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| 1 | Therapeutic effects of tender coconut water on oxidative stress in fructose fed insulin resistant hypertensive rats显示文摘Objective:To investigate whether tender coconut water(TCW) mitigates oxidative stress in fructose fed hypertensive rats.Methods:Male Sprague Dawley rats were fed with fructose rich diet and treated with TCW(4 mL/100 g of body weight) for 3 subsequent weeks.Systolic blootl pressure was measured every three days using the indirect tail cuff method.At the end of the experimental period,plasma glucose and insulin,serum triglycerides and free fatly acids, lipid peroxidation markers(MDA,hydroperoxides and conjugated dienes) and the activities of antioxidant enzymes were analyzed in all the groups.Results:Treatment with TCW significandy lowered the systolic blood pressure and reduced serum triglycerides and free fatty acids.Plasma glucose and insulin levels and lipid peroxidation markers such as MDA,hydroperoxides and conjugated dienes were significantly reduced in fructose fed rats treated with TCW.Activities of antioxidant enzymes are up regulated significantly in TCW treated rats.Hislopathological analysis of liver showed that TCW treatment reduced the lipid accumulation and inflammatory infiltration without any significant hepatocellular damage.Conclusions:The overall results suggest that, TCW treatment could prevent and reverse high blood pressure induced by high fructose diet probably by inhibition of lipid peroxidation,upregulation of antioxidant status and improved insulin sensitivity. | D Bhagya L Prema T Rajamohan | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，4： | 2 |
| 2 | Pokeweed antiviral protein isoforms PAP-I, PAP-II, and PAP-III depurinate RNA of human immunodeficiency virus(HIV)-I 显示文摘 | Rajamohan F Venkatachalam T K Irvin J D | 1999 | Biochem Biophys Res Commun1999，260，2： | 1 |
| 3 | Pokeweed antiviral protein isoforms PAP-Ⅰ, PAP-Ⅱ, and PAP-Ⅲ depurinate RNA of human immunodeficiency virus (HIV)-1 显示文摘 | RAJAMOHAN F VENKATACHALAM T K IRVIN J D | 1999 | Biochem Biophys Res Commun1999，260，2： | 1 |
| 4 | Deguanylation of human immuno-deficiency virus (HIV-1)RNA by recombinant pokeweed antiviral protein 显示文摘 | Rajamohan F Kurinov I V Venkatachalam T K | 1999 | Biochem Biophys Res Commun1999，263，2： | 1 |
| 5 | Beneficial effects of virgin coconut oil on lipid parameters and in vitro LDL Oxidation 显示文摘 | K G Nevin T Rajamohan | 2004 | Clinical Biochemistry2004，37，： | 1 |
| 6 | Virgin coconut oil supplemented diet increase the antioxidation status in rats 显示文摘 | K G Nevin T Rajamohan | 2006 | Food Chemistry2006，99，： | 1 |
| 7 | Beneficial effects of virgin coconut oil on lipid paramaters and in vitro LDL oxidation显示文摘 | K G Nevin T Rajamohan | 2004 | Clinical Biochemistry2004，37，： | 1 |
| 8 | Beneficial effects of virgin coconut oil on lipid parameters and in vitro LDL oxidation 显示文摘 | NEVIN K G RAJAMOHAN T | 2004 | Clinical Biochemistry2004，37，9： | 1 |
| 9 | Virgin coconut oil supplemented diet increase the antioxidation status in rats显示文摘 | K G Nevin T Rajamohan | 2006 | Food Chemistry2006，99，： | 1 |
| 10 | Beneficial effects of virgin coconut oil on lipid parameters and in vitro LDL Oxidation 显示文摘 | K G Nevin T Rajamohan | 2004 | Clinical Biochemistry2004，37，： | 1 |
| 11 | High-level expression and purification of biologically active recombinant pokeweed antiviral protein 显示文摘 | Rajamohan F Engstrom C R Denton T J | 1999 | Protein Expr Purif1999，16，2： | 1 |
| 12 | Beneficial effects of virgin coconut oil on lipid parameters and in vitro LDL oxidation 显示文摘 | Nevin K G Rajamohan T | 2004 | Clinical Biochemistry2004，37，5： | 1 |
| 13 | Effect of topical appli- cation of virgin coconut oil on skin components and antioxidant status during dermal wound heal- ing in young rats 显示文摘 | Nevin K G Rajamohan T | 2010 | Skin Pharmacology and Physiology2010，23，6： | 1 |
| 14 | Beneficial effects of virgin coconut on lipid parameters and in vitro LDL oxidation显示文摘 | Nevin K G Rajamohan T | 2004 | Clinical pchemistry2004，37，5： | 1 |
| 15 | Beneficial effects of virgin coconut oil on lipid parameters and in vitro LDL Oxidation显示文摘 | Nevin K G Rajamohan T | 2004 | Clinical Biochemistry2004，37，： | 1 |
| 16 | Comparative evaluation of the hypolipidemic effects of coconut water and lovastatin in rats fed fat-cholesterol enriched diet 显示文摘 | SANDHYA V G RAJAMOHAN T | 2008 | Food Chem Toxicol2008，46，12： | 1 |
| 17 | Virgin coconut oil supple-mented diet increase the antioxidation status in rats 显示文摘 | Nevin KG Rajamohan T | 2006 | Food Chemistry2006，99，： | 1 |
| 18 | Wet and dry extraction of coconut oil: impact on lipid metabolic and an- tioxidant status in cholesterol coadministered rats 显示文摘 | Nevin K G Rajamohan T | 2009 | Canadian Journal of Physiology and Pharmacology2009，87，8： | 1 |
| 19 | Hypolipidemic effect of hemicellutoses component of coconut fiber显示文摘 | Sindhurani J A Rajamohan T | 1998 | Indian J Exp Biol1998，36，8： | 1 |
| 20 | Virgin coconut oil improves hepatic lipid metabolism in rats - compared with copra oil, olive oil and sunflower oil 显示文摘 | ARUNIMA S RAJAMOHAN T | 2012 | Ind J Exp Biol2012，50，11： | 1 |
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