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| 1 | Lipoprotein(a) in type 2 diabetic subjects and its relationship to diabetic microvascular complications显示文摘AIM: To estimate the level of serum lipoprotein (a) [Lp (a)] in type 2 diabetes mellitus patients and to determine the relationship between Lp(a) in type 2 diabetes mellitus patients and micro-vascular complications. METHODS: A cross sectional study was performed that enrolled 144 subjects with type 2 diabetes mellitus above the age of 25 years attending outpatient clinic of Government Medical College, Kozhikode. Lp(a) levels were measured quantitatively in venous samples using Turbidimetric Immunoassay in all subjects. Each patient was evaluated for micro vascular complications, namely diabetic retinopathy, nephropathy and neuropathy. The relationship between Lp(a) levels and the micro vascular complications was assessed by univariate analysis. RESULTS: Mean age of cases was 53.93 ± 10.74 years with a male to female ratio of 1.3:1. Mean duration of diabetes was 9.53 ± 7.3 years. Abnormal Lp(a) levels (≥ 30 mg/dL) were observed in 38 (26.4%) diabetic subjects. Seventy-eight (54.16%) cases had diabetic nephropathy and significantly higher Lp(a) levels were found among these cases [Median 28.2 mg/dL (Interquartile range; IQR 24.4-33.5) vs 19.3 mg/dL (IQR 14.7-23.5); P < 0.05]. Retinopathy was present among 66 (45.13%) cases and peripheral neuropathy was detected among 54 (37.5%) cases. However, Lp(a) levels were not significantly different among those with or without retinopathy and neuropathy. Positive correlation was found between higher Lp(a) levels and duration of diabetes (r = 0.165, P < 0.05) but not with HbA1c values (r = - 0.083). CONCLUSION: Abnormal Lp(a) levels were found among 26.4% of diabetic subjects. Patients with diabetic nephropathy had higher Lp(a) levels. No association was found between Lp(a) levels and diabetic retinopathy or neuropathy. Longer duration of diabetes correlated with higher Lp(a) levels. | Radhakrishnan Chandni Kollengode Parameswaran Ramamoorthy | 2012 | World Journal of Diabetes2012，3，5： | 13 |
| 2 | Natural orifice surgery: initial clinical experience显示文摘 | Santiago Horgan John P. Cullen Mark A. Talamini Yoav Mintz Alberto Ferreres Garth R. Jacobsen Bryan Sandler Julie Bosia Thomas Savides David W. Easter Michelle K. Savu Sonia L. Ramamoorthy Emily Whitcomb Sanjay Agarwal Emily Lukacz Guillermo Dominguez Ped | 2009 | Surgical Endoscopy2009，，7： | 5 |
| 3 | Pulmonary nocardiosis due to Nocardia otitidiscaviarum in an immunocompetent host-A rare case report显示文摘Nocardiosis is a localized or disseminated infection caused by soil-borne aerobic actinomycetes. Pulmonary nocardiosis is a rare infection mostly occurring in immunocompromised patients.We reported a case of 36 year old immunocompetent non-smoker female patient with no premorbid illness who presented with fever,cough with scanty sputum,hemoptysis,left sided chest pain and exertional dyspnea for two weeks.There was no past history of tuberculosis,diabetes mellitus or steroid therapy.Chest X-ray showed homogenous peripherally based opacity in the left upper zone.Bronchoscopy was done and brushing sent for culture,which showed colonies with features of Nocardia species after 48 hours.Further phenotypic characterization revealed it to be Nocardia otitidiscaviarum.Patient was treated with cotrimaxazole for six months after which complete recovery was evidenced symptomatically and radiologically.We report this case to emphasize the fact that among the Nocardia species,Nocardia otitidiscaviarum as causative agent of pulmonary disease is rarely reported even in immunocompromised individuals. | Kusugodlu Ramamoorthi Baise Chandrappagouda Pruthvi Neeleshwara Radhakrishna Rao Jayaprakash Belle Kiran Chawla | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，5： | 4 |
