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| 1 | Diagnosis of Crohn's disease in India where tuberculosis is widely prevalent显示文摘AIM:To define the parameters that positively predict diagnosis of Crohn's disease (CD) and differentiate it from gastrointestinal tuberculosis (GITB). METHODS:This prospective study over 3 years was carried out in the consecutive Indian patients with definite diagnosis of CD and equal numbers of patients with definite diagnosis of GITB. Demographic, clinical, laboratory, morphological and histological features were noted in all the patients. Serological tests such as p-ANCA, c-ANCA, IgA ASCA and IgG ASCA, were performed. Endoscopic biopsy and/or surgical tissue specimens were subjected to smear and culture for acid-fast bacilli (AFB) and tissue polymerase chain reaction for tuberculosis (TB PCR). Diagnosis of CD and GITB was based on the standard criteria. Data were analyzed using univariate Chi-square test and multiple logistic regression (MLR). RESULTS:The study is comprised of 26 patients with CD (age 36.6 ± 8.6 year, male:female, 16:10) and 26 patients with GITB (age 37.2 ± 9.6 year, male:female, 15:11). The following clinical variables between the two groups (CD vs TB) were significant in univariate analysis:duration of symptoms (58.1 ± 9.8 vs 7.2 ± 3.4 mo), diarrhoea (69.2% vs 34.6%), bleeding per rectum (30.7% vs 3.8%), fever (23.1% vs 69.2%), ascites (7.7% vs 34.6%) and extra-intestinal manifestations of inflammatory bowel disease (61.5% vs 23.1%). Of these, all except ascites and extra-colonic manifestations were found statistically significant by MLR. Accuracy of predicting CD was 84.62% based on the fever, bleeding P/R, diarrhoea and duration of symptoms while it was 63.4% when histology was reported as inflammatory bowel disease and 42.3% when there was recurrence of disease after surgery. Accuracy of predicting GITB was 73.1% when there was co-existing pulmonary lesions and/or abdominal lymphadenopathy;75% when tuberculosis was reported in histology;63.4% when granuloma was found in histology;82.6% when TB PCR was positive;and 61.5% when smear and/ or culture was positive for AFB. Serological test was not useful in differentiation of CD from GITB. Positivity rates for CD and GITB were:p-ANCA-3.8% and 3.8%, c-ANCA-3.8% and 0%, IgA ASCA-38.4% and 23.1%, and IgG ASCA-38.4% and 42.3%, respectively. CONCLUSION:Simple clinical parameters like fever, bleeding P/R, diarrhoea and duration of symptoms have the highest accuracy in differentiating CD from GITB. | Deepak N Amarapurkar Nikhil D Patel Priyamvada S Rane | 2008 | World Journal of Gastroenterology2008，14，5： | 24 |
| 2 | Early onset discordant growth in a successful monochorionic twin pregnancy显示文摘 | Smithson N Isherwood P Rane A | 2002 | BJOG2002，109，： | 1 |
| 3 | Temperature fields in a chip during high- speed orthogonal cutting-an experimental investigation 显示文摘 | G Sutter N Rane | 2007 | International Journal of Maehine Tools and Manufacture2007，47，10： | 1 |
| 4 | Depression in patients with cardiac disease: a practical review 显示文摘 | Lespe rane F Frasure-Smith N | 2000 | J of Psychosomatic Research2000，48，： | 1 |
| 5 | RhoB is dispensable for mouse development, but it modifies susceptibility to tumor formation as well as cell adhesion and growth factor signaling in transformed cells 显示文摘 | LIU A X RANE N LIU J P | 2001 | Mol Cell Biol2001，21，： | 1 |
| 6 | Control of root system architecture by DEEPER ROOTING 1 increases rice yield under drought conditions显示文摘 | Uga Y Sugimoto K Ogawa S Rane J Ishitani M Hara N Kitomi Y Inukai Y Ono K Kanno N Inoue H Takehisa H Motoyama R Nagamura Y Wu J Z Matsumoto T Takai T Okuno K Yano M | 2013 | Nature Genetics2013，45，9： | 1 |
| 7 | pH sensitive polyelectrolyte complex of O-carboxymethyl chitosan and poly(acrylic acid)cross-linked with calcium for sustained delivery of acid susceptible drugs显示文摘 | Gujarathi N A Rane B R Patel J K | 2012 | Int J Pharm2012，436，12： | 1 |
| 8 | Syndrome nephrotique: penser a rechercher une hypothyroidie associee nephrotic syndrome: don't forget to search for hypolhyroidism显示文摘 | Trouillier S Delevaux I Ranee N | 2008 | La Revue de Medecine Interne2008，29，： | 1 |
| 9 | Aortic root reconstruction with a hioprosthetic valved conduit: a consecutive series of 275 procedures 显示文摘 | Etz CD Homann TM Rane N | 2007 | J Thorac Cardiovasc Surg2007，133，6： | 1 |
| 10 | Cracking of n-heptane over Bronsted Acid Sites and Lewis Acid Ga Sites in ZSM-5 Zeolite显示文摘 | Rane N Kersbulck M Van S R A et at | 2008 | Microporous and Mesoporous Materials2008，110，： | 1 |
| 11 | Reactive oxygen species regulation by AIF - and complex I - depleted brain mitochondria 显示文摘 | Chinta SJ Rane A Yadava N | 2009 | Free Radic Biol Med2009，46，7： | 1 |
| 12 | Farnesyltransferase inhibitors: mechanism and applications 显示文摘 | Prendergast G C Rane N | 2001 | Expert Opin Investig Drugs2001，10，12： | 1 |
| 13 | Deforming grid generation and CFD analysis of variable geometry screw compressors显示文摘 | RANE S KOVACEVIC A STOSIC N | 2014 | Computers&Fluids2014，99，： | 1 |
| 14 | Isomap tracking with particle filtering显示文摘 | Rane N Birchfield S | 2007 | IEEE International Conference on Image Processing2007，，2： | 1 |
| 15 | Farnesyltransferase inhibitors: mechanism and applications 显示文摘 | Prendergast G C Rane N | 2001 | Expert Opin Investig Drugs2001，10，12： | 1 |
| 16 | Surface modification of Angora rabbit fibers using dielectric barrier discharge显示文摘 | Danish N Garg M K Rane R S | 2007 | Applied Surface Science2007，253，16： | 1 |
| 17 | Splenic tumours autopsy study of ten years显示文摘 | Rane R Bagwan N Pingle P | 2005 | Indian j Pathol Microbiol2005，48，2： | 1 |
| 18 | Biochemical Change in Totopuri Mango During Ripening and Storage显示文摘 | KAPSE M B RANE D A KULKARNI D N INGLE V M | 1977 | South Indian Hortculture1977，25，3： | 1 |
| 19 | Alternative splicing of interleukin-7 (IL-7) and interleukin-7 receptor alpha (IL-7Ralpha) in peripheral blood from patients with multiple sclerosis (MS)显示文摘 | Rane L Vudattu N Bourcier K | 2010 | J Neuroimmunol2010，222，12： | 1 |
| 20 | Cytosolic aggregates perturb the degradation of nontranslocated secretory and membrane proteins显示文摘 | Chakrabarti O Rane N S Hegde R S | 2011 | Mol Biol Cell2011，22，10： | 1 |
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