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| 1 | Predicting asymptomatic coronary artery stenosis by aortic arch plaque in acute ischemic cerebrovascular disease:beyond the cervicocephalic atherosclerosis?显示文摘Background:Asymptomatic coronary artery stenosis(ACAS)≥50%is common in patients with acute ischemic cerebrovascular disease(AICVD),which portends a poor cardiovascular and cerebrovascular prognosis.Identifying ACAS>50%early may optimize the clinical management and improve the outcomes of these high-risk AICVD patients.This study aimed to investigate whether aortic arch plaque(AAP),an early atherosclerotic manifestation of brain blood-supplying arteries,could be a predictor for ACAS>50%in AICVD.Methods:In this cross-sectional study,atherosclerosis of the coronary and brain blood-supplying arteries was simultaneously evaluated using one-step computed tomography angiography(CTA)in AICVD patients without coronary artery disease history.The patients were divided into ACAS≥50%and non-ACAS≥50%groups according to whether CTA showed stenosis≥50%in at least one coronary arterial segment.The AAP characteristics of CTA were depicted from aspects of thickness,extent,and complexity.Results:Among 118 analyzed patients with AICVD,29/118(24.6%)patients had ACAS≥50%,while AAPs were observed in 86/118(72.9%)patients.Increased AAP thickness per millimeter(adjusted odds ratio[OR]:1.56,95%confidence interval[CI]:1.18-2.05),severe-extent AAP(adjusted OR:13.66,95%CI:2.33-80.15),and presence of complex AAP(adjusted OR:7.27,95%CI:2.30-23.03)were associated with ACAS≥50%among patients with AICVD,independently of clinical demographics and cervicocephalic atherosclerotic stenosis.The combination of AAP thickness,extent,and complexity predicted ACAS≥50%with an area under the receiver-operating characteristic curve of 0.78(95%CI:0.70-0.85,P<0.001).All three AAP characteristics provided additional predictive power beyond cervical and intracranial atherosclerotic stenosis for ACAS≥50%in AICVD(all P<0.05).Conclusions:Thicker,severe-extent,and complex AAP were significant markers of the concomitant ACAS≥50%in AICVD,possibly superior to the indicative value of cervical and intracranial atherosclerotic stenosis.As an integral part of atherosclerosis of brain blood-supplying arteries,AAP should not be overlooked in predicting ACAS≥50%for patients with AICVD. | Xin Ma Qi Kong Chen Wang Gary Rajah Yu-Chuan Ding Yu-Ren Zhang Xiang-Ying Du | 2019 | Chinese Medical Journal2019，，8： | 13 |
| 2 | Information, contracting and quality costs 显示文摘 | Baiman S Fischer P E Rajah M V | 2000 | Management Science2000，46，6： | 1 |
| 3 | Genistein in the presence of 17beta-estradiol inhibits proliferation of ERbeta breast cancer cells显示文摘 | RAJAH T T D U N DREWS N | 2009 | Pharmacology2009，84，2： | 1 |
| 4 | Cycle-proof Regulation显示文摘 | Raghuram Rajah | 2009 | The Economist (Print Edition)2009，，8： | 1 |
| 5 | Biological changes associated with healthy versuspathological aging: a symposium review 显示文摘 | Rajah MN Bastianetto S Bromley-Brits K etal | 2009 | Ageing Res Rev2009，8，2： | 1 |
| 6 | 7s Nerve growth factor is an insulin-like growth factor-binding protein protease 显示文摘 | Rajah R Bhala A Nunn SE | 1996 | Endocrinology1996，137，6： | 1 |
| 7 | Comparison of mixed antiglobulin reaction and direct immunobead test for detection of sperm-bound antibodies in subfertil males显示文摘 | Rajah SV Parslow JM Howell RJ | 1992 | Fertil Steril1992，57，6： | 1 |
| 8 | The inhibitory effect of ghrelin on sepsis-induced inflammation is mediated by the MAPK phosphatase-l显示文摘 | Jacob A Rajah D Pathickal B | 2010 | Int J Mol Med2010，25，1： | 1 |
| 9 | Insulin-like growth factor (IGF)-binding protein--3 induces apoptosis and mediates the effects of transforming growth factor-betal an programmed cell death through a p53- and IGF- independent mechanism显示文摘 | Rajah R Valentinis B Cohen P | 1997 | J Biol Chem1997，272，12： | 1 |
| 10 | Fullscalel structu ral monitoring using an in tegrated GPS andaccelerom eter sy stem显示文摘 | Li Xiaojing Ge Linlin E li athamby Ambik ai rajah | 2006 | GPS Solu tions2006，10，： | 1 |
| 11 | Elevated levels of the IGF binding protein protease MMP1 in asthmatic airway smooth muscle显示文摘 | Rajah R Nachajon RV Collins MH | 1999 | Am J Respir Cell Mol Biol1999，20，： | 1 |
| 12 | Comparative study of ankle arthrodesis using cross screw fLxation versus anterior contoured plate plus cross screw fixation显示文摘 | Kakarala G Rajah DT | 2006 | Acta Orthop Belg2006，6，： | 1 |
| 13 | Postpartum hemorrhage: evidence-based med- ical interventions for prevention and treatment 显示文摘 | Rajah P V Wing D A | 2010 | Clin Obstet Gynecol2010，53，1： | 1 |
| 14 | Clinical endocriologic and ultrasonographic features of polycystic ovary syndrome in Singaporean adolescents显示文摘 | Gob VH Rajah U | 1997 | J Pediat Adoles Gynecol1997，10，3： | 1 |
| 15 | The Stochastic Queue- Center Problem 显示文摘 | Jami I Mamnoon Alok Baveja & Rajah Batta | 1999 | Computers & Operations Research1999，26，14： | 1 |
| 16 | Financial Dependence and Growth 显示文摘 | Rajah R G Zingles L | 1998 | The American Economic Review1998，88，3： | 1 |
| 17 | Early Experience With Laparoscopic Radical Gastrectomy for Advanced Gastric Cancer显示文摘 | Peter M. Y. Goh Ameer Z. Khan Jimmy B. Y. So David Lomanto Wei-Keat Cheah Rajah Muthiah Anil Gandhi | 2001 | Surgical Laparoscopy, Endoscopy & Percutaneous Te2001，，2： | 1 |
| 18 | Transaortic repair of ruptured aneurysm of sinus of valsalva显示文摘 | Hamid IA Jothi M Rajah S | 1994 | J Thorac Cardiovasc Surg1994，107，6： | 1 |
| 19 | The cost of diversi- ty:The diversification discount and inefficient invest- ment 显示文摘 | Rajah R Servaes H Zingales L | 2000 | The Journal of Finance2000，55，1： | 1 |
| 20 | The Cost of Diversity: The Diversification Discount and Inefficient Investment 显示文摘 | Raghuram Rajah Henri Servaes Luigi Zingales | 2000 | The Journal of Finance2000，2，1： | 1 |
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