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| 1 | Interferon-a plus lamivudine vslamivudine reduces breakthroughs, but does not affect sustained response in HBeAg negative chronic hepatitis B显示文摘AIM: To investigate the efficacy of combination treatment of IFN-α and lamivudine compared to lamivudine monotherapy, after 24 mo of administration in HBeAg-negative hepatitis B patients.METHODS: Fifty consecutive patients were randomly assigned to receive IFN-α-2b (5 MU thrice per week, n = 24) plus lamivudine (100 mg daily) or lamivudine only (n = 26) for 24 mo. Patients were followed up for further 6 mo. The primary outcome was the proportion with sustained virological response (undetectable serum HBV DNA concentrations) and or sustained biochemical response (transaminase levels within normal range) at 30 mo (6 mo after the end of therapy). Secondary end-points were timed from initial virological (biochemical) response to VBR (BBR, respectively) and the emergence of YMDD mutants across the two arms.RESULTS: Five of twenty-four (21%) patients in the combination arm vs 3/26 (12%) in the lamivudine arm had sustained response (i.e., normal serum transaminase levels and undetectable HBV DNA by PCR assay) 6 mo after treatment discontinuation. A reduction in the emergence of YMDD mutants and in the development of virological breakthroughs was observed in patients receiving combination treatment (10% vs46%, P= 0.01 and 14% vs46%, P= 0.03,respectively).Time from initial virologic response to virologic breakthrough (VBR) was greater among initial responders receiving combination treatment compared to those receiving lamivudine (22.9 mo vs 15.9 mo, respectively; P = 0.005).CONCLUSION: Our results demonstrate that IFN-α plus lamivudine combination therapy does not increase the sustained response, compared to lamivudine. However,combination therapy reduces the likelihood of VBR due to YMDD mutants and prolongs the time period until the breakthrough development. | Michalis Economou Spilios Manolakopoulos Thomas A Trikalinos Spyros Filis Sotiris Bethanis Dimitrios Tzourmakliotis Alec Avgerinos Sotiris Raptis Epameinondas V Tsianos | 2005 | World Journal of Gastroenterology2005，11，37： | 6 |
| 2 | The Effect of Scaling on Landeover Classification from Satellite Data显示文摘 | Raptis V S Vaughan R A Wright G G | 2003 | Computers and Geosciences2003，29，6： | 1 |
| 3 | Thermally induced irreversible conformational changes in collagen probed by optical second harmonic generation and laser-induced fluorescence显示文摘 | Theodossiou T Rapti GS Hovhannisyan V | | 0，，01： | 1 |
| 4 | Elevated pulmonary arterial systolic pressure in patients with sarcoidosis: prevalence and risk factors显示文摘 | Rapti A Kouranos V Gialafos E | 2013 | Lung2013，191，1： | 1 |
| 5 | Thepotential of kernel classification techniques for land use mapping in urban areas using 5M-spatial resolution IRS-IC imagery显示文摘 | Kontoes C C Raptis V | 2000 | International Journal of Remote Sensing2000，21，16： | 1 |
| 6 | Evaluation of solid sorbents for the determination of fenhexamid, metalaxyl-M, pyrimethanil, malathion and myclobutanil residues in air samples:Application to monitoring mala- thion and fenhexamid dissipation in greenhouse air using C-18 or Supelpak-2 for sampling显示文摘 | Tsiropoulos N G Bakeas E B Raptis V | 2006 | Analytica Chimica Acta2006，，： | 1 |
| 7 | Thermally induced irreversible eonformational changes in collagen probed by optical second harmonic generation and laser-induced fluorescence 显示文摘 | Theodossious T Rapti G S Hovhannisyan V | 2002 | Laser in Med Science2002，17，1： | 1 |
| 8 | The effect of scaling on land cover classification from satellite data显示文摘 | VAUGHAN R A WRIGHT G G | 2003 | Computers and Geosciences2003，29，6： | 1 |
| 9 | Characterization of the AB Loop Region of TIMP-2 : involvement in Pro-MMP-2 Activation 显示文摘 | Rapti M Knatlper V Murphy G | 2006 | J Biol Chem2006，281，23： | 1 |
| 10 | Platinum-based and non-platinum-based chemotherapy in advanced non-small-cell lung cancer: a randomised multicentre trial显示文摘 | V Georgoulias E Papadakis A Alexopoulos X Tsiafaki A Rapti M Veslemes Ph Palamidas I Vlachonikolis | 2001 | The Lancet . 2001 (9267)2001，，9267： | 1 |
| 11 | A fault-tolerant message passing algorithm and its hardware implementation显示文摘 | Sirakoulis G Raptis V Karafyllidis I | 2005 | Advances in Engineering Software2005，36，： | 1 |
| 12 | Characterization of the A loop Re- gion of TIMP-2 :involvement in Pro-MMP-2 aetivation显示文摘 | Rapti M Knaiiper V Murphy G | 2006 | J Biol Chem2006，281，23： | 1 |
| 13 | The potential of kernel classification techniques for land use mapping in urban areas using 5M-spatial resolution IRS-1C imagery显示文摘 | Kontoes C C Raptis V | 2000 | Int J Remote Sensing2000，21，16： | 1 |
| 14 | Sustained responses and loss of HBsAg in HBeAg-negative patients with chronic hepatitis B who stop long- term treatment with adefovir显示文摘 | Hadziyannis SJ Sevastianos V Rapti I | 2012 | Gastroenterolog)52012，143，3： | 1 |
| 15 | The Potential of Kernel Classification Techniques for Land Use Mapping in Urban Areas Using 5m Spatial Resolution IRS-1C Imagery显示文摘 | Kontoes C C Raptis V Laumer M | 2000 | International Journal of Remote Sensing of Environment2000，21，16： | 1 |
| 16 | Magnetohydrodynamic flow past a plate by the presence of radiation显示文摘 | Raptis A Massalas C V | 1998 | Heat and Mass Transfer1998，34，23： | 1 |
| 17 | Role of asymmetrical dimethylargin- ine in the progression of renal disease显示文摘 | Raptis V Kapoulas S Grekas D | 2013 | Nephrology(Carlton)2013，18，1： | 1 |
| 18 | The effect of scaling on land cover classification from satellite data 显示文摘 | RAPTIS V S VAUGHAN R A WRIGHT G G | 2003 | Computers and Geosciences2003，29，6： | 1 |
| 19 | Characterization of the ABLoop region of TIMP - 2; involvement in Pro - MMP - 2 activation 显示文摘 | Rapti M Knauper V Murphy G | 2006 | J Biol Chem2006，281，23： | 1 |
| 20 | Characterization of the AB Loop Region of TIMP-2: involvement in Pro-MMP-2 Activation 显示文摘 | Rapti M Knaiiper V Murphy G | 2006 | J Biol Chem2006，281，23： | 1 |
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