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| 1 | Role of tissue microenvironment resident adipocytes in colon cancer显示文摘Colorectal cancer(CRC) is a multifactorial disease characterized by several genetic and epigenetic alterations occurring in epithelial cells. It is increasingly recognized that tumour progression is also regulated by tumour microenvironment(TME). The bidirectional cross-talk between tumour resident adipocytes and cancer cells within TME has been proposed as active contributor to carcinogenesis. Tumour resident adipocytes exhibit an activated phenotype characterized by increased secretion of pro-tumorigenic factors(angiogenic/inflammatory/immune) which contribute to cancer cell proliferation, invasion, neoangiogenesis, evasion of immune surveillance and therapy resistance. Furthermore, adipocytes represent a fuel rich source for increasing energy demand of rapidly proliferating tumour cells. Interestingly, a relationship between obesity and molecular variants in CRC has recently been identified. Whether adipose tissue promotes cancer progression in subsets of molecular phenotypes or whether local tissue adipocytes are involved in inactivation of tumour suppressor genes and/or activation of oncogenes still needs to be explored. This editorial highlights the major findings related to crosstalk between adipocytes and colon cancer cells and how local paracrine interactions may promote cancer progression. Furthermore, we provide future strategies in studying colonic TME which could provide insights in bidirectional cross-talk mechanisms between adipocytes and colonic epithelial cells. This could enable to decipher critical signalling pathways of both early colonic carcinogenesis and cancer progression. | Maria Tabuso Shervanthi Homer-Vanniasinkam Raghu Adya Ramesh P Arasaradnam | 2017 | World Journal of Gastroenterology2017，23，32： | 6 |
| 2 | A Novel Electrochemical Biosensor Based on Horseradish Peroxidase Immobilized on Ag-nanoparticles/poly(L-arginine)Modified Carbon Paste Electrode Toward the Determination of Pyrogallol/Hydroquinone显示文摘 | Raghu P Madhusudana Reddy T Reddaiah K | 2013 | Enzyme and Microbial Technology2013，52，67： | 1 |
| 3 | Fracture energy and softening behavior of high strength concrete显示文摘 | RAO A G RAGHU P B K | 2002 | Cement and Concrete Research2002，32，2： | 1 |
| 4 | Seasonal phenology of Bactrocera minax (Diptera:Tephritidae) in western Bhutan显示文摘 | Dorji C Clark A R Drew R A I Fletcher B S Loday P Mahat K Raghu S and Roming M C | | 0，，： | 1 |
| 5 | Segmentation of Gabor-filtered textures using deterministic relaxation显示文摘 | P P Raghu B Yegnanarayana | 1996 | IEEE Trans Image Process1996，5，12： | 1 |
| 6 | Synthesis of nancrystanine copper-tungsten alloy by mechanical alloying显示文摘 | Raghu T Sundaresan R Ramakrishnan P | 2001 | Material Science and Engineering A2001，30，4306： | 1 |
| 7 | Sobgel immobi- lized biosensor for the detection of organophosphorous pes- ticidesz a voltammetric method显示文摘 | Raghu P Swamy B E Reddy T M | 2012 | Bioelectrochemistry2012，83，： | 1 |
| 8 | Develop- ment of AChE biosensor for the determination of methyl parathion and monocrotophos in water and fruit samples:A cyclic voltammetric, study 显示文摘 | Raghu P Madhusudana R T Kumara B E | 2012 | Journal of Electroanalytical Chemistry2012，665，： | 1 |
| 9 | Synthesis of nanocrystalline copper-tungsten alloys by mechanical alloying显示文摘 | Raghu T Sundaresan R Ramakrishnan P | 2001 | Materials Science and Engineering A2001，304，： | 1 |
| 10 | Idiopathic dilatation of the pulmonary artery-a case report显示文摘 | Kharge J Singh A P Raghu T R | 2013 | Echocardiography2013，30，9： | 1 |
| 11 | Schizophrenia and the cultural epidemiology of stigma in Bangalore,India显示文摘 | Raguram R Raghu TM Vounatsou P | 2004 | J Nerv Ment Dis2004，192，11： | 1 |
| 12 | Identification of drugs in pharmaceutical dosage forms by X-ray powder diffractometry 显示文摘 | NEELIMA V P RAGHU K C RAJ S | 1997 | J Pharm Biomed Anal1997，15，7： | 1 |
| 13 | Sol- Gel Immobilized Biosensor for the Detection of Organophosphorous Pesticides : A Voltammetric Method 显示文摘 | Raghu P Kumara Swamy B E Madhusudana Reddy T | 2012 | Bioeleetroc hemistry2012，83，1： | 1 |
| 14 | Observation of two stage dislocation dynamics from nonlinear ulirasonie response during the plastic deformation of AA7175-T7351 aluminum alloy显示文摘 | JAYA R V V S ELANKUMAR ANI K RAGHU V P | 2009 | Materials Science and Engineering A2009，512，12： | 1 |
| 15 | Synthesis of nanocrystalline copper -tungsten alloys by mechanical alloying显示文摘 | Raghu T Sundaresan R Ramakrishnan P | 2001 | Materials Science and Engineering A2001，，304306： | 1 |
| 16 | Effect of styrene-isoprenestyrene, styrene-butadiene-styrene, and styrene-butadienerubber on the mechanical, thermal, rheological, and morphological properties of polypropylene/polystyrene blends 显示文摘 | Raghu P Nere C K Jagtap R N | 2003 | J Appl polym Sci2003，88，2： | 1 |
| 17 | Aeetyleholines- terase based biosensor for monitoring of Malathion and Aeephate in food samples ~ A voltammetrie study 显示文摘 | Raghu P Reddy T M Reddaiah K | 2014 | Food Chem2014，142，： | 1 |
| 18 | Dimerization ofhuman recombinant resisting involves covalent and nonco-valent interactions 显示文摘 | Raghu P Ghosh S Soundarya K | 2004 | Biochem Biophys Res Commun2004，313，3： | 1 |
| 19 | Effect of cinnamon and its procyanidin-B2 enriched fraction on diabetic nephropathy in rats显示文摘 | Muthenna P Raghu G Kumar PA | 2014 | Chem Biol Interact2014，222，： | 1 |
| 20 | Comparison of ascorbic acid content of Emblica officinal is fruits determined by different analytical methods显示文摘 | RAGHU V KALPANA P K | 2007 | Journal of Food Composition and Analysis2007，20，： | 1 |
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