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| 1 | Environmental Suitability and Distribution of the Caucasian Rock Agama,Paralaudakia caucasia (Sauria:Agamidae) in Western and Central Asia显示文摘Predictive potential distribution modeling is crucial in outlining habitat usage and establishing conservation management priorities.In this paper we provide detailed data on the distribution of the Caucasian rock agama Paralaudakia caucasia,and use species distribution models(MAXENT) to evaluate environmental suitability and potential distribution at a broad spatial scale.Locality data on the distribution of P.caucasia have been gathered over nearly its entire range by various authors from f ield surveys.The distribution model of P.caucasia showed good performance(AUC=0.887),and predicted high suitability in regions mainly located in Tajikistan,north Pakistan,Afghanistan,southeast Turkmenistan,northeast Iran along the Elburz mountains,Transcaucasus(Azerbajan,Armenia,Georgia),northeastern Turkey and northward along the Caspian Sea coast in Daghestan,Russia.The identifi cation of suitable areas for this species will help to assess conservation status of the species,and to set up management programs. | Seyyed Saeed HOSSEINIAN YOUSEFKHANI Gentile Francesco FICETOLA Nasrullah RASTEGAR-POUYANI Natalia B ANANJEVA Eskandar RASTEGAR-POUYANI Rafaqat MASROOR | 2013 | Asian Herpetological Research2013，4，3： | 4 |
| 2 | A zinc finger protein, interacted with cyclophilin,affects root development via IAA pathway in rice显示文摘The plant hormone auxin plays a crucial role in lateral root development. To better understand the molecular mechanisms underlying lateral root formation,an auxin-responsive gene OsCYP2(Os02g0121300) was characterized from rice. Compared to the wild type,OsCYP2-RNAi(RNA interference) lines exhibited distinctive defects in lateral root development. Yeast two-hybrid and glutathione S-transferase pull-down results confirmed that OsCYP2 interacted with a C2HC-type zinc finger protein(OsZFP, Os01g0252900) which is located in the rice nucleus. T_2 OsZFP-RNAi lines had significantly fewer lateral roots than did wild-type plants, which suggests a role for OsCYP2 and OsZFP in regulating lateral root development.Quantitative real-time polymerase chain reaction showed that the expression of certain Aux/IAA(auxin/indole-3-acetic acid) genes was altered in OsCYP2-and Os ZFP-RNAi lines in response to IAA. These findings imply that OsCYP2 and OsZFP participate in IAA signal pathways controlling lateral root development. More importantly, OsIAA11 showed functional redundancy not only in OsCYP2-RNAi lines but also in Os ZFP-RNAi lines, which provides important clues for the elucidation of mechanisms controlling lateral root development in response to auxin. | Peng Cui Hongbo Liu Songlin Ruan Basharat Ali Rafaqat Ali Gill Huasheng Ma Zhifu Zheng Weijun Zhou | 2017 | Journal of Integrative Plant Biology2017，59，7： | 4 |
| 3 | Distribution and Environmental Suitability of the Smallscaled Rock Agama, Paralaudakia microlepis(Sauria: Agamidae) in the Iranian Plateau显示文摘Predictive potential distribution modeling is of increasing importance in modern herpetological studies and determination of environmental and conservation priorities. In this article we provided results of analysis and forecasts of the potential distribution of smallscaled rock agama Paralaudakia microlepis(Blanford, 1874) using the distribution models through Maxent(www.cs.princeton.edu/ ~ schapire / maxent). We made an attempt for comparison of input of bioclimatic factors and characteristics of biotope distribution for three species of genus Paralaudakia. Constructed model identified dissemination of Paralaudakia microlepis enough performance(AUC = 0.972 with dispersion 0.003). According to the map constructed, the most suitable habitats of smallscaled rock agama Paralaudakia microlepis are located in southern and eastern Iran, the west of central Pakistan and southeastern Afghanistan. | Natalia B.ANANJEVA Evgeny A.GOLYNSKY Seyyed Saeed HOSSEINIAN YOUSEFKHANI Rafaqat MASROOR | 2014 | Asian Herpetological Research2014，5，3： | 3 |
| 4 | 除草剂丙酯草醚对大麦的影响和支链氨基酸对其生长的恢复作用(英文)显示文摘目的:评价除草剂丙酯草醚对大麦生长的影响,探讨外源添加支链氨基酸对其生长的恢复作用。创新点:从除草剂丙酯草醚作用机理出发,阐明了外源添加支链氨基酸对丙酯草醚作用下大麦各项生理和生长指标的缓解作用,为生长调节物质的进一步开发利用提供实验依据。方法:采用水培和大田实验相结合的方法,研究了除草剂丙酯草醚对大麦生长的影响,并通过进一步测定大麦幼苗各项生理指标和支链氨基酸浓度,表明100mg/L支链氨基酸可显著缓解丙酯草醚对大麦的生理损伤,从而恢复其生长。结论:外源添加支链氨基酸能够缓解除草剂丙酯草醚对大麦生长的抑制作用。 | Ling XU Jian-yao SHOU Rafaqat Ali GILL Xiang GUO Ullah NAJEEB Wei-jun ZHOU | 2019 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2019，20，1： | 2 |
| 5 | Chromium-induced physiochemical and ultrastructural changes in four cultivars of Brassica napus L显示文摘 | Rafaqat A G Lili Z Basharat A | 2015 | Chemosphere2015，120，2： | 1 |