| 4 | Bioanalytical methods for metabolomic profiling:Detection of head and neck cancer,including oral cancer显示文摘Metabolomics is an emerging field dealing with the measurement and interpretation of small molecular byproducts of biochemical processes,or metabolites,which can be used to generate profiles from biological samples.Promising for use in pathophysiology,metabolomic profiles give the immediate biological state of a sample.These profiles are altered in diseases and are detectable in biological samples,such as tissue,blood,urine,saliva,and others.Most remarkably,metabolic profiles usually are altered before symptoms appear in a patient.For this reason,metabolomics has potential as a reliable method for an early diagnosis of diseases through disease biomarker identification.This application is most prevalent in cancer,such as head and neck cancer(HNC).Metabolomic studies offer avenues to improve on current medical techniques through the application of mass spectrometry(MS),nuclear magnetic resonance spectroscopy(NMR),and statistical analysis to determine better biomarkers than those currently known.In this review,we discuss the use of MS and NMR tools for detecting biomarkers in tissue and fluid samples,and the appropriateness of metabolomics in analyzing cancer.Advantages,disadvantages,and recent studies on metabolomic profiling techniques in HNC analysis are also discussed herein. | Nirbhay S.Jain Ulrich H.N.Drr Ayyalusamy Ramamoorthy | 2015 | Chinese Chemical Letters2015，26，4： | 3 |
| 5 | The amazing potential of fungi:50 ways we can exploit fungi industrially显示文摘Fungi are an understudied,biotechnologically valuable group of organisms.Due to the immense range of habitats that fungi inhabit,and the consequent need to compete against a diverse array of other fungi,bacteria,and animals,fungi have developed numerous survival mechanisms.The unique attributes of fungi thus herald great promise for their application in biotechnology and industry.Moreover,fungi can be grown with relative ease,making production at scale viable.The search for fungal biodiversity,and the construction of a living fungi collection,both have incredible economic potential in locating organisms with novel industrial uses that will lead to novel products.This manuscript reviews fifty ways in which fungi can potentially be utilized as biotechnology.We provide notes and examples for each potential exploitation and give examples from our own work and the work of other notable researchers.We also provide a flow chart that can be used to convince funding bodies of the importance of fungi for biotechnological research and as potential products.Fungi have provided the world with penicillin,lovastatin,and other globally significant medicines,and they remain an untapped resource with enormous industrial potential. | Kevin D.Hyde Jianchu Xu Sylvie Rapior Rajesh Jeewon Saisamorn Lumyong Allen Grace T.Niego Pranami D.Abeywickrama Janith V.S.Aluthmuhandiram Rashika S.Brahamanage Siraprapa Brooks Amornrat Chaiyasen K.W.Thilini Chethana Putarak Chomnunti Clara Chepkirui Boontiya Chuankid Nimali I.de Silva Mingkwan Doilom Craig Faulds Eleni Gentekaki Venkat Gopalan Pattana Kakumyan Dulanjalee Harishchandra Hridya Hemachandran Sinang Hongsanan Anuruddha Karunarathna Samantha C.Karunarathna Sehroon Khan Jaturong Kumla Ruvishika S.Jayawardena Jian-Kui Liu Ningguo Liu Thatsanee Luangharn Allan Patrick G.Macabeo Diana S.Marasinghe Dan Meeks Peter E.Mortimer Peter Mueller Sadia Nadir Karaba N.Nataraja Sureeporn Nontachaiyapoom Meghan O’Brien Watsana Penkhrue Chayanard Phukhamsakda Uma Shaanker Ramanan Achala R.Rathnayaka Resurreccion B.Sadaba Birthe Sandargo Binu C.Samarakoon Danushka S.Tennakoon Ramamoorthy Siva Wasan Sriprom T.S.Suryanarayanan Kanaporn Sujarit Nakarin Suwannarach Thitipone Suwunwong Benjarong Thongbai Naritsada Thongklang Deping Wei S.Nuwanthika Wijesinghe Jake Winiski Jiye Yan Erandi Yasanthika Marc Stadler | 2019 | Fungal Diversity2019，，4： | 3 |
| 6 | Studies on anticancer activities of antimicrobial peptides显示文摘 | David W. Hoskin Ayyalusamy Ramamoorthy | 2007 | BBA - Biomembranes2007，，2： | 2 |
