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| 1 | Endoscopic extraction of large common bile duct stones:A review article显示文摘Since therapeutic endoscopic retrograde cholangiopancreatography replaced surgery as the first approach in cases of choledocolithiasis,a plethora of endoscopic techniques and devices appeared in order to facilitate rapid,safe and effective bile duct stones extraction.Nowadays,endoscopic sphincterotomy combined with balloon catheters and/or baskets is the routine endoscopic technique for stone extraction in the great majority of patients.Large common bile duct stones are treated conventionally with mechanical lithotripsy,while the most serious complication of the procedure is 'basket and stone impaction' that is predominately resolved surgically.In cases of difficult,impacted,multiple or intrahepatic stones,more sophisticated procedures have been used.Electrohydraulic lithotripsy and laser lithotripsy are performed using conventional mother-baby scope systems,ultra-thin cholangio-scopes,thin endoscopes and ultimately using the novel single use,single operator SpyGlass Direct Visualization System,in order to deliver intracorporeal shock wave energy to fragment the targeted stone,with very good outcomes.Recently,large balloon dilation after endoscopic sphincterotomy confirmed its effectiveness in the extraction of large stones in a plethora of trials.When compared with mechanical lithotripsy or with balloon dilation alone,it proved to be superior.Moreover,dilation is an ideal alternative in cases of altered anatomy where access to the papilla is problematic.Endoscopic sphincterotomy followed by large balloon dilation represents the onset of a new era in large bile duct stone extraction and the management of 'impaction' because it seems that is an effective,inexpensive,less traumatic,safe and easy method that does not require sophisticated apparatus and can be performed widely by skillful endoscopists.When complete extraction of large stones is unsuccessful,the drainage of the common bile duct is mandatory either for bridging to the final therapy or as a curative therapy for very elderly patients with short life expectancy.Placing of more than one plastic endoprostheses is better while the administration of Ursodiol is ineffective.The great majority of patients with large stones can be treated endoscopically.In cases of unsuccessful stone extraction using balloons,baskets,mechanical lithotripsy,electrohydraulic or laser lithotripsy and large balloon dilation,the patient should be referred for extracorporeal shock wave lithotripsy or a percutaneous approach and finally surgery. | Gerasimos Stefanidis Christos Christodoulou Spilios Manolakopoulos Ram Chuttani | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，5： | 23 |
| 2 | Effectiveness of circumferential endoscopic mucosal resection with a novel tissue-anchoring device显示文摘AIM: To evaluate the efficacy of circumferential endoscopic mucosal resection (EMR) with a tissue-anchoring device in comparison to forceps precut EMR and conventional endoscopic submucosal dissection (ESD). METHODS: The study was designed as a prospective, randomized, ex vivo study. Fresh ex vivo specimens were harvested from adult white Yorkshire pigs weighing 30-50 kg. Seventy-five standardized, artificial lesions measuring 3 cm × 3 cm were created by methy- lene blue tattoo at the greater curvature in fresh ex vivo stomachs using the EASIE-R simulator platform (Endosim LLC, Berlin, MA, United States). The three advanced endoscopists performed the three resection techniques such as circumferential EMR using the tissue-anchoring device (TA-EMR), forceps precut EMR (FP-EMR), and endoscopic submucosal dissection. The endoscopists and the type of cutting methods were determined randomly by grouped randomized selection.The resection bed was grossly inspected to determine whether the lesion was resected 'en-bloc ' (defined as no remaining mucosal tattoo remaining on specimen). The resection bed was also probed for evidence of perforation. The procedural time of circumferential resection, submucosal dissection, and injection frequency