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| 1 | Urinary nuclear magnetic resonance spectroscopy of a Bangladeshi cohort with hepatitis-B hepatocellular carcinoma: A biomarker corroboration study显示文摘AIM: To establish if a distinct urinary metabolic profile could be identified in Bangladeshi hepatitis-B hepatocellular carcinoma(HCC) patients compared to cirrhosis patients and controls. METHODS: Urine samples from 42 Bangladeshi patients with HCC(39 patients with hepatitis-B HCC), 47 with cirrhosis on a background of hepatitis B, 46 with chronic hepatitis B, and seven ethnically-matched healthy controls were analyzed using nuclear magnetic resonance(NMR) spectroscopy. A full dietary and medication history was recorded for each subject. The urinary NMR data were analyzed using principal component analysis(PCA) and orthogonal partial leastsquared discriminant analysis(OPLS-DA) techniques. Differences in relative signal levels of the most discriminatory metabolites identified by PCA and OPLSDA were compared between subject groups using an independent samples Kruskal-Wallis one-way analysis of variance(ANOVA) test with all pairwise multiple comparisons. Within the patient subgroups, the MannWhitney U test was used to compare metabolite levels depending on hepatitis B e-antigen(HBe Ag) status and treatment with anti-viral therapy. A BenjaminiHochberg adjustment was applied to acquire the level of significance for multiple testing, with a declared level of statistical significance of P < 0.05.RESULTS: There were significant differences in age(P < 0.001), weight(P < 0.001), and body mass index(P < 0.001) across the four clinical subgroups. Serum alanine aminotransferase(ALT) was significantly higher in the HCC group compared to controls(P < 0.001); serum α-fetoprotein was generally markedly elevated in HCC compared to controls; and serum creatinine levels were significantly reduced in the HCC group compared to the cirrhosis group(P = 0.004). A threefactor PCA scores plot showed clustering of the urinary NMR spectra from the four subgroups. Metabolites that contributed to the discrimination between the subgroups included acetate, creatine, creatinine, dimethyamine(DMA), formate, glycine, hippurate, and trimethylamine-N-oxide(TMAO). A comparison of relative metabolite levels confirmed that carnitine was significantly increased in HCC; and creatinine, hippurate, and TMAO were significantly reduced in HCC compared to the other subgroups. HBe Ag negative patients showed a significant increase in creatinine(P = 0.001) compared to HBe Ag positive patients in the chronic hepatitis B subgroup, whilst HBe Ag negative patients showed a significant decrease in DMA(P = 0.004) in the cirrhosis subgroup compared to HBe Ag positive patients. There were no differences in metabolite levels in HCC patients who did or did not receive antiviral treatment. CONCLUSION: Urinary NMR changes in Bangladeshi HCC were identified, corroborating previous findings from Egypt and West Africa. These findings could form the basis for the development of a cost-effective HCC dipstick screening test. | I Jane Cox Abil E Aliev Mary ME Crossey Mahvish Dawood Mamun Al-Mahtab Sheikh M Akbar Salimur Rahman Antonio Riva Roger Williams Simon D Taylor-Robinson | 2016 | World Journal of Gastroenterology2016，22，16： | 4 |
| 2 | Drainage vs. non-drainage after cholecystectomy for acute cholecystitis:a retrospective study显示文摘Many surgeons practice prophylactic drainage after cholecystectomy without reliable evidence,this study was conducted to answer the question whether to drain or not to drain after cholecystectomy for acute calculous cholecystitis.A retrospective review of all patients who had cholecystectomy for acute cholecystitis in Aseer Central Hospital,Abha,Saudi Arabia,was conducted from April 2010 to April 2012.Data were extracted from hospital case files.Preoperative data included clinical presentation,routine investigations and liver function tests.Operative data included excessive adhesions,bleeding,bile leak,and drain insertion.Complicated cases such as pericholecystic collections,mucocele and empyema were also reported.Patients who needed therapeutic drainage were