyl sulfate in mixed surfactant system显示文摘 | Rasika MS Manohar RS | 2006 | Journal of Dispersion Science and Technology2006，27，： | 1 |
| 18 | Antioxidant potential from stem bark ofJuglans regia L显示文摘 | Asha A Kale Rasika C | | 0，，01： | 1 |
| 19 | Industrial Practices of Research Conversion and Technology Transfer显示文摘 | Albert H Rubenstein Eliezer Geisler Rasika Abeysinghe | 1997 | The Journal of Technology Transfer1997，22，： | 1 |
| 20 | Investigation of dynamic release of vitamin B 2 from calcium alginate/chitosan multilayered beads: Part II显示文摘 | S.K. Bajpai Rasika Tankhiwale | 2006 | Reactive and Functional Polymers2006，，12： | 1 |
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