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| 1 | Insulin-like growth factor binding protein-5 influences pancreatic cancer cell growth显示文摘AIM: To investigate the functional significance of insulin-like growth factor binding protein-5 (IGFBP-5) overexpression in pancreatic cancer (PaC).METHODS: The effects of IGFBP-5 on cell growth were assessed by stable transfection of BxPC-3 and PANC-1 cell lines and measuring cell number and DNA synthesis. Alterations in the cell cycle were assessed by flow cytometry and immunoblot analyses. Changes in cell survival and signal transduction were evaluated after mitogen activated protein kinase and phosphatidylinositol 3-kinase (PI3K) inhibitor treatment.RESULTS: After serum deprivation, IGFBP-5 expression increased both cell number and DNA synthesis in BxPC-3 cells, but reduced cell number in PANC-1 cells. Consistent with this observation, cell cycle analysis of IGFBP-5-expressing cells revealed accelerated cell cycle progression in BxPC-3 and G2/M arrest of PANC-1 cells. Signal transduction analysis revealed that Akt activation was increased in BxPC-3, but reduced in PANC-1 cells that express IGFBP-5. Inhibition of PI3K with LY294002 suppressed extracellular signal-regulated kinase-1 and -2 (ERK1/2) activation in BxPC-3, but enhanced ERK1/2 activation in PANC-1 cells that express IGFBP-5. When MEK1/2 was blocked, Akt activation remained elevated in IGFBP-5 expressing PaC cells; however, inhibition of PI3K or MEK1/2 abrogated IGFBP-5-mediated cell survival.CONCLUSION: These results indicate that IGFBP-5 expression affects the cell cycle and survival signal pathways and thus it may be an important mediator of PaC cell growth. | Sarah K Johnson Randy S Haun | 2009 | World Journal of Gastroenterology2009，15，27： | 5 |
| 2 | 伦理学与SARS:多伦多的教训显示文摘SARS的流行说明传染病在世界范围内流行是件多么容易的事,为了更好地应对下一次流行病,我们不仅要解决医学方面的问题,也同样需要解决伦理学方面的问题。 | Peter A Singer Solomon R Benatar Mark Bernstein Abdallah S Daar Bernard M Dickens Susan K MacRae Ross E G Upshur Linda Wright Randi Zlotnik Shaul 肖月 | 2004 | 英国医学杂志中文版2004，7，4： | 3 |
| 3 | Size, oxygen consumption and growth in the mussule (Mythlus edulis )显示文摘 | Hanburger K Mθhlenberg F Randiθv A | 1983 | Marine Biology1983，75，： | 2 |
| 4 | The criminal justiceresponse to elder abuse in nursing homes : A routine activitiesapproach显示文摘 | BRIAN K PAYNE RANDY R GAINEY | 2006 | Western Criminology Review2006，，7： | 1 |
| 5 | Carbon and nitrogen dynamics in a forest soil amended with purified tannins from different plant species显示文摘 | Tamara E C K Robert J Z Randy A D | 2004 | Soil Biol Biochem2004，36，2： | 1 |
| 6 | Effect of chloroplastic overproduc-tion of ascorbate peroxidase on photo-synthesis and photoprotection in cotton leaves subjected to low temperature photoinhibition显示文摘 | DMYTRO K BARRY AL RANDY DA | 2003 | Plant Science2003，165，： | 1 |
| 7 | Adaptation and mobility in wireless information systems 显示文摘 | RANDY H K | 1995 | Adaptation and Mobility in Wireless Information Systems1995，1，： | 1 |
| 8 | A view of cloud computing显示文摘 | MICHAEL A ARMANDO F REAN Q ANTHONY D J RANDY K ANDY K GUNHO L DAVID P ARIEL R ION S MATEI Z | 2010 | Communications of the ACM2010，53，4： | 1 |
| 9 | Poly((2,5-dialkoxy-p-phenylene) ethnylene-phenyleneethynylene)s and their model compounds 显示文摘 | Li Hong PowelI D R Randy K | 1998 | Macromolecules1998，31，1： | 1 |
| 10 | Effects of image compression on iris recognition system performance显示文摘 | Robert W I Randy P B Lauren R K | 2008 | Journal of Electronic Imaging2008，17，01： | 1 |
| 11 | Pregnancy - specific asso- ciation of vitamin D deficiency and bacterial vaginosis 显示文摘 | Hensel K J Randis TM Gelber SE | 2011 | Am J Obstet Gynecol2011，，41： | 1 |
| 12 | Fermentative produc- tion of lactic acid from biomass: an overview on process developments and future perspectives显示文摘 | ROJAN P J NAMPOOTHIRI K M RANDY A | 2007 | Appl Microbiol Biotechnol2007，74，3： | 1 |
| 13 | Tannins in nutrient dynamics of forest ecosystems-a review显示文摘 | Tamara E C K Randy A D Robert J Z | 2003 | Plant Soil2003，256，1： | 1 |
| 14 | Psychometrics in the supersaturated frost zone显示文摘 | Mago Pedro J Al-Mutawa Nawaf K Theen Randy S | 2001 | ASHRAE Transactions2001，107，2： | 1 |
| 15 | Gauging e-government: A report on implementing services among American cities 显示文摘 | Charles K Randy D David V E | 2001 | Government Information Quarterly2001，，18： | 1 |
| 16 | Lunar surfacegeochemistry: Global concentrations of Th, K, andFeO as derived from lunar prospector and Clementinedata显示文摘 | Jeffrey J G Bradley L J Randy L K | 2004 | Geochimic a Cosmochimica Acta2004，68，18： | 1 |
| 17 | Shivering, muscle tone, and uncoupling proteins in a developing marsupial, the Tasmanian bettong (Bettongia gaimardi) 显示文摘 | Alexander P K Randy W R Adrian K W | 2007 | J Thermal Biol2007，32，： | 1 |
| 18 | Poly ((2, 5-dialkoxy-p-phenylene)ethynylene-p-phenyl-eneethynylene)s and their model compounds 显示文摘 | Li Hong Powell D R Randy K | 1998 | Macromolecules1998，31，1： | 1 |
| 19 | Field testing plant growth regulators and wetting agents for seedhead suppression of annual bluegrass显示文摘 | Randy K Miller L | 2002 | USAG turfgrass and environmental research online2002，2，7： | 1 |
| 20 | Ethical work climate in the development of person-organization fit显示文摘 | Randi S Thomas K | 2010 | Journal of Business Ethics2010，29，11： | 1 |
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