excluded.Postoperative data included hospital stay,volume of drained fluid,time of drain removal,and drain site problems.The study included 103 patients allocated into two groups;group A(n = 38) for patients with operative drain insertion and group B(n = 65) for patients without drain insertion.The number of patients with preoperative diagnosis of acute non-complicated cholecystitis was significantly greater in group B(80%) than group A(36.8%)(P < 0.001).Operative time was significantly longer in group A.All patients who were converted from laparoscopic to open cholecystectomy were in group A.Multivariate analysis revealed that hospital stay was significantly(P < 0.001) longer in patients with preoperative complications.There was no added benefit for prophylactic drain insertion after cholecystectomy for acute calculous cholecystitis in non-complicated or in complicated cases. | Mohammed A Bawahab Walid M Abd El Maksoud Saeed A Alsareii Fahad S Al Amri Hala F Ali Abdul Rahman Nimeri Abdul Rahman M Al Amri Adel A Assiri Mohammed I Abdul Aziz | 2014 | The Journal of Biomedical Research2014，28，3： | 3 |
| 3 | Analysis and evaluation of five short-term load forecastingtechniques显示文摘 | Moghram I Rahman S | 1989 | IEEE Trans on Power Systems1989，4，4： | 2 |
| 4 | Fabrication and measurements on polymer bonded Nd-Fe-B magnets显示文摘 | Rahman I Z | 1996 | Journal of Materials Processing Technology1996，56，14： | 1 |
| 5 | High-speed satellite mobile communications:technologies and challenges显示文摘 | Ibnkahla M Rahman Q M Sulyman A I | 2004 | IEEE2004，92，2： | 1 |
| 6 | ' Abasin -95' , a new oilseed rape cultivar developed through induced mutations 显示文摘 | Shah S A Ali I Rahman K | 2001 | Mut Breed Newsletter2001，45，： | 1 |
| 7 | Induction of gamma- glutamylcysteine synthetase by cigarette smoke is associated with AP - 1 in human alveolar epithelial cells显示文摘 | Rahman I Smith CA Lawson MF | 1996 | FEBS Lett1996，396，1： | 1 |
| 8 | 查看详情显示文摘 | Pa N F C Ahmed I Nawawi M G M Rahman W A W A | | 0，，04： | 1 |
| 9 | Molecular mechanism of the regulation of glutathione synthesis by tumor necrosis factor-alpha anddexamethasone in human alveolar epithelial cells显示文摘 | Rahman I Antonicelli F MacNee W | 1999 | J Biol Chem1999，274，8： | 1 |
| 10 | Anti-inflammatory effect of a selective I kappa B kinase-beta inhibitor in rat lung in response to LPS and cigarette smoke显示文摘 | Rajendrasozhan S Hwang JW Yao HA Rahman I | 2010 | Pulm Pharmacol Ther2010，23，3： | 1 |
| 11 | Input variable selection for ANN-based shortterm load forecasting显示文摘 | Drezga I Rahman S | 1998 | IEEE Transactions on Power Systems1998，13，4： | 1 |
| 12 | Role of transcription factors in inflammatory lung disease显示文摘 | Rahman I Macnee W | 1998 | Thorax1998，53，： | 1 |
| 13 | Lung glutathione and oxidative stress: implications in cigarette smoke- induced airway disease显示文摘 | Rahman I Macnee W | 1999 | Am J Physiol1999，277，21： | 1 |
| 14 | Potential virulence of viable but noncalturable Shigella dysenteriae type l显示文摘 | Rahman I Shabamat M Chowdhury M A | 1996 | Appl Environ Microbiol1996，62，1： | 1 |
| 15 | Amniotic membrane in oph- thalmology : indications and limitations 显示文摘 | Rahman I Said DG Maharajan VS | 2009 | Eye ( Lond )2009，23，10： | 1 |
| 16 | Characterisation of γ-glutamylcysteine synthethase- heavy subunit promoter: a critical role for AP-1 显示文摘 | Rahman I Smith C A Antonicelli F | 1998 | FEBS Lett1998，427，1： | 1 |
| 17 | Bioremediation of hydrocarbon pollution using biosurfactant producing oil degrading bacteria显示文摘 | Banat I M Rahman P K S M Rahman T J | 2002 | Water Studies2002，11，9： | 1 |
| 18 | Characterizing the Saltol quantitative trait locus for salinity tolerance in rice 显示文摘 | Thomson M J Ocampo M Egdane J Rahman M A Sajise A G Adorada D L Tumimbang-Raiz E Blumwald E Seraj Z I Singh R K Gregorio G B Ismail A M | 2010 | Rice2010，3，2： | 1 |
| 19 | Analysis and evaluation of five short-term load forecasting techniques显示文摘 | MOGHRAM I RAHMAN S | 1989 | IEEE Transactions onPower Systems1989，4，4： | 1 |
| 20 | Pregnenolone derivatives as potential anticancer agents 显示文摘 | CHOUDHARY M I ALAM M S RAHMAN A | 2011 | Steroids2011，76，14： | 1 |
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