were recorded by an independent observer.RESULTS: All 75 created lesions were successfully resected by three advanced endoscopists using the three techniques. The mean ± SD size of resected specimens (long axis) were 39.5 ± 5.6 mm, 36.5 ± 7.3 mm, and 44.6 ± 5.6 mm for TA-EMR, FP-EMR, and ESD respectively. The overall mean dissection time of both the TA- EMR and FP-EMR was significant shorter than ESD (TA- EMR: 5.1 ± 3.3 min, FP-EMR: 3.5 ± 2.0 min vs ESD: 15.8 ± 9.5 min, P < 0.001, P < 0.001). The overall mean total procedure time of both the tissue-anchoring and forceps circumferential EMR was significantly shorter than ESD (TA-EMR: 17.5 ± 6.0 min, FP-EMR: 16.6 ± 6.6 min vs ESD: 28.6 ± 13.9 min, P < 0.001, P < 0.001). The en-bloc resection rate of ESD was 100% (25/25) and the en-bloc resection rate of the TA-EMR (84.0%, 21/25) was higher than for the FP-EMR (60.0%, 15/25), yet not statistically significant (P = 0.18). The perforation rate of each technique was 8.0% (2/25). CONCLUSION: TA-EMR appears to be quicker than ESD, and there was a trend towards improved en bloc resection rate with the TA-EMR when compared to the FP-EMR. | Yunho Jung Masayuki Kato Jongchan Lee Mark A Gromski Ram Chuttani Kai Matthes | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，6： | 3 |
| 3 | Covered Wallstents for palliation of malignant biliary obstruction: primary stent placement versus reintervention显示文摘 | Laura C. Ornellas Gerasimos Stefanidis Ram Chuttani Andres Gelrud T. Barry Kelleher Douglas K. Pleskow | 2009 | Gastrointestinal Endoscopy2009，，： | 2 |
| 4 | The learning curve for endoscopic submucosal dissection in an established experimental setting显示文摘 | Masayuki Kato Mark Gromski Yunho Jung Ram Chuttani Kai Matthes | 2013 | Surgical Endoscopy2013，，1： | 1 |
| 5 | The acute and long-term effect of balloon sphincteroplasty on papillary structure in pigs显示文摘 | Padraic Mac Mathuna David Siegenberg David Gibbons Daniel Gorin Michael O’Brien Nezem A. Afdhal Ram Chuttani | 1996 | Gastrointestinal Endoscopy1996，，6： | 1 |
| 6 | Evaluation of recombinant platelet-activating factor acetylhydrolase for reducing the incidence and severity of post-ERCP acute pancreatitis显示文摘 | Stuart Sherman Waleed M. Alazmi Glen A. Lehman Joseph E. Geenen Ram Chuttani Richard A. Kozarek William D. Welch Sonia Souza John Pribble | 2009 | Gastrointestinal Endoscopy2009，，3： | 1 |
| 7 | Comparison of carcinoembryonic antigen and molecular analysis in pancreatic cyst fluid显示文摘 | Mandeep S. Sawhney Shiva Devarajan Paul O'Farrel Marcelo S. Cury Rabi Kundu Charles M. Vollmer Alphonso Brown Ram Chuttani Douglas K. Pleskow | 2009 | Gastrointestinal Endoscopy2009，，6： | 1 |
| 8 | ASGE Technology Status Evaluation Report: wireless capsule endoscopy显示文摘 | Daniel S. Mishkin Ram Chuttani Joseph Croffie James DiSario Julia Liu Raj Shah Lehel Somogyi William Tierney Louis M. Wong Kee Song Bret T. Petersen | 2006 | Gastrointestinal Endoscopy2006，，4： | 1 |
| 9 | Ameta-analysis on efficacy and safety:single-balloon vs.double-balloon enteroscopy显示文摘Background and aim:Double-balloon enteroscopy(DBE)and single-balloon enteroscopy(SBE)are new techniques capable of providing deep enteroscopy.Results of individual studies comparing these techniques have not been able to identify a superior strategy.Our aim was to systematically pool all available studies to compare the efficacy and safety of DBE with SBE for evaluation of the small bowel.Methods:Databases were searched,including PubMed,Embase,and the Cochrane Central Register of Controlled Trials.The main outcome measures were complete small-bowel visualization,diagnostic yield,therapeutic yield,and complication rate.Statistical analysis was performed using Review Manager(RevMan version 5.2).Meta-analysis was performed using fixed-effect or random-effect methods,depending on the absence or presence of significant heterogeneity.We used the v2 and I2 test to assess heterogeneity between trials.Results were expressed as risk ratios(RR)or mean differences with 95%confidence intervals(CI).Results:Four prospective,randomized,controlled trials with a total of 375 patients were identified.DBE was superior