| 6 | Tailoring of structural,electrical and magnetic properties of BaCo2W-type hexaferrites by doping with Zr-Mn binary mixtures for useful applications显示文摘 | Muhammad J I Rafaqat A K Shigemi M | | 0，，16： | 1 |
| 7 | Estimation of Genetic Divergence and Character Association Studies in Local and Exotic Diversity Panels of Soybean(Glycine max L.)Genotypes显示文摘The availability of favorable genetic diversity is a thriving vitality for the success of a breeding program.It provides a firm basis of selecting superior breeding lines for the development of high yielding crop genotypes.In this context,present investigation aimed to generate information on genetic divergence and character association in a diversity panel of 123 local and exotic soybean genotypes.Analysis of variance revealed significant response of the evaluated genotypes based on studied attributes.It depicted the probability of selecting desirable soybean genotypes by focusing on character association studies and genetic diversity analysis.Correlation analysis revealed that seed yield per plant showed high positive correlation with 100-seed weight followed by pods per plant and plant height.Furthermore,path coefficient analysis exposed that pods per plant had maximum direct contribution in seed yield per plant followed by 100-seed weight,days to flowering and SPAD measurement.Genotype named“G-10”showed maximum yield per plant followed by 24607,G-52,24593,Arisoy,24566,17426,A-3127,24570 and 24567.Genetic diversity analysis grouped the evaluated germplasm into 17 clusters.All clusters showed zero intra-cluster variability;while inter-cluster divergence ranged from 9.00 to 91.11.Cluster V showed maximum inter-cluster distance with cluster XII followed by that of between V and VIII.Moreover,cluster IV with superior genotypes(G-10,24607,24593 and 24566),VI(17426 and 24567),XIII(24570)and X(Arisoy and G-52)showed above mean values for most of the studied characters.Overall,the results of hybridization between the superior genotypes of these cluster pairs might be useful for soybean breeding with improving agronomic traits and adaptability. | Syed Ali Zafar Muhammad Aslam Haroon Zaman Khan Sehrish Sarwar Rao Saad Rehman Mariam Hassan Ramala Masood Ahmad Rafaqat AGill Basharat Ali Ibrahim Al-Ashkar Abdullah Ibrahim Md Atikur Rahman Ayman El Sabagh | 2023 | Phyton-International Journal of Experimental Botany2023，92，6： | 0 |
| 8 | Computational Tools and Resources for CRISPR/Cas Genome Editing显示文摘The past decade has witnessed a rapid evolution in identifying more versatile clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein(Cas)nucleases and their functional variants,as well as in developing precise CRISPR/Cas-derived genome editors.The programmable and robust features of the genome editors provide an effective RNAguided platform for fundamental life science research and subsequent applications in diverse scenarios,including biomedical innovation and targeted crop improvement.One of the most essential principles is to guide alterations in genomic sequences or genes in the intended manner without undesired off-target impacts,which strongly depends on the efficiency and specificity of single guide RNA(sgRNA)-directed recognition of targeted DNA sequences.Recent advances in empirical scoring algorithms and machine learning models have facilitated sgRNA design and off-target prediction.In this review,we first briefly introduce the different features of CRISPR/Cas tools that should be taken into consideration to achieve specific purposes.Secondly,we focus on the computer-assisted tools and resources that are widely used in designing sgRNAs and analyzing CRISPR/Cas-induced on-and off-target mutations.Thirdly,we provide insights into the limitations of available computational tools that would help researchers of this field for further optimization.Lastly,we suggest a simple but effective workflow for choosing and applying web-based resources and tools for CRISPR/Cas genome editing. | Chao Li Wen Chu Rafaqat Ali Gill Shifei Sang Yuqin Shi Xuezhi Hu Yuting Yang Qamar U.Zaman Baohong Zhang | 2023 | Genomics, Proteomics & Bioinformatics2023，21，1： | 0 |
