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| 1 | Antioxidant and antimutagenic activities of bark extract of Terminalia arjuna显示文摘Objective:The alcoholic extract of stem bark of Terminalia arjuna(ALTA) was screened for antioxidant and antimutagenic(anticlastogenic) activity.Methods:Antioxidant property was determined by l,l,Diphynyl,2-Picryl hydrazyl(DPPH) assay,super oxide radical scavenging activity,lipid peroxidation assay and total polyphenolic content was determined by Folin-Ciocalteau’s reagent.Antimutagenic activity was evaluated using micronucleus test in mice. Results:The ALTA has shown potent antioxidant activity with EC50 of 2.491±0.160,50.110±0.150 & 71.000±0.250 in DPPH assay,superoxide radical scavenging activity and lipid peroxidation assay, which is comparable with ascorbic acid with EC50 of 2.471±0.140,40.500±0.390 and 63.000±0.360 respectively.In micronucleus test,ALTA(100 & 200 mg/kg,p.o.) showed significant reduction in percentage of micronucleus in both polychromatic erythrocytes(PCE) and normochromatie erythrocytes(NCE) and also shown significant reduction in P/N ratio.Conclusions:These results suggested that ALTA possess significant antioxidant and antimutagenic activity. | Gollapalle Lakshminarayana shastry Viswanatha Santosh Kumar Vaidya Ramesh C Nandakumar Krishnadas Srinath Rangappa | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，12： | 9 |
| 2 | 印度草药方NR/CAL/06的甲醇提取物对卵巢切除大鼠的抗骨质疏松作用(英文)显示文摘目的:证实印度草药方NR/CAL/06的甲醇提取物对卵巢切除大鼠的抗骨质疏松作用。方法:雌性Sprague-Drawley大鼠在无菌状态下行双侧卵巢切除术后被分为5组(n=10)。检测NR/CAL/06的甲醇提取物(200和400mg/kg口服)的抗骨质疏松作用并以雷洛昔芬(5.4mg/kg口服)作为标准对照药,治疗时间为90d。实验前后测量各组大鼠的体质量、卵巢质量、骨质量、骨矿物质含量、骨强度,血清及尿液中的钙、磷含量及血清碱性磷酸酶含量。电镜下观察大鼠股骨外径、长度及厚度。结果:双侧卵巢切除术后,大鼠骨质量、骨矿物质含量及骨强度均有下降;电镜观察到卵巢切除大鼠股骨骨质疏松、多孔、破碎,且骨长度及厚度均有所下降。与假手术组相比,卵巢切除大鼠的血清钙、磷及碱性磷酸酶含量均有所升高,体质量及脂肪含量升高,子宫质量降低。NR/CAL/06的甲醇提取物(200和400mg/kg口服)治疗90d能够剂量依赖性地改变大鼠因卵巢切除所引起的上述各项指标变化,并将骨质量、骨矿物质含量、骨强度,血清钙、磷及碱性磷酸酶含量,体质量及脂肪含量恢复至正常水平。此外,经NR/CAL/06的甲醇提取物(200和400mg/kg口服)治疗的大鼠与卵巢切除模型组大鼠相比,电镜下股骨骨质孔形成减少,骨密度增加。结论:本实验的结果证实了NR/CAL/06的甲醇提取物具有很好的抗骨质疏松作用,可用于骨质疏松症的治疗。 | Praveen Srikanta Shivaprasad H.Nagarajappa Gollapalle L.Viswanatha. Mukund Handral Rajesh Subbanna Rangappa Srinath Ganesh Hiremath | 2011 | 中西医结合学报2011，9，10： | 2 |
| 3 | Cardiomyocytemediated contact programs human mesenchymal stem cells to express cardiogenic phenotype显示文摘 | Rangappa S Entwistle J Wechsler A | 2003 | Thorac Cardiovasc Surg2003，126，1： | 1 |
| 4 | programs human mesenehymal stem cells to express eardiogenie phenotype 显示文摘 | Rangappa S Entwisth Weehsler AS | 2003 | J Thorns Cardiovase Surg2003，126，1： | 1 |
| 5 | Transformation of adult mesenchymal stem ceils isolated from the fatty tissue in- to cardiomyocytes显示文摘 | RANGAPPA S FEN C LEE E H | 2003 | Ann Thorae Surg2003，75，3： | 1 |
