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| 1 | The amazing potential of fungi:50 ways we can exploit fungi industrially显示文摘Fungi are an understudied,biotechnologically valuable group of organisms.Due to the immense range of habitats that fungi inhabit,and the consequent need to compete against a diverse array of other fungi,bacteria,and animals,fungi have developed numerous survival mechanisms.The unique attributes of fungi thus herald great promise for their application in biotechnology and industry.Moreover,fungi can be grown with relative ease,making production at scale viable.The search for fungal biodiversity,and the construction of a living fungi collection,both have incredible economic potential in locating organisms with novel industrial uses that will lead to novel products.This manuscript reviews fifty ways in which fungi can potentially be utilized as biotechnology.We provide notes and examples for each potential exploitation and give examples from our own work and the work of other notable researchers.We also provide a flow chart that can be used to convince funding bodies of the importance of fungi for biotechnological research and as potential products.Fungi have provided the world with penicillin,lovastatin,and other globally significant medicines,and they remain an untapped resource with enormous industrial potential. | Kevin D.Hyde Jianchu Xu Sylvie Rapior Rajesh Jeewon Saisamorn Lumyong Allen Grace T.Niego Pranami D.Abeywickrama Janith V.S.Aluthmuhandiram Rashika S.Brahamanage Siraprapa Brooks Amornrat Chaiyasen K.W.Thilini Chethana Putarak Chomnunti Clara Chepkirui Boontiya Chuankid Nimali I.de Silva Mingkwan Doilom Craig Faulds Eleni Gentekaki Venkat Gopalan Pattana Kakumyan Dulanjalee Harishchandra Hridya Hemachandran Sinang Hongsanan Anuruddha Karunarathna Samantha C.Karunarathna Sehroon Khan Jaturong Kumla Ruvishika S.Jayawardena Jian-Kui Liu Ningguo Liu Thatsanee Luangharn Allan Patrick G.Macabeo Diana S.Marasinghe Dan Meeks Peter E.Mortimer Peter Mueller Sadia Nadir Karaba N.Nataraja Sureeporn Nontachaiyapoom Meghan O’Brien Watsana Penkhrue Chayanard Phukhamsakda Uma Shaanker Ramanan Achala R.Rathnayaka Resurreccion B.Sadaba Birthe Sandargo Binu C.Samarakoon Danushka S.Tennakoon Ramamoorthy Siva Wasan Sriprom T.S.Suryanarayanan Kanaporn Sujarit Nakarin Suwannarach Thitipone Suwunwong Benjarong Thongbai Naritsada Thongklang Deping Wei S.Nuwanthika Wijesinghe Jake Winiski Jiye Yan Erandi Yasanthika Marc Stadler | 2019 | Fungal Diversity2019，，4： | 3 |
| 2 | Malaria: current status of control, diagnosis, treatment, and a proposed agenda for research and development显示文摘 | Philippe J Guerin Piero Olliaro Francois Nosten Pierre Druilhe Ramanan Laxminarayan Fred Binka Wen L Kilama Nathan Ford Nicholas J White | 2002 | The Lancet Infectious Diseases2002，，9： | 2 |
| 3 | 美国和欧洲生物类似药的发展(英文)显示文摘生物类似药(biosimilars)是与已批准上市的生物制品高度相似的药物,与小分子仿制药物(generics)不同,生物类似药并不是他们参比制品的精确复制品。尽管高度相似,生物类似药在某些方面仍然可能与参比制品不同,生物类似药间也会互不相同。生物制品不仅由于其复杂的性质和生产过程,还由于存在独特的免疫原性和活性的安全隐患,给研发和监管带来了相当大的挑战。欧洲药品管理局和美国食品药品管理局的指导原则建议采用'证据链完备性'(totality-of-evidence)的方法全面覆盖生物类似药物开发的各个步骤,包括分析表征化、结构相似性和功能等效性等的证据。这种'证据链完备性'是生物类似药整个研发过程中其余工作的基石,包括必须的动物试验研究、人体药代动力学/药效学研究,以及至少1个临床研究,以证实生物类似药功效等效,并且免疫原性或安全性风险没有增加。临床研究应选择敏感人群来进行试验,以便发现任何有临床意义的差异。工艺稳定质量恒定的生物类似药的研发需要丰富的经验和专业技能,只有这样才能够确保患者得到良好治疗。 | Richard Markus Victor Fung Sundar Ramanan | 2015 | 药物分析杂志2015，35，5： | 2 |