| 9 | Hydrothermal synthesis and characterization of carbon-doped TiO2 nanoparticles显示文摘We report the hydrothermal growth of pure and doped TiO2 nanoparticles with different concentrations of carbon.The microstructure of the as-synthesized samples is characterized by x-ray diffraction(XRD),field emission scanning electron microscopy(FESEM),energy dispersive x-ray spectroscopy(EDX),and Raman spectroscopy to understand the structure and composition.The XRD patterns confirm the formation of anatase phase of TiO2 with the average crystallite size is calculated to be in the range of 13 nm to 14.7 nm.The functional groups of these nanostructures are characterized by Fourier transformed infrared(FT-IR)spectroscopy,which further confirms the single anatase phase of the synthesized nanostructures.UV-visible absorption spectroscopy is used to understand the absorption behavior,which shows modification in the optical bandgap from 3.13 eV(pure TiO2)to 3.74 eV(1.2 mol%C-doped TiO2).Furthermore,the Ti^3+centers associated with oxygen vacancies are identified using electron paramagnetic resonance spectroscopy(EPR). | Zafar Ali Javaid Ismail Rafaqat Hussain AShah Arshad Mahmood Arbab Mohammad Toufiq Shams ur Rahman | 2020 | Chinese Physics B2020，29，11： | 0 |
| 10 | Role of major adipokines in hypertension:A literature review显示文摘The incidence and prevalence of hypertension are increasing as a consequence of the obesity epidemic.Adipocytes and their variety of factors make contributions to the long-term regulation of blood pressure.The pathophysiologic states of hypertension,including obesity,are regulated by the production of adipocytederived factors.Increased body mass index was closely linked to elevated blood pressure.Mostly the hypertensive subjects were obese as well as overweight.There are numerous adipokines,however,this review article only focuses on the major adipokines including chemerin,visfatin,retinol-binding protein 4,plasminogen activator inhibitor-1,monocyte chemotactic protein-1,omentin-1,lipocalin-2,vaspin,progranulin,complement c1q tumor necrosis factor-related protein,and nesfatin-1 role in the pathogenesis of hypertension.This review article concludes the significant association of major adipokines in the pathogenesis of hypertensives.New research should be focused on other newly reported adipokine roles in hypertensive subjects and the management of these adipokines in hypertensive subjects.The discovery of this information could result in the creation of antihypertensive medications,particularly those that focus on obesity-related hypertension. | Saira Rafaqat Sobia Nasreen Sana Rafaqat | 2023 | World Journal of Hypertension2023，11，1： | 0 |
| 11 | Role of IL-2/IL-2 receptor in pathogenesis of autoimmune disorders:Genetic and therapeutic aspects显示文摘Interleukin-2(IL-2)is an important cytokine that plays a key role in the immune response.The IL-2 receptor(IL-2R)is composed of three subunits,alpha,beta,and gamma,with the alpha subunit having the highest affinity for IL-2.Several studies reported that immune dysregulation of IL-2 may cause tissue injury as well as damage leading to the pathogenesis of various autoimmune diseases such as acute necrotizing vasculitis in systemic lupus erythematosus(SLE),inflammatory synovitis in rheumatoid arthritis(RA),salivary and lacrimal gland dysfunction in Sjogren syndrome(SS),obliterative vasculopathy fibrosis in systemic sclerosis(SSc),and inflammatory demyelination in multiple sclerosis(MS).The aim of this review paper was to examine the role of IL-2/IL-2R in various autoimmune disorders,taking into account recent advancements and discoveries,gaps in the current literature,ongoing debates,and potential avenues for future research.The focus of this review is on systemic lupus erythematosus,rheumatoid arthritis,systemic sclerosis,sjogren syndrome,and multiple sclerosis,which are all linked to the malfunctioning of IL-2/IL-2R.In genetic studies,gene polymorphisms of IL-2 such as IL-2330/T,IL-2330/G,and rs2069763 are involved in increasing the risk of SLE.Furthermore,genetic associations of IL-2/IL-2R such as rs791588,rs2281089,rs2104286,rs11594656,and rs35285258 are significantly associated with RA susceptibility.The IL-2 polymorphism including rs2069762A,rs6822844T,rs6835457G,and rs907715T are significant connections with systemic sclerosis.In addition,rs2104286(IL-2),rs11594656(IL-2RA),rs35285258(IL-2RB)gene polymorphism significant increases the risk of multiple sclerosis.In therapeutic approaches,low-dose IL-2 therapy could regulate Tfr and Tfh cells,resulting in a reduction in disease activity in the SLE patients.In addition,elevated sIL-2R levels in the peripheral blood of SLE patients could be linked to an immunoregulatory imbalance,which may contribute to the onset and progression of SLE.Consequently,sIL-2R could potentially be a target for future SLE therapy.Moreover,Low dose-IL2 was well-tolerated,and low levels of Treg and high levels of IL-21 wereassociated with positive responses to Ld-IL2 suggested to be a safe and effective treatment for RA.Additionally,low-dose IL-2 treatment improves the exocrine glands'ability to secrete saliva in SS-affected mice.Whereas,Basiliximab targets the alpha chain of the IL-2 receptor suggested as a potential treatment for SSc.Also,pre-andpost-treatment with Tregs,MDSCs,and IL-2 may have the potential to prevent EAE induction in patients with MS.It is suggested that further studies should be conducted on IL-2 polymorphism in Sjogren syndrome. | Sana Rafaqat Saira Rafaqat | 2023 | World Journal of Medical Genetics2023，11，3： | 0 |
