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| 1 | The modulation of co-stimulatory molecules by circulating exosomes in primary biliary cirrhosis显示文摘Exosomes 是 endocytic 起源的 nanoparticles,由由他们调制 cell-to-cell 通讯的能力的优点正在吸引增加的注意的无数房间人口藏匿了。他们也在许多免疫学的问题正在吸引注意,包括 autoimmunity 和,特别地调整 cytokine 和 chemokine 激活的他们的能力。主要胆汁的肝硬化(PBC ) 被认为一个模型自体免疫疾病,它对胆汁的上皮的房间有高度集中的细胞毒素的回答。我们与 PBC 和 30 健康控制(HC ) 从 29 个病人从血浆孤立 exosomes,并且用一个前 vivo 系统在 mononuclear 房间人口在 co-stimulatory 分子表示和 cytokine 生产上学习了这些 exosomes 的效果。我们也与 HC exosomes 相比在 PBC 识别了 microRNA (miRNA ) 人口。我们此处报导尽管 exosomes 不改变 cytokine 生产,他们显著地确实在介绍抗原的人口上改变 co-stimulatory 分子表示。进一步,我们在 CD14 + 单核白血球上表明了那 CD86 起来调整的表情,而在 CD11c + 上起来调整的 CD40 由从有 PBC 的病人的 exosomes 的树枝状的房间。另外,有在有 PBC 的病人的传播 exosomes 的 miRNA 表示的差别。这些数据基于 co-stimulatory 分子玩的观察有重要重要性在 T 房间激活的规定的一个微分角色。我们的观察显示从 PBC 的异常 exosomes 有选择地在介绍抗原的房间的不同子集导致 co-stimulatory 分子的表示。这些改变可以在自体免疫的肝疾病的致病包含。 | Takashi Tomiyama Guo-Xiang Yang Ming Zhao Weici Zhang Hajime Tanaka Jing Wang Patrick SC Leung Kazuiclli Okazaki Xiao-Song He Qianjin Lu Ross L Coppel Christopher L Bowlus M Eric Gershwin | 2017 | Cellular & Molecular Immunology2017，14，3： | 18 |
| 2 | Beyond the Pediatric end-stage liver disease system: Solutions for infants with biliary atresia requiring liver transplant显示文摘Biliary atresia(BA), a chronic progressive cholestatic disease of infants, is the leading cause for liver transplant in children, especially in patients under two years of age. BA can be successfully treated with the Kasai portoenterostomy; however most patients still require a liver transplant, with up to one half of BA children needing a transplant by age two. In the current pediatric end-stage liver disease system, children with BA face the risk of not receiving a liver in a safe and timely manner. In this review, we discuss a number of possible solutions to help these children. We focus on two general approaches:(1) preventing/delaying need for transplantation, by optimizing the success of the Kasai operation; and(2) expediting transplantation when needed, by performing techniques other than the standard deceased-donor, whole, ABO-matched organ transplant. | Mary Elizabeth M Tessier Sanjiv Harpavat Ross W Shepherd Girish S Hiremath Mary L Brandt Amy Fisher John A Goss | 2014 | World Journal of Gastroenterology2014，20，32： | 14 |
| 3 | Diet and fecal lipids following cholecystectomy in men显示文摘 | BRYDON W G ROSS M C L ANDERSON J R | 1982 | Digestion1982，25，： | 1 |
| 4 | Behavioural and physiological characteristicsof the Antarctic krill, Euphausia superba 显示文摘 | Quetin L Ross R M | 1991 | American Zoologist1991，31，1： | 1 |
| 5 | Average magnitude difference function pitch extractor显示文摘 | ROSS M J SHAFFER H L COHEN A | 1974 | IEEE Trans on Acoustics Speech and Signal Processing1974，22，5： | 1 |
| 6 | Numerical simulation of high strain rate concrete compress test 显示文摘 | Tedesco J W Hughes M L Ross C A | 1994 | Computers & Struc- tures1994，51，1： | 1 |
| 7 | Neurological evaluation of toxic axonopathies in rats: acrylamide and 2,5-hexanedione显示文摘 | LOPACHIN R M ROSS J F REID M L | 2002 | Neurotoxicology2002，23，1： | 1 |
| 8 | Neurodegenerative actions of interleukin-1 in the rat brain are mediated through increases in seizure activity显示文摘 | Patel H C Ross F M Heenan L E | 2006 | Journal of Neuroscience Research2006，83，3： | 1 |
| 9 | Numerical simu-lation of high strain rate concrete compression tests显示文摘 | Tedesco J W Hughes M L Ross C A | 1994 | Computers & Structures1994，51，1： | 1 |
| 10 | Selective ex- pression in carotid body lype l ceils of a single sphce variant of the large conductance calcium- and voltage-activated pates-sium channel confers regulation by AMP-activaled protein ki- nase显示文摘 | ROSS F A RAFFEBTY J N DALLAS M L et el | 2011 | J Biol Chem2011，286，11： | 1 |
| 11 | Occupation of biological space during seedling establishment显示文摘 | Ross M A Harper J L | 1972 | Journal of Ecology1972，60，： | 1 |
| 12 | Numerical analysis of high strain rate spiltting-tensile tests显示文摘 | Hughes M L Tedesco Ross A | 1993 | Computers and Structures1993，47，： | 1 |
| 13 | Growth limitation inyoung Euphausia superba under field conditions 显示文摘 | Ross R M Quetin L B Baker K S | 2000 | Limnologyand Oceanography2000，45，1： | 1 |
| 14 | A Strain-rate-dependent concrete material model for ADINA显示文摘 | Tedesco J W Powell J C Ross C Hughes M L | 1997 | Computers & Structures1997，64，56： | 1 |
| 15 | Lifestyle Physical Activity Interventions: History, Short- and Long-term Effects, and Recommendations显示文摘 | Andrea L D Ross E A John M J | 1998 | American Journal of Preventive Medicine1998，15，4： | 1 |
| 16 | Effectiveness of a training program to increase the capacity of heahh care providers to provide HIV care and treatment in Swaziland 显示文摘 | Kamiru H N Ross M W Bartholomew L K | 2009 | AIDS Care2009，21，11： | 1 |
| 17 | Adult exposure influences offspring response to ocean acidification in oysters显示文摘 | Parker L M Ross P M O'Connor W A | 2012 | Global Change Biology2012，18，1： | 1 |
| 18 | Early microbial translocation blockade reduces SIV-mediated inflammation and viral replication显示文摘 | Kristoff Jan Haret-Richter George Ma Dongzhu Ribeiro Ruy M Xu Cuiling Cornell Elaine Stock Jennifer L He Tianyu Mobley Adam D Ross Samantha Trichel Anita Wilson Cara Tracy Russell Landay Alan Apetrei Cristian Pandrea Ivona | 2014 | Journal of Clinical Investigation2014，，： | 1 |
| 19 | The dependence of transistor parameters on the distribution of base layer resistivity 显示文摘 | Moll J L Ross I M | 1956 | Proceedings of IRE1956，44，1： | 1 |
| 20 | DNA surveillance: web-based molecular identification of whales, dolphins, and porpoises显示文摘 | Ross H A Lento G M Dalebout M L | 2003 | J Hered2003，94，2： | 1 |
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