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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | Transport of metal ions across an electrically switchable cation exchange membrane based on polypyrrole doped with a sulfonated calyx arene 显示文摘 | Akich M N Ralph S F Bobacka J | 2010 | J Membrane Sci2010，354，： | 1 |
| 3 | Effect of dietary fat and cholesterol on the in vitro incorporation of acetate-14C into hen liver and ovarian lipids 显示文摘 | JOSEPH F W EDWARD C N RALPH M J | 1967 | The Journal of Nutrition1967，93，： | 1 |
| 4 | Transplanted suprachiasmatic nucleus determines circadian period显示文摘 | Ralph M R Foster R G Davis F C | 1990 | Science1990，247，4945： | 1 |
| 5 | Precipitation identification from radar wind profiler spectral moment data: Vertical velocity histograms, velocity variance, and signal power-vertical velocity correlations显示文摘 | Ralph F M Neiman P J Uffieux D | 1995 | J Atmos Oceanic Technol1995，13，： | 1 |
| 6 | Antiviral activities of biflavonoids显示文摘 | LI Y M Michael T F Ralph S | 1999 | Planta Med1999，65，： | 1 |
| 7 | Use of information by National Weather Service forecasters and emergency managers during CALJET and PACJET-2001显示文摘 | Morss R E Ralph F M | | 0，，3： | 1 |
| 8 | Dropsonde observations in low-level jets over the northeastern pacific ocean from CALJET- 1998 and PACJET-2001 : Mean vertical-profile and atmosphericriver characteristics显示文摘 | Ralph F M Neiman P J Rotunno R | 2005 | Monthly Weather Review2005，133，： | 1 |
| 9 | History and evolution of antibiotic resistance in coagulase-negative staphylococci : susceptibili- ty profiles of new anti-staphylococcal agents显示文摘 | JOSEPH F J ALEXANDER M H RALPH H J | 2007 | Ther Clin Risk Man- ag2007，，36： | 1 |
| 10 | A close look at loeoweed poisoning on short grass prairies 显示文摘 | Ralphs M H Graham J D James L F | 2002 | Rangelands2002，24，： | 1 |
| 11 | Satellite and CALJET aircraft observations of atmospheric rivers over the eastern North Pacific Ocean during the winter of 1997/98显示文摘 | Ralph F M Neiman P J Wick G A | 2004 | Monthly Weather Re- view2004，132，7： | 1 |
| 12 | Me- teorological characteristics and overland precipita- tion impacts of atmospheric rivers affecting the west coast of North America based on eight years of SSM/I satellite observations 显示文摘 | Neiman P J Ralph F M Wick G A | 2008 | Monthly Weather Review2008，9，1： | 1 |
| 13 | Diag- nosis of an intense atmospheric river impacting the Pacific Northwest: Storm summary and off- shore vertical structure observed with COSMIC satellite retrievals 显示文摘 | Neiman P J Ralph F M Wick G A | 2008 | Monthly Weather Review2008，136，11： | 1 |
| 14 | Combined ingestion of protein and free leucine with carbohydrate increases postexercise muscle protein synthesis in vivo in male subjects显示文摘 | RENE KOOPMAN ANTON J M WAGENMAKERS RALPH J F MANDERS | 2005 | Am J Physiol Endocfinol Metab2005，288，： | 1 |
| 15 | Assimilation of GPS radio occultation data for an intense atmo- spheric river with the NCEP regional GSI system 显示文摘 | Ma Z Kuo Y H Ralph F M | 2011 | Monthly Weather Review2011，139，7： | 1 |
| 16 | Physical processes associated with heavy flooding rainfall in Nashville, Tennessee, and Vicinity during 1 - 2 May 2010 : The role of an atmospher- ic river and Mesoscale Convective Systems 显示文摘 | Moore B J Neiman P J Ralph F M | 2012 | Monthly Weather Review2012，140，2： | 1 |
| 17 | Lignins and ferulate- coniferyl alcohol cross - coupling products in cereal grains 显示文摘 | Bunzel M Ralph J Lu F | 2004 | Journal of Agricultural and Food Chemistry2004，52，21： | 1 |
| 18 | Locoweed grazing显示文摘 | Ralphs M H James L F | 1999 | Journal of Natural Toxins1999，，8： | 1 |
| 19 | Chlorobenzene induces oxidative stress in human lung epithelial cells in vitro 显示文摘 | RALPH F ILJANA M CARMEN R S | 2010 | Toxicology and Applied Pharmaco|ogy2010，242，： | 1 |
| 20 | Storms, floods and the science of at- mospheric rivers显示文摘 | Ralph F M Dettinger M D | 2011 | Eos Trans Amer Geophys Union2011，92，： | 1 |
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