to SBE for visualization of the entire small bowel[pooled RR=0.37(95%CI:0.19–0.73;P=0.004)].DBE and SBE were similar in ability to provide diagnosis[pooled RR=0.95(95%CI:0.77–1.17;P=0.62)].There was no significant difference between DBE and SBE in therapeutic yield[pooled RR=0.78(95%CI:0.59–1.04;P=0.09)]and complication rate[pooled RR=1.08(95%CI:0.28–4.22);P=0.91].Conclusions:DBE was superior to SBE with regard to complete small bowel visualization.DBE was similar to SBE with regard to diagnostic yield,ability to provide treatment and complication rate,but these results should be interpreted with caution as they is based on very few studies and the overall quality of the evidence was rated as low tomoderate,due to the small sample size. | Vaibhav Wadhwa Saurabh Sethi Sumeet Tewani Sushil Kumar Garg Douglas K.Pleskow Ram Chuttani Tyler M.Berzin Nidhi Sethi Mandeep S.Sawhney | 2015 | Gastroenterology Report2015，3，2： | 1 |
| 10 | Propofol versus traditional sedative agents for advanced endoscopic procedures: A meta‐analysis显示文摘 | Saurabh Sethi Vaibhav Wadhwa Adarsh Thaker Ram Chuttani Douglas K. Pleskow Sheila R. Barnett Daniel A. Leffler Tyler M. Berzin Nidhi Sethi Mandeep S. Sawhney | 2014 | Digestive Endoscopy2014，，4： | 1 |
| 11 | Direct visualization of indeterminate pancreaticobiliary strictures with probe-based confocal laser endomicroscopy: a multicenter experience显示文摘 | Alexander Meining Yang K. Chen Douglas Pleskow Peter Stevens Raj J. Shah Ram Chuttani Joel Michalek Adam Slivka | 2011 | Gastrointestinal Endoscopy2011，，5： | 1 |
| 12 | Balloon-based, circumferential, endoscopic radiofrequency ablation of Barrett’s esophagus: 1-year follow-up of 100 patients (with video) <ce:link locator='fx1'/>显示文摘 | Virender K. Sharma Kenneth K. Wang Bergein F. Overholt Charles J. Lightdale M. Brian Fennerty Patrick J. Dean Douglas K. Pleskow Ram Chuttani Alvaro Reymunde Nilda Santiago Kenneth J. Chang Michael B. Kimmey David E. Fleischer | 2007 | Gastrointestinal Endoscopy2007，，2： | 1 |
| 13 | Balancing risk and reward: a critical review of the intragastric balloon for weight loss显示文摘 | Shantanu Gaur Samuel Levy Lisbeth Mathus-Vliegen Ram Chuttani | 2015 | Gastrointestinal Endoscopy2015，，6： | 1 |
| 14 | Tissue adhesives and fibrin glues显示文摘 | Bret Petersen Alan Barkun Steven Carpenter Poonputt Chotiprasidhi Ram Chuttani William Silverman Nadem Hussain Julia Liu Greta Taitelbaum Gregory G. Ginsberg | 2004 | Gastrointestinal Endoscopy2004，，3： | 1 |
| 15 | Intraductal US is a useful adjunct to ERCP for distinguishing malignant from benign biliary strictures显示文摘 | Richard J. Farrell Banke Agarwal Steven L. Brandwein John Underhill Ram Chuttani Douglas K. Pleskow | 2002 | Gastrointestinal Endoscopy2002，，： | 1 |
| 16 | Endoscopic clip application devices显示文摘 | Ram Chuttani Alan Barkun Steven Carpenter Poonputt Chotiprasidhi Gregory G. Ginsberg Nadeem Hussain Julia Liu William Silverman Greta Taitelbaum Bret Petersen | 2006 | Gastrointestinal Endoscopy2006，，6： | 1 |
| 17 | Sclerosing agents for use in GI endoscopy显示文摘 | Joseph Croffie Lehel Somogyi Ram Chuttani James DiSario Julia Liu Daniel Mishkin Raj J. Shah William Tierney Louis M. Wong Kee Song Bret T. Petersen | 2007 | Gastrointestinal Endoscopy2007，，1： | 1 |
| 18 | The acute and long-term effect of balloon sphincteroplasty on papillary structure in pigs显示文摘 | Padraic Mac Mathuna David Siegenberg David Gibbons Daniel Gorin Michael O’Brien Nezem A. Afdhal Ram Chuttani | 1996 | Gastrointestinal Endoscopy1996，，6： | 1 |
| 19 | Effect of Institution-Wide Policy of Colonoscopy Withdrawal Time ≥7 Minutes on Polyp Detection显示文摘 | Mandeep S. Sawhney Marcelo S. Cury Naama Neeman Long H. Ngo Janet M. Lewis Ram Chuttani Douglas K. Pleskow Mark D. Aronson | 2008 | Gastroenterology2008，，6： | 1 |
| 20 | Is CT angiography sufficient for prediction of resectability of periampullary neoplasms?显示文摘 | Pierre F. Saldinger M.D. Melissa Reilly R.N. Kevin Reynolds M.D. Vassilios Raptopoulos M.D. Ram Chuttani M.D. Michael L. Steer M.D. Jeffrey B. Matthews M.D | 2000 | Journal of Gastrointestinal Surgery2000，，3： | 1 |
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