| 6 | Transforroation of adult mesenchyreal stem ceils isolated from the fatty tissue into cardiomyocytes 显示文摘 | Rangappa S Fen C Lee EH | 2003 | Amm Thorac Surg2003，75，3： | 1 |
| 7 | Transformation of adult mesenchymal stem cells isolated from the fatty tissue into eardiomyocytes显示文摘 | Rangappa S Fen C Lee E H | 2003 | Ann Thorac Surg2003，75，3： | 1 |
| 8 | Cardiomyocyte-mediated contact programs human mesenchymal stem cells to express cardiogenic phenotype显示文摘 | Rangappa S Entwistle JW Wechsler AS | 2003 | J Thorac Cardiovasc Surg2003，126，1： | 1 |
| 9 | Spectrophotometric method for the determination ofparacetam-olandphenacetin显示文摘 | Rangappa K S Pharm J | 1998 | BiomedAnal1998，17，3： | 1 |
| 10 | Cardiomyocyte-mediated contact programs human mesenchymal stem cells to express cardiogenic phenotype 显示文摘 | Rangappa S Entwistle J W Wechsler A S | 2003 | J Thorac Cardiovasc Surg2003，126，1： | 1 |
| 11 | Spectrophotometric Methods for the Determination of Certain Catecholamine Derivatives in Pharmaceutical Ppreparations 显示文摘 | NAJARAJA P MURTHY K C S RANGAPPA K S | 1998 | Talanta1998，46，5： | 1 |
| 12 | Transformation of the adult human mesenchymal stem cells into cardiomyoeyte-like cells in vivo 显示文摘 | Rangappa S Reddy VG Bongso A | 2002 | Cardiovasc Eng2002，2，1： | 1 |
| 13 | Transformation of the adult human mesenchymal stem cells into cardiomyocyte - like cells in vivo显示文摘 | Rangappa S Reddy V G Bongso A | 2002 | Cardivasular Engineering2002，2，1： | 1 |
| 14 | Transformation of adult mesenchymal stem cells isolated from the fatty tissue into cardio- myocytes 显示文摘 | Rangappa S Fen C Lee EH | 2003 | Ann Thorac Surg2003，75，3： | 1 |
| 15 | Transformation of adult mesenchymal stem cells isolated from the fatty tissue into cardiomyocytes显示文摘 | Rangappa S Chen Fen Lee EH | 2003 | Ann Thorac Surg2003，75，： | 1 |
| 16 | Approximate hydrodynamic analysis of multicolumn ocean structures显示文摘 | Williams A N Rangappa T | 1994 | Ocean Engineering1994，21，6： | 1 |
| 17 | Cardiomyoctyemediated contact programs human mcsenehymal stem cells to express cardiogenic phenotype显示文摘 | Rangappa S Entwistle J W Weehsler A S | 2003 | J Thorac Cardiovasc Surg2003，126，： | 1 |
| 18 | Transformation of the adult human mesenchymal stem cells into cardiomyocyte-like cells in vivo显示文摘 | Rangappa S Reddy V G Bongso A | 2002 | Cardivasular Engineering2002，2，1： | 1 |
| 19 | Transformation of adult mesenchymal s tem cel l s is olated from the fatty t is sue i nto cardiomyocytes显示文摘 | Rangappa S Fen C Lee EH | 2003 | Ann Thorac Surg2003，75，3： | 1 |
| 20 | Transformation of the adult human mesenchymal stem cells into cardiomyocyte-like cells in vivo显示文摘 | Rangappa S Reddy V G Bongso A | 2002 | Cardiovasc Eng2002，，： | 1 |
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