| 12 | Overview of microbes in hypertension显示文摘High blood pressure(BP),known as hypertension,is a major contributing factor to the development of cardiovascular disease.The development and pathogenesis of hypertension involve a wide array of factors including genetics,environment,hormones,hemodynamics,and inflammation.There is a significantly positive association between higher levels of colonization by Aggregatibacter actinomycetemcomitans,Porphyromonas gingivalis,Tannerella forsythia,and Treponema denticola(etiologic bacterial burden)below the gum line,and the presence of hypertension.The use of antibiotics during pregnancy,which is likely indicative of bacterial infections severe enough to require antibiotic treatment,is associated with a slight increase in average arterial BP.Cytomegalovirus infection is a risk factor for heightened arterial BP and acts as a co-factor in the development of aortic atherosclerosis.The relationship between hypertension and coronavirus disease 2019 involves endothelial dysfunction and dysregulation of the renin-angiotensin system.The effects of gut microbiota on BP,whether beneficial or harmful,are influenced by multiple factors including genetics,epigenetics,lifestyle choices,and antibiotic usage.These variables collectively contribute to overall BP levels and the control of hypertension.Several reports have examined the BP levels of patients infected with the Zika virus.In regions with a high incidence of nasopharyngeal carcinoma,hypertension has been linked to a higher risk of Epstein-Barr virus reactivation.Also,a potential causal link has been found between malaria and elevated BP.Also,the elevated prevalence of hypertension among dengue patients during their initial visit suggests that relying solely on BP measurements to predict severe infection may not be clinically reliable. | Huma Khurshid Saira Rafaqat Sana Rafaqat | 2023 | World Journal of Hypertension2023，11，2： | 0 |
| 13 | Matter accretion onto Einstein-aether black holes via well-known fluids显示文摘We study matter accretion onto Einstein-aether black holes by adopting the Hamiltonian approach.The general solution of accretion is discussed using the isothermal equation of state.Different types of fluids are considered,including ultra-relativistic,ultra-stiff,sub-relativistic,and radiation fluids,and the accretion process onto Einstein-aether black holes is analyzed.The behavior of the fluid flow and the existence of critical points is investigated for Einstein-aether black holes.We further discuss the general expression and behavior of polytropic fluid onto Einstein-aether black holes.The most important feature of this work is the investigation of the mass accretion rate of the above-mentioned fluids and the comparison of our findings with the Schwarzschild black hole,which generates particular signatures.Moreover,the maximum mass accretion rate occurs near the Killing and universal horizons,and the minimum accretion rate lies between them. | M.Umair Shahzad Rafaqat Ali Abdul Jawad Shamaila Rani | 2020 | Chinese Physics C2020，44，6： | 0 |
| 14 | Cardiac markers: Role in the pathogenesis of arterial hypertension显示文摘Cardiac biomarkers may play unique roles in the prognostic evaluation of patients with hypertension,as many cardiac biomarker levels become abnormal long before the onset of obvious cardiovascular disease(CVD).There are numerous cardiac markers.However,this review article only reported the roles of creatinine kinase-MB,cardiac troponins,lipoprotein a,osteopontin,cardiac extracellular matrix,C-reactive protein,cardiac matrix metalloproteinases,cardiac natriuretic peptides,myoglobin,renin,and dynorphin in the pathogenesis of hypertension.This article explained recent major advances,as well as discoveries,significant gaps,and current debates and outlined possible directions for future research.Further studies are required to determine the association between myoglobin and other cardiac markers in hypertension.Moreover,therapeutic approaches are required to determine the early control of these cardiac markers,which ultimately reduce the prevalence of CVDs. | Saira Rafaqat Shaheed Afzal Sana Rafaqat Huma Khurshid Simon Rafaqat | 2022 | World Journal of Hypertension2022，10，1： | 0 |