| 4 | Utilization of plant-based natural coagulants as future alternatives towards sustainable water clarification显示文摘Rapid industrial developments coupled with surging population growth have complicated issues dealing with water scarcity as the quest for clean and sanitized water intensifies globally. Existing fresh water supplies could be contaminated with organic, inorganic and biological matters that have potential harm to the society. Turbidity in general is a measure of water cloudiness induced by such colloidal and suspended matters and is also one of the major criteria in raw water monitoring to meet the stipulated water quality guidelines.Turbidity reduction is often accomplished using chemical coagulants such as alum. The use of alum is widely associated with potential development of health issues and generation of voluminous sludge. Natural coagulants that are available in abundance can certainly be considered in addressing the drawbacks associated with the use of chemical coagulants.Twenty one types of plant-based natural coagulants categorized as fruit waste and others are identified and presented collectively with their research summary in this review. The barriers and prospects of commercialization of natural coagulants in near future are also discussed. | Sook Yan Choy Krishna Murthy Nagendra Prasad Ta Yeong Wu Mavinakere Eshwaraiah Raghunandan Ramakrishnan Nagasundara Ramanan | 2014 | Journal of Environmental Sciences2014，26，11： | 2 |
| 5 | Macrophage activation syndrome: what's in a name! 显示文摘 | Ramanan AV Schneider R | 2003 | J Rheumatol2003，30，12： | 1 |
| 6 | Systemic juvenile idiopathic arthritis, Kikuchi's disease and haemophagocytic lymphohistiocytosis-is there a link? Case report and literature review 显示文摘 | Ramanan AV Wynn RF Kelsey A | 2003 | Rheumatology [Oxford]2003，42，4： | 1 |
| 7 | Providing quality of service over a shared wireless link显示文摘 | ANDREWS M KUMARAN K RAMANAN K | 2001 | IEEE Communications Magazine2001，，： | 1 |
| 8 | A high-affinity iron permease essentialfor Candida albicans virulence显示文摘 | Ramanan N | 2000 | Science2000，288，5468： | 1 |
| 9 | Structural basis for Marburg virus VP35-mediated immune evasion mechanisms显示文摘 | Ramanan P Edwards MR Shabman RS | 2012 | Proc Nail Acad Sci U S A2012，109，20： | 1 |
| 10 | Serum response factor mediates NGF-de- pendent target irmervation by embryonic DRG sensory neurons显示文摘 | Wickramasinghe SR Alvania RS Ramanan N | 2008 | Neuron2008，58，： | 1 |
| 11 | Thermal characterization of Al2O3 and ZnO reinforced silicone rubber as thermal pads for heat dissipation purposes 显示文摘 | Sim L C Ramanan S R Ismail H | 2005 | Thermochimia Acta2005，430，12： | 1 |
| 12 | Thermal characterization of Al2O3 and ZnO reinforced silicone rubber as thermal pads for heat dissipation purposes显示文摘 | SIM L C RAMANAN S R ISMAIL H | 2005 | Thermochimia Acta2005，430，12： | 1 |
| 13 | Favorable outcome in patients with renal involvement complicating macrophage activation syndrome in systemic onset juvenile rheumatoid arthritis显示文摘 | Ramanan AV Rosenblum ND Feldman BM | 2004 | J Rheumatol2004，31，10： | 1 |
| 14 | Thermal characterization of A1203 and ZnO reinforced silicone rubber as thermal pads for heat dissipation purposes 显示文摘 | Sim L C Ramanan S R Ismail H | 2005 | ThermochimicaActa2005，430，12： | 1 |
| 15 | The role of lac operon and lac repressor in the induction using lactose for the expression of periplasmic Escherichia coli显示文摘 | Tan JS Ramanan RN Ling TC | 2012 | Annals of human interferon-c2b by Microbiology2012，62，14： | 1 |
| 16 | On-line bin packing in linear time显示文摘 | Ramanan P Brown D Lee C Lee D | 1989 | Journal of Algorithms1989，10，3： | 1 |
| 17 | Clinical features and outcomes of juvenile dermatomyositis and other childhood onset myositis syndromes显示文摘 | Ramanan AV Feldman BM | 2002 | Rheum Dis Clin North Am2002，28，4： | 1 |
| 18 | Dip coated ITO thin-films through sol-gel process using metal salts 显示文摘 | Ramanan S R | 2001 | Thin Solid Films2001，389，： | 1 |
| 19 | Minimizing cycle time in large robotic cells显示文摘 | KUMAR S RAMANAN N SRISKANDARAJAH C | 2005 | liE Transactions2005，37，2： | 1 |
| 20 | Favorable outcomein patients with renal involvement complicating macrophage activation syndrome in systemic onset juvenile rheumatoid arthritis 显示文摘 | Ramanan A V Rosenblum N D Feldman B M | 2004 | J Rheumatol2004，31，10： | 1 |
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