| 7 | Evidence for colorectal sarcomatoid carcinoma arising from tubulovillous adenoma显示文摘Sarcomatoid carcinomas of the colorectum are rare tu- mors that display both malignant epithelial and stromal components. Clinically, they are aggressive tumors with early metastasis. Due to their infrequent occurrence, the pathogenesis is poorly understood. We report a case of a 52-year-old woman who presented with a rectal mass and intermittent hematochezia. Superficial biopsies during colonoscopy revealed a tubulovillous adenoma with high-grade dysplasia. Endoscopic ultra- sonography confirmed an invasive nature of the mass, and deeper biopsies revealed the presence of neoplasm with mixed histological components. The surgically- excised specimen demonstrated the presence of poorly differentiated spindle cells underneath the tubulovillous adenoma and an intermediate stage of invasive adeno- carcinoma. Based on the histological appearance and immunohistochemical studies, a diagnosis of sarcoma- toid carcinoma was made. Only nine cases of sarcoma- toid carcinomas of the colorectum have been reported to date. As a result, the terminology and pathogenesis of sarcomatoid carcinoma remain speculative. To the best of our knowledge, this is the first report of co- existence of sarcomatoid carcinoma and invasive ad- enocarcinoma with tubulovillous adenoma; all stages represented within the same tumor. This observation supports the 'monoclonal theory' of pathogenesis with an adenoma-sarcoma progression with or without an intermediate stage of carcinoma. | Jeffrey K Lee Pradipta Ghosh Valerie McWhorter Misty Payne Ryan Olson Mary L Krinsky Sonia Ramamoorthy John M Carethers | 2008 | World Journal of Gastroenterology2008，14，27： | 2 |
| 8 | PCV2疫苗和免疫接种的10年:净化能否成为事实显示文摘在猪圆环病毒2型(Porcine Circovirus type 2,PCV2)出现后的20多年,它仍然是一种对养猪业有重要经济影响的猪病。PCV2的商用疫苗在2006年首次进入美国市场,在减少感染猪的临床症状和提高产量方面起到了显著的作用。最近的研究表明,PCV2在猪场猪群中的流行性和败血症发生率有所下降。然而,新变异毒株的出现又使PCV2的流行性上升。本文将评论PCV2疫苗领域最新热点的话题,包括比较商用疫苗的免疫效果、现有疫苗对新型毒株的免疫效力、自然感染和接种疫苗在免疫力上的差异、目前PCV2疫苗研究模型的局限性以及新型试验疫苗的研究新进展。讨论也是在未来PCV2可得到净化的前提下进行的。 | 刘国民(译) 宋庆庆(校) 林文耀(校) Zahra Afghaha Brett Webbb Xiang-Jin Mengc Sheela Ramamoorthy | 2019 | 国外畜牧学(猪与禽)2019，39，9： | 2 |
| 9 | Studies on anticancer activities of antimicrobial peptides显示文摘 | David W. Hoskin Ayyalusamy Ramamoorthy | 2007 | BBA - Biomembranes2007，，2： | 2 |
| 10 | GABA transmission in the nucleus accumbens is altered after with- drawal from repeated cocaine显示文摘 | Zheng Xiongxi Ramamoorthy S Hui Shen | 2003 | J Neurosci2003，23，8： | 1 |
| 11 | Precomputation-based Rendering 显示文摘 | Ramamoorthi R | 2009 | Foundations and Trends in Computer Graphics and Vision (S1572-2740)2009，3，4： | 1 |
| 12 | A mechano -elec- tro- acoustical model for the cochlea: response to a- coustic stimuli显示文摘 | Ramamoorthy S Deo N V Grosh K | 2007 | Journal of the Acoustical Society of America2007，121，5： | 1 |
| 13 | Brucella melitensis triggers time-dependent modulation of apoptosis and down-regu- lation of mitochondrion-associated gene expression in mouse macrophages显示文摘 | He Y Reiehow S Ramamoorthy S | 2006 | Infect Immun2006，74，9： | 1 |
| 14 | Induction of systemic resistance by plant growth promoting rhizobacteria in crop plants against pests and diseases显示文摘 | Ramamoorthy V Viswanathan R Raguchander T | 2001 | Crop Protection2001，20，1： | 1 |
| 15 | IL-27 promotes T cell-dependent colitis through multiple mechanisms 显示文摘 | Cox JH Kljavin NM Ramamoorthi N ei al | 2011 | J Exp Med2011，208，1： | 1 |
| 16 | Studies on anticancer activities of antimicrobial peptides 显示文摘 | Hoskin DW Ramamoorthy A | 2008 | Biochim Biophys Acta2008，1778，2： | 1 |
| 17 | A look at Spectroscopy显示文摘 | | 2001 | Formation Evaluation Review2001，2，6： | 1 |
| 18 | Development of a Novel High Optical Quality ZnO Thin Films by PLD for III-V Optoelectronic Devices 显示文摘 | Ramamoorthy K Sanjeeviraja G Jayachandran M | 2006 | Current Applied Physics2006，6，1： | 1 |
| 19 | Studies on anticancer activities of antimicrobial peptides 显示文摘 | HOSKIN D W RAMAMOORTHY A | 2008 | Biochim Biophys Acta2008，1778，2： | 1 |
| 20 | Multffunctional host defense peptides: Functional and mechanistic insights from NMR structures of potent antimicrobial peptides显示文摘 | Bhattacharjya Ramamoorthy | 2009 | FEBS2009，276，25： | 1 |
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