| 15 | Microwave-assisted pre-ionization experiments on GLAST-Ⅲ显示文摘GLAss Spherical Tokamak(GLAST-Ⅲ)is a spherical tokamak with an insulating vacuum vessel that has a unique single-passage capability for incident microwaves.In this work,electron cyclotron resonance heating(ECRH)-assisted plasma pre-ionization in GLAST-Ⅲis explored for three radio-frequency(RF)polarizations(the O-,X-,and M-modes)at different toroidal-field(TF)strengths and filled gas pressures.The optimum hydrogen pressure is identified for efficient plasma pre-ionization.A comparison of the plasma pre-ionizations initiated by the O-,X-,and M-modes shows prominent differences in the breakdown time,location,and wave absorption.In the case of O-mode polarization,microwave absorption occurs for a relatively shorter duration,resulting in a bell-shaped electron-temperature(Te)temporal profile.Microwave absorption is dominant in the case of the X-mode,leading to a broader Te temporal profile.The M-mode discharge contains features of both the X-and O-modes.Efficient plasma pre-ionization is achieved in the X-mode polarization for the intermediate TF strengths(with a central toroidal magnetic field B0=0.075 T).Traces of the electron-number density show a similar tendency,as revealed by Te.These results suggest that the X-mode is the best candidate for efficient plasma pre-ionization at low filled gas pressures(10-2 Pa)in small tokamaks. | Riaz KHAN Sehrish SHAKIR Ahmad ALI Muhammad Khawar AYUB Moazzam NAZIR Zia UR-REHMAN Abdul QAYYUM Muhammad Athar NAVEED Sarfraz AHMAD Zahoor AHMAD Rafaqat ALI Shahid HUSSAIN | 2021 | Plasma Science and Technology2021，23，8： | 0 |
| 16 | Pancreatic biomarkers:role in diabetes mellitus显示文摘Diabetes mellitus refers to a group of diseases that cause high blood sugar levels.The most common type is type 2 diabetes,which is caused by insulin resistance and inadequate insulin production.However,diabetes can also result from conditions affecting the exocrine pancreas.Both type 1 and type 2 diabetes patients may experience changes in their pancreatic exocrine function,leading to reduced levels of fecal elastase-1 in many cases.This review article focuses on the role of specific pancreatic biomarkers in diabetes mellitus,including cholecystokinin,trypsin,chymotrypsin,carboxypeptidase,amylase,lipase,secretin,elastase-1,and retinol-binding protein 4 about recent advances and discoveries,significant gaps in the literature,current debates,and potential directions for future research related to these biomarkers about diabetes mellitus.This review article discusses various biomarkers related to pancreatic exocrine and endocrine function and their implications in diabetes.It suggests that gut cholecystokinin may play a role in lowering glucose synthesis through a neural network and resistance to it could contribute to hyperglycemia in diabetic patients.It also discusses the use of various markers such as serum trypsin concentration,amylase and lipase levels,pancreatic elastase levels,and fasting secretin levels to assess pancreatic exocrine function.Additionally,the article explores the role of carboxypeptidase E in the endocrine and neurological systems and its association with disorders.Moreover,it also highlights the involvement of retinol-binding protein 4 in the development of type 2 diabetes and insulin resistance. | Sana Rafaqat Ramsha Hafeez Rida Mairaj Abeerah Saleem Saira Rafaqat | 2023 | Journal of Pancreatology2023，6，4： | 0 |
| 17 | Role of hematological parameters in pathogenesis of diabetes mellitus:A review of the literature显示文摘Diabetes mellitus(DM)is characterized by hyperglycemia and abnormalities in insulin secretion and activity.There are numerous hematological parameters;however,this review article only focuses on red blood cells,hemoglobin,hematocrit,red blood cell indices,platelet count,white blood cells,lymphocytes,neutrophils,monocytes,eosinophils,neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio,and monocyte-to-lymphocyte ratio,which play an essential role in the pathogenesis of DM.Also,this review article aims to report the relationship between these hematological parameters and the development of DM.In con-clusion,this article shows that increased levels of platelets,red blood cells,hematocrit,lymphocytes,eosinophils,neutrophils,neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio,and monocyte-to-lymphocyte ratio and decreased levels of hemoglobin are involved in the pathogenesis of DM.However,the role of basophils in DM is unknown yet. | Sana Rafaqat Saira Rafaqat | 2023 | World Journal of Hematology2023，10，3